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Dyslexia is a complex reading disorder characterized by difficulties in accurate or fluent word recognition, poor spelling, and decoding abilities. These challenges are not due to intellectual, visual, or auditory deficits. The diagnosis of dyslexia is further complicated by symptom variability, influenced by cultural and personal factors. This study leverages Virtual Reality (VR) advancements, eye movement tracking, and machine learning to create a virtual reading environment that captures eye movement data. This data extracts features such as eye movement metrics, word vectors, and saliency maps. We introduce a novel fusion model that integrates various machine learning algorithms to objectively and automatically assess dyslexia using physiological data derived from user interactions. Our findings suggest that this model significantly enhances the accuracy and efficiency of dyslexia diagnosis, marking an important advancement in educational technology and providing robust support for individuals with dyslexia. Although the sample size was limited to 10 dyslexic and 4 control participants, the results offer valuable insights and lay the groundwork for future studies with larger cohorts.

Objective: Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a prevalence ranging from 6.1 to 9.4%. The main symptoms of ADHD are inattention, hyperactivity, impulsivity, and even destructive behaviors that may have a long-term negative influence on learning performance or social relationships. Early diagnosis and treatment provide the best chance of reducing and managing symptoms. Currently, ADHD diagnosis relies on behavioral observations and ratings by clinicians and parents. Medical diagnosis of ADHD was reported to be delayed because of a global shortage of well-trained clinicians, the heterogeneous nature of ADHD, and combined comorbidities. Therefore, alternative ways to increase the efficiency of early diagnosis are needed. Previous studies used behavioral and neurophysiological data to assess patients with ADHD, yielding an accuracy range from 56.6% to 92%. Several factors were shown to affect the detection rate, including methods and tasks used and the number of electroencephalogram (EEG) channels. Given that children with ADHD have difficulty sustaining attention, in this study, we tested whether data from multiple tasks with different difficulties and prolonged experiment times can probe the levels of brain resources engaged during task performance and increase ADHD detection. Specifically, we proposed a Deep Neural Network-based (DNN) fusion model of multiple tasks to enhance the detection of ADHD. Methods & Results: Forty-nine children with ADHD and thirty-two typically developing children were recruited. Analytic results show that the fusion of multi-task neurophysiological data can increase the separation rate to 89%, whereas a single data type can only achieve a best accuracy of 81%. Moreover, the use of multiple tasks helps distinguish between children with ADHD and typically developing children. Our results suggest that different neurophysiological models from multiple tasks can provide essential information to assist in ADHD screening. In conclusion, the proposed model offers a more efficient, and accurate alternative for early clinical diagnosis and management of ADHD. The application of artificial intelligence and multimodal neurophysiological data in clinical settings sets a precedent for digital health, paving the way for future advancements in the field.

Advanced Persistent Threat (APT) groups pose significant cybersecurity threats due to their sophisticated and persistent nature. This study introduces a novel methodology to understand their collaborative patterns and shared objectives, which is crucial for developing robust defense mechanisms. We utilize MITRE ATT&CK Techniques, software, target nations, and industries as our primary features to understand the characteristics of APT groups. Since essential information is often buried within the unstructured data of Cyber Threat Intelligence (CTI) reports, we employ Natural Language Processing (NLP) and Named Entity Recognition (NER) to extract relevant data. To analyze and interpret the complex relationships between APT groups, we compute similarity among the features using weighted cosine similarity metrics and Machine Learning (ML) models, enhanced by feature crosses and feature selection strategies. Subsequently, hierarchical clustering is used to group APTs based on their similarity scores, helping to identify common behaviors and uncover deeper relationships. Our methodology demonstrates notable clustering performance, with a silhouette coefficient of 0.76, indicating strong intra-cluster similarity. The Adjusted Rand Index (ARI) of 0.63, though moderate, effectively measures agreement between our clustering and the ground truth. These metrics provide robust validation, surpassing commonly recognized benchmarks for effective clustering in cybersecurity. Our methodology successfully classifies 23 distinct APT groups into six clusters, highlighting the importance of techniques and industry features in the clustering process. Notably, techniques such as T1059 (Command and Scripting Interpreter) and T1036 (Masquerading) are prevalently deployed, observed in 18 out of 23 APT groups across all six clusters.

Methamphetamine use disorder (MUD) is an illness associated with severe health consequences. Virtual reality (VR) is used to induce the drug-cue reactivity and significant EEG and ECG abnormalities were found in MUD patients. However, whether a link exists between EEG and ECG abnormalities in patients with MUD during exposure to drug cues remains unknown. This is important from the therapeutic viewpoint because different treatment strategies may be applied when EEG abnormalities and ECG irregularities are complications of MUD. We designed a VR system with drug cues and EEG and ECG were recorded during VR exposure. Sixteen patients with MUD and sixteen healthy subjects were recruited. Statistical tests and Pearson correlation were employed to analyze the EEG and ECG. The results showed that, during VR induction, the patients with MUD but not healthy controls showed significant $\alpha $ and $\beta $ power increases when the stimulus materials were most intense. This finding indicated that the stimuli are indiscriminate to healthy controls but meaningful to patients with MUD. Five heart rate variability (HRV) indexes significantly differed between patients and controls, suggesting abnormalities in the reaction of patient’s autonomic nervous system. Importantly, significant relations between EEG and HRV indexes changes were only identified in the controls, but not in MUD patients, signifying a disruption of brain-heart relations in patients. Our findings of stimulus-specific EEG changes and the impaired brain-heart relations in patients with MUD shed light on the understanding of drug-cue reactivity and may be used to design diagnostic and/or therapeutic strategies for MUD.

Possible symptoms of intellectual disability (ID) include delayed physical development that becomes more pronounced as the disability progresses, delayed development of gross and fine motor skills, sensory perception problems, and difficulty grasping the integrity of objects. Although there is no cure or reversal, research has shown that extensive training and learning can lead to easier social integration, but the human demands of diagnosis and the cost of training often result in overburdened families of origin, an unmanageable workload for teachers, and high social costs. Therefore, it is important to conduct efficient, effective, and economical assessments in a safe and reproducible training environment. Currently, the assessment of ID relies on intelligence tests, such as the Wechsler intelligence scale and the vineland adaptive behavior scale. With the rapid development of virtual reality (VR) and machine learning (ML), we created a virtual supermarket and then collected data in three areas, including eye movements, brain waves, and behaviors. We also propose an intelligent executive function evaluation using ML to develop a more objective and automatic evaluation model based on real data through physiological data obtained from user reflections. Statistical analysis of the obtained data showed that some data metrics derived from behavioral information differed significantly between ID patients and healthy participants. This shows that it is possible to perform classification through neural networks, even at multiple levels, which may prove effective for vocational training through VR.