7 results on '"Erythroid Hyperplasia"'
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2. Pediatric Myeloid Neoplasms With UBTFTandem Duplications
- Author
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Khanlari, Mahsa, Wang, Wei, Ni, Yonghui, Mead, Paul E., Umeda, Masayuki, Westover, Tami, Ma, Jing, Rubnitz, Jeffrey E., Barajas, Juan M., Pounds, Stanley, and Klco, Jeffery M.
- Abstract
Tandem duplications (TDs) in exons of upstream binding transcription factor (UBTF-TD) are a rare recurrent alteration in pediatric and adult acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)/neoplasm. Although recently identified, AML with UBTF-TD is now considered a distinct subtype of AML. To further our understanding of myeloid neoplasms with UBTF-TD, we analyzed clinical, morphologic, and immunophenotypic characteristics of 27 pediatric patients with UBTF-TD-positive myeloid neoplasm, including 21 diagnosed as AML and 6 as MDS. Our data demonstrated that UBTF-TD is frequently associated with cytopenia, hypercellular marrow with erythroid hyperplasia, and trilineage dysplasia. Blasts and maturing myeloid cells show a characteristic dysplastic feature with condensed eosinophilic cytoplasm. Blasts have a myeloid or myelomonocytic immunophenotype with a variably dim expression of CD34 and/or CD117, and except for CD7 expression lack a consistent pattern of aberrant lineage-specific antigen expression. Patients with MDS had a lower blast count in the peripheral blood (P =0.03) and bone marrow (P<0.001) but otherwise had no significant differences in other hematological parameters. Three patients with MDS rapidly progressed to AML in 33, 39, and 210 days from the initial diagnosis and there was no difference in overall survival between patients with MDS and AML (P =0.18). Our data suggest that MDS with UBTF-TDis prognostically equivalent to AML with UBTF-TD and thus should be considered as a continuum of the same molecularly defined myeloid neoplasm. These collective data also provide morphologic and immunophenotypic clues that can prompt screening for UBTF-TD in patients with MDS or AML.
- Published
- 2025
- Full Text
- View/download PDF
3. Congenital Methemoglobinemia: A Cause of Polycythemia
- Author
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Rathod, Santosh Govind, Kabir, Saima, Geelani, Sajad Ahmed, Khan, Afaq Ahmad, Roshan, Reshma, and Bhat, Javid Rasool
- Published
- 2025
- Full Text
- View/download PDF
4. Research from King George's Medical University Yields New Study Findings on Autoimmune Hemolytic Anemia (Autoimmune hemolytic anemia as initial presentation of acute myeloid leukemia)
- Subjects
Hemolytic anemia -- Research -- Reports ,Health - Abstract
2025 JAN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on autoimmune hemolytic anemia is now available. According to news [...]
- Published
- 2025
5. Herbal Medicine for Rare Diseases : Alleviating Symptoms by GMP Herbal Formulations
- Author
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Sun-Chong Wang, Meng-hua Chen, Sun-Chong Wang, and Meng-hua Chen
- Abstract
Many rare diseases are genetic and lack effective cures. Herbal medicine, developed by ancient healers without the benefit of modern cell biology knowledge, focuses on alleviating symptoms associated with uncommon conditions. Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations adopts an herbal medicine approach to addressing signs and symptoms of rare diseases.Each herb possesses a multitude of compounds that allow it to treat various conditions, while a single condition can often be addressed by several different herbs, illustrating complex relationships that artificial intelligence (AI) excels at deciphering. The herbal prescriptions in this book are generated using AI models, trained on a decade's worth of medical insurance data from Taiwan, featuring the use of Good Manufacturing Practice (GMP)-certified traditional Chinese medicine (TCM) products. The connection between deep learning and big data ensures that the trained AI model represents the collective wisdom of ~5,000 herbal medical doctors in Taiwan who contributed to the training data.Features Prescribes granulated herbal products sourced from GMP-certified manufacturers to ensure quality and safety Provides precise dosage information for the GMP herbal products in every prescription Includes a wealth of common and alternative herbal prescriptions tailored for specific conditions or combinations thereof Cites evidence from preclinical and clinical studies of the herb and formula to offer insights into their efficacy and mechanisms In each section Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations, AI-generated prescriptions are meticulously annotated with evidence from modern pharmacological and phytochemical studies of the herbs and multi-herb formulas included in the prescriptions. This book is beneficial for health professionals and practitioners, particularly those who specialise in complementary, alternative, and herbal medicine.
- Published
- 2025
6. The Cat - E-Book : The Cat - E-Book
- Author
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Susan E. Little and Susan E. Little
- Subjects
- Cats--Nutrition, Cats--Behavior, Cats--Diseases--Diagnosis, Cats--Diseases--Treatment
- Abstract
Comprehensive in scope and exclusively devoted to feline medical care, Dr. Susan Little's The Cat: Clinical Medicine and Management, 2nd Edition, is an essential resource for providing complete, state-of-the-art care to cats. Authoritative, clinically focused information is enhanced by full-color images, tables, boxes, algorithms, key points, and more — all in an easy-to-understand, quick-reference format. Dr. Little and her expert contributors address the unique concerns and challenges facing any practitioner providing care for cats, including the latest advances in feline medical diagnosis and management and the clinical applications to everyday practice. An eBook version, included with print purchase, provides access to all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook also offers convenient video lessons and client handouts. - Covers the latest advances in feline medicine from a systemic and adjunctive care perspective, making it the most comprehensive feline medical reference available with a strong clinical focus. - Addresses key topics unique to feline medicine and not currently covered in other books, including: insights and clinical advances attributable to the mapping of the feline genome; medical conditions associated with behavioral problems; managing the feline patient with co-existing and chronic diseases; special medical problems and care considerations for the geriatric cat; environmental enrichment for the indoor cat; feline zoonotic agents and implications for human health; and humane solutions for shelter medicine and overpopulation challenges. - Helps meet the increasing demand for state-of-the-art medical care by cat owners, including advanced diagnostic services and treatments designed to extend and improve quality of life for feline companions. - Features a full-color design with hundreds of schematic drawings, tables, boxes, key points, algorithms, and photographs for quick and easy access to information. - Provides in-depth information on indoor cats and senior cats, including timely guidance on meeting owners'expectations for longer, healthier lives for their cats. - Addresses the challenges of cat overpopulation, particularly humane approaches to improve quality of life for millions of feral and community cats and minimize their impact on public health and endangered species of animals. - Presents information written in the manner of expanded conference proceedings, delivering the latest insights and most current approaches to management of feline medical disorders. - Includes contributions from approximately 80 contributors, including many from outside the US, to provide a global perspective and valuable expertise from those most knowledgeable in the field of feline medical care.
- Published
- 2025
7. Pediatric Myeloid Neoplasms With UBTF Tandem Duplications: Morphologic, Immunophenotypic, and Clinical Characterization.
- Author
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Khanlari M, Wang W, Ni Y, Mead PE, Umeda M, Westover T, Ma J, Rubnitz JE, Barajas JM, Pounds S, and Klco JM
- Abstract
Tandem duplications (TDs) in exons of upstream binding transcription factor (UBTF-TD) are a rare recurrent alteration in pediatric and adult acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)/neoplasm. Although recently identified, AML with UBTF-TD is now considered a distinct subtype of AML. To further our understanding of myeloid neoplasms with UBTF-TD, we analyzed clinical, morphologic, and immunophenotypic characteristics of 27 pediatric patients with UBTF-TD-positive myeloid neoplasm, including 21 diagnosed as AML and 6 as MDS. Our data demonstrated that UBTF-TD is frequently associated with cytopenia, hypercellular marrow with erythroid hyperplasia, and trilineage dysplasia. Blasts and maturing myeloid cells show a characteristic dysplastic feature with condensed eosinophilic cytoplasm. Blasts have a myeloid or myelomonocytic immunophenotype with a variably dim expression of CD34 and/or CD117, and except for CD7 expression lack a consistent pattern of aberrant lineage-specific antigen expression. Patients with MDS had a lower blast count in the peripheral blood (P = 0.03) and bone marrow (P <0.001) but otherwise had no significant differences in other hematological parameters. Three patients with MDS rapidly progressed to AML in 33, 39, and 210 days from the initial diagnosis and there was no difference in overall survival between patients with MDS and AML (P = 0.18). Our data suggest that MDS with UBTF-TD is prognostically equivalent to AML with UBTF-TD and thus should be considered as a continuum of the same molecularly defined myeloid neoplasm. These collective data also provide morphologic and immunophenotypic clues that can prompt screening for UBTF-TD in patients with MDS or AML., Competing Interests: Conflicts of Interest and Source of Funding: J.M.K. and M.U.: Honorarium, AstraZeneca Japan. J.M.K. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund. For the remaining authors, none were declared., (Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2025
- Full Text
- View/download PDF
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