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Background: The integration of interdisciplinary clinical reasoning and decision-making into the medical curriculum is imperative. Novel, high-quality e-learning environments, encompassing virtual clinical and hands-on training, are essential. Consequently, we evaluated the efficacy of a case-based e-learning approach., Method: The impact of a case-based interdisciplinary e-learning environment with an integrated question/feedback system on medical students' academic performance was examined in a cross-sectional sample of different study years, longitudinally matched per academic year. Differences between the groups were analyzed through an unpaired t -test., Results: The exam results of students who participated in the e-learning course ( n = 296) were compared with those of all students at the university ( n = 5,800). A statistically significant ( p -value < 0.01) improvement in students' final examination grades was observed through intensive training on the offered platform., Conclusions: Our analyses demonstrated the positive influence of a case-based e-learning approach within the Viennese medical curriculum., Competing Interests: The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025 Ertl, Wadowski and Löffler-Stastka.)