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A recent study conducted by researchers at Fondazione IRCCS Istituto Neurologico Carlo Besta in Milan, Italy, explores the compensatory mechanisms in Parkinson's disease. The study investigates the relationship between clinical signs, dopamine transporter imaging data, and neurophysiological measures of the primary motor cortex (M1) in patients with Parkinson's disease. The findings suggest that motor compensation involves M1-striatal networks and intercortical connections becoming more effective with the progressive loss of dopaminergic terminals in the putamen. The study highlights the role of cortical plasticity in balancing these motor networks. [Extracted from the article]