1. Disease and treatment-related comorbidities in rheumatoid arthritis
- Author
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Özlem Doğan Ağbuga and Emine Duygu Ersözlü
- Subjects
rheumatoid arthritis ,comorbidity ,treatment ,Medicine - Abstract
Rheumatoid arthritis (RA) is a chronic, progressive disease affecting systemic connective tissues, including synovial membranes in joints and extra-articular systems. The global prevalence is estimated between 0.5% and 2%, with a higher incidence observed in women, individuals with a family history, and smokers. The disease’s etiology is primarily attributed to immune processes in the synovial membrane and fluid of joints. Importantly, RA is a systemic condition affecting joints, organs, and systems, including the cardiovascular, renal, pulmonary, and neuropsychiatric systems. In one study, 40% of RA patients experienced complications, with a significant incidence of 8.3% among those with cardiovascular disease, interstitial lung disease, osteoporosis, and metabolic syndrome. Sustained inflammation and immune dysregulation, hallmark features of RA, significantly contribute to the onset and progression of associated comorbidities. Comorbidities frequently coexisting with RA encompass cardiovascular diseases, pulmonary disorders, osteoporosis, malignancies, and infections. Such comorbidities exert a direct impact on patient quality of life, functional capacity, and mortality rates. The emergence of these comorbid conditions is not solely attributable to the disease itself but may also be influenced, either positively or negatively, by the therapeutic agents employed.
- Published
- 2024
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