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Facile fabrication of solid oxide electrodes with highly orderly hierarchical channels and active triple-phase boundary still remains a great challenge. In this work, an ordered interconnected biomimetic porous electrode structure of micron channel and nano functional layer was realized by a simple two-step method using wood as a template. The vertically arranged micro channel of the biomimetic cathode allows rapid diffusion between water vapor and hydrogen, greatly reducing the concentration polarization of the cathode. A wealth of three-phase boundary formed by the micron channel and the nano-nickel catalytic layer on its surface provides more reaction sites for water molecule decomposition. In addition, the ordered cathode structure better adapts to the intermittent energy storage needs at various time periods, as the nickel in this structure is more difficult to oxidize after cell operation stops. This simple yet effective structure provides a much more feasible approach for designing solid oxide electrolysis cells. [ABSTRACT FROM AUTHOR]

As a quick and affordable experimental technique, the heavy ion irradiation method may quickly learn about the correlation between the degree of amorphization and structural modification of samples with varying ion implantation. Using the heavy ion irradiation technique, the irradiation stability of multiphase ceramic waste made of Ln 2 Zr 2 O 7 /SrZrO 3 was assessed. Here, we found that multiphase ceramic waste forms still exhibit excellent radiation resistance while achieving high capacity and weak selectivity for immobilization of actinide nuclides (simulated by lanthanide elements) and fission products 90Sr (replaced by 89Sr). The analysis of grazing incidence and Raman spectroscopy provides evidence for explaining the radiation damage mechanism caused by 84Kr15+ heavy ions. Analysis of grazing incidence offers proof of the manner and extent of radiation damage brought on by 84Kr15+ ions. The impact and mechanism of crystal structure on radiation resistance in multiphase ceramics are discussed. [ABSTRACT FROM AUTHOR]

Background Previous studies have linked cycling with improved mental wellbeing but these studies tend to use cross-sectional survey data that have small sample sizes and self-reported health measures, and are potentially susceptible to omitted-variable bias and reverse causation. We use an instrumental variable approach and an objective measure of mental ill-health taken from linked administrative data to ask: 'Does cycle commuting reduce the risk of mental ill-health?' Methods Our study links data on commuting in Edinburgh and Glasgow from the Scottish population census with mental health prescriptions from the National Health Service Prescribing Information System records. We use road distance from home to nearest cycle path as an instrumental variable for cycle commuting. Results In total, 378 253 people aged 16–74 years living and working in the City of Edinburgh and Glasgow City council areas at the 2011 census were included in our study; 1.85% of commuters in Glasgow and 4.8% of commuters in Edinburgh cycled to work. Amongst cyclists, 9% had a prescription for mental health compared with 14% amongst non-cyclists. Using a bivariate probit model, we estimate a mean average reduction in prescriptions for antidepressants and/or anxiolytics in the 5 years following the census of –15.1% (95% CI: –15.3% to –15.0%) amongst cycle commuters compared with those who use any other mode to commute. Conclusions This work suggests that cycle commuting is causally related to reduced mental ill-health and provides further evidence in support of the promotion of active travel to encourage commuters travelling shorter distances to shift to cycle commutes. [ABSTRACT FROM AUTHOR]

The present study aims to explore free vibration analysis of hybrid reinforced porous composite plates subjected to fluid loading. The hybrid composite comprises a porous core layer covered by two reinforced porous face sheets. Graphene Platelets (GPLs) and Carbon Nanotubes (CNTs) are considered as reinforcement materials. The linear three-dimensional piezo-elasticity theory is employed to model the structural part of the system, while the classical Rayleigh integral is used to obtain the fluid interaction part. The accuracy and reliability of the proposed model are validated by comparing the calculated natural frequencies of the plate in vacuum and water-loaded conditions with those reported in the literature. For the first time, several parametric studies are performed to investigate the effects of dimension ratios, porosity distributions, reinforcement dispersion pattern, porosity coefficient, and weight fraction of nanofiller on the natural frequency of hybrid reinforced porous composites. The results indicate that adjusting the porosity and weight fraction of the face sheets can enhance stiffness without changing the mass, emphasizing the importance of hybrid composites for achieving optimal stiffness while maintaining a constant mass. Furthermore, the influence of core layer porosity distributions on the composite behavior differs from that of porosity distributions in the face layers. Additionally, the effectiveness of the reinforcement pattern depends on the type of porosity distribution in the face layers. [ABSTRACT FROM AUTHOR]

[Display omitted] The Zagros orogenic belt is a major mountain system located in southwestern Iran and extending into northeastern Iraq and southeastern Turkey. It was formed as a result of the Late Paleogene-Early Neogene Arabian-Eurasian continental collision, where its proto-basin was impacted by the tectonic evolution during the Proto-Tethys and Paleo-Tethys development. The entire evolution history can be summarized through an integrated model of three Wilson cycles. This paper aims to provide an understanding of the complexities of plate motions that led to the evolution of the Zagros Fold-and-Thrust Belt, by integrating the time and space evolution of supercontinents. A comprehensive review of the Arabian plate tectonics suggests three main tectonic stages, including a period of rifting from the Late Cambrian to Carboniferous, a period of ocean closure during the Late Triassic and Jurassic, and a final collision during the Cenozoic. These tectonic evolution stages encompassed multiple episodes of basin uplifting and subsidence, marked by wide-spread fault reactivation and fold deformation. Three styles of deformation were identified and characterized, including thin-skinned, thick-skinned, and basement deformation. The closure of the Neo-Tethys Ocean resulted in compressional tectonics that reactivated dormant faults, and emplaced gypsum-salt sedimentary caprock. The genetic analysis concurrently proposes a scientific framework for the characterization of structural deformation in similar convergent plate systems globally. [ABSTRACT FROM AUTHOR]

Some evidence from Western high-income countries suggests local tobacco retail availability and neighbourhood deprivation may influence smoking behaviours. However, this assertion has not been considered in China, where 44% of males continue to smoke. Data were analysed from Chinese males (n = 2054) who participated in Waves 3–5 (2009–2015) of the International Tobacco Control (ITC) China Survey by linking information on tobacco retail availability (estimated through population weighted Kernel Density of tobacco retailers in 2019) and neighbourhood deprivation (calculated as a composite score derived from the 2010 Chinese census) across Shanghai. Generalised Estimating Equation models were fitted to examine the impacts of local tobacco availability and neighbourhood deprivation on smoking behaviours (current smoking versus current non-smoking, quitting versus current smoking, longer durations of smoking abstinence versus current smoking) using the longitudinal data. Examining the impacts separately, participants living in neighbourhoods with greater availability and higher levels of deprivation were less likely to maintain longer durations of smoking abstinence in both unadjusted and adjusted models. Neighbourhood deprivation, but not availability, was found to be associated with higher odds of being a current smoker. Examining the impacts jointly, neighbourhood deprivation was still positively associated with current smoking and negatively associated with longer durations of smoking abstinence, but the negative association between availability and longer durations of smoking abstinence disappeared. The findings offer some evidence that greater tobacco retail availability and deprivation are obstacles on prolonged smoking cessation among males in Shanghai, China. Policymakers should consider small-area level place-based restrictions in China, such as reducing the availability of tobacco, as part of a comprehensive tobacco control strategy aimed at addressing the high prevalence of smoking. • This work examines how tobacco retail availability and neighbourhood deprivation affect a series of smoking behaviours in Shanghai, China, using a cohort of male samples. • Neighbourhood deprivation was positively associated with current smoking and negatively associated with smoking cessation. • Examining the impacts of availability and deprivation jointly, the significant association between local tobacco retail availability and smoking cessation was no longer retained. • Regulating tobacco retail availability at the neighbourhood level may have the potential to reduce smoking prevalence. [ABSTRACT FROM AUTHOR]

The Northeast China Block is a major component of the Central Asian Orogenic Belt, and its tectonic evolution has attracted much research attention. Ordovician strata are important in reconstructing the tectonic evolution of the Northeast China Block. This paper presents the results of sedimentological, zircon U–Pb, and geochemical analyses of sandstones of the Luohe Formation in the Wunuer area, Northern Great Xing'an Range, Northeast China. Lithological data, sedimentary structures, and grain-size analysis indicate that the Luohe Formation was deposited in a shallow marine environment. Detrital zircon U–Pb dating yields age peaks of 463, 504, 783, 826, 973, and 1882 Ma for sandstones from the Luohe Formation. The youngest zircon grain age of 451 ± 6 Ma represents the maximum depositional age of the Luohe Formation. The peak age at 463 Ma is consistent with the timing of post-collisional magmatism and the formation of the Duobaoshan island arc, while the peak at 504 Ma is consistent with the timing of magmatic activity related to the collision between the Erguna and Xing'an blocks. The peaks at 788, 826, 973, and 1882 Ma correspond to magmatism in the Erguna block, these ages indicate that the sandstones of the Luohe Formation were derived mainly from the Erguna block. Sandstone modal compositional analysis indicates that the provenance of the Luohe Formation was mainly a magmatic arc. The geochemical compositions of the sandstones suggest that the source rocks have continental island arc signatures. Based on the depositional age, sedimentary environment, provenance, and regional geology, it is concluded that the Luohe Formation was deposited in a back-arc basin setting during the formation of the Duobaoshan island arc–basin system in response to subduction of the Paleo-Asian oceanic plate. [ABSTRACT FROM AUTHOR]

This retrospective cohort study aimed to identify baseline patient characteristics involving modifiable lifestyle factors that are associated with the development of colorectal adenomas, and establish and validate a nomogram for risk predictions among high-risk populations with negative index colonoscopy. A total of 83,076 participants who underwent an index colonoscopy at the Tianjin Union Medical Center between 2004 and 2019 were collected. According to meticulous inclusion and exclusion criteria, 249 subjects were enrolled and categorized into the primary and validation cohorts. Based on the primary cohort, we utilized the LASSO-Cox regression and the univariate/multivariate Cox proportional hazards (Cox-PH) regression parallelly to select variables, and incorporated selected variables into two nomogram models established using the multivariate Cox-PH regression. Comparison of the Akaike information criterion and the area under the receiver operating characteristic curve of the two models demonstrated that the nomogram model constituted by four covariates retained by the LASSO-Cox regression, including baseline age, body mass index, physical activity and family history of colorectal cancer (CRC) in first-degree relatives, performed better at predicting adenoma-free survival probabilities. Further validation including the concordance index, calibration plots, decision curve analysis and Kaplan–Meier survival curves also revealed good predictive accuracy, discriminating ability, clinical utility and risk stratification capacity of the nomogram model. Our nomogram will assist high-risk individuals with negative index colonoscopy to prevent colorectal adenoma occurrence and CRC morbidity with improved cost-effectiveness. [ABSTRACT FROM AUTHOR]

In response to the low separation efficiency of actinide nuclide (An) and fission product (FP) in the separation process of high‐level radioactive waste, as well as the large amount of secondary waste. A novel Ln(1‐x)SrxZrO(3.5‐0.5x) (0 ≤ x ≤1) multiphase ceramic waste form (Nd3+ simulating An3+), which can cure both An and Sr simultaneously, was in‐situ synthesized by sol‐gel spray pyrolysis method. The series of multiphase ceramics are composed of cubic pyrochlore phase Nd2Zr2O7 (NZO) and orthorhombic perovskite phase SrZrO3 (SZO), without any accompanying impurities. The two phases exhibit excellent compatibility, and their content can change regularly with the change of x. Nd and Sr occupy their most stable crystal lattice positions, with low transposition doping levels. The density of the composite ceramics is high, and the measured density is as high as 88 % of the theoretical density. The above experimental results confirm that the new multiphase ceramics can cure An and Sr simultaneously and separately, showing strong adaptability to waste components and high chemical stability. [ABSTRACT FROM AUTHOR]

While the delay in adjuvant chemotherapy (AC) is known to impact colon cancer outcomes, its effect on rectal cancer is less clear. This study aims to evaluate the influence of AC timing on survival in stage II and III rectal cancer. This retrospective multicenter study enrolled 1,144 patients receiving chemotherapy following resection of stage II–III rectal cancers. The effect of delayed AC on survival was assessed using multivariable Cox models with restricted cubic splines and logistic regression. Compared to patients initiating AC within four weeks postsurgery, those initiating within 5–8 weeks had a similar survival (HR=0.85, 95 % CI=0.66–1.11), whereas those initiating within 8–12 weeks (HR=1.62, 95 % CI=1.05–2.51) or beyond 12 weeks (HR=2.07, 95 % CI=1.21–3.56) had a significantly inferior survival. A delayed time to chemotherapy (>8 weeks) was associated with worse survival in patients aged ≥60 years but not in younger patients (<60 years: HR=1.36; 95 % CI=0.75–2.46, p=0.312; ≥60 years: HR=2.37; 95 % CI=1.56–3.60, p<0.001). Additionally, our exploratory analysis suggested that FOLFOX and FOLFIRI were more effective when starting within 5–8 weeks post-surgery, while CAPEOX and a single agent showed a slight advantage when starting within four weeks. Our findings advocate for initiating AC within eight weeks post-surgery in stage II–III rectal cancer, especially in older patients. Delayed treatment is linked to significantly worse survival outcomes. [ABSTRACT FROM AUTHOR]

Air pollution increases the risk of mortality and morbidity. However, limited evidence exists on the very long-term associations between early life air pollution exposure and health, as well as on potential pathways. This study explored the relationship between fine particle (PM 2.5) exposure at age 3 and limiting long-term illness (LLTI) at ages 55, 65 and 75 using data from the Scottish Longitudinal Study Birth Cohort 1936, a representative administrative cohort study. We found that early life PM 2.5 exposure was associated with higher odds of LLTI in mid-to-late adulthood (OR = 1.10, 95% CI: 1.06, 1.14 per 10 μg m−3 increment) among the 2085 participants, with stronger associations among those growing up in disadvantaged families. Path analyses suggested that 15–21% of the association between early life PM 2.5 concentrations and LLTI at age 65 (n = 1406) was mediated through childhood cognitive ability, educational qualifications, and adult social position. Future research should capitalise on linked administrative and health data, and explore causal mechanisms between environment and specific health conditions across the life course. • The life-course impact of early life air pollution on health and healthy ageing is not fully understood. • PM 2.5 concentrations at age 3 were linked to a 1936-born cohort using administrative records. • Higher early life PM 2.5 exposure was associated with limiting long-term illness in mid-to-late adulthood. • Associations were stronger among individuals growing up in disadvantaged families. • Part of the association was mediated through cognitive and social pathways. [ABSTRACT FROM AUTHOR]

Background: Aberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicing factor component of U2 small nuclear ribonucleoproteins which are crucial for early stages of spliceosome assembly. The role of SF3B3 in CRC remains unknown. Methods: SF3B3 expression in human CRCs was analyzed using publicly available CRC datasets, immunohistochemistry, qRT-PCR, and western blot. RNA-seq, RNA immunoprecipitation, and lipidomics were performed in SF3B3 knockdown or overexpressing CRC cell lines. CRC cell xenografts, patient-derived xenografts, patient-derived organoids, and orthotopic metastasis mouse models were utilized to determine the in vivo role of SF3B3 in CRC progression and metastasis. Results: SF3B3 was upregulated in CRC samples and associated with poor survival. Inhibition of SF3B3 by RNA silencing suppressed the proliferation and metastasis of CRC cells in vitro and in vivo, characterized by mitochondria injury, increased reactive oxygen species (ROS), and apoptosis. Mechanistically, silencing of SF3B3 increased mTOR exon-skipped splicing, leading to the suppression of lipogenesis via mTOR-SREBF1-FASN signaling. The combination of SF3B3 shRNAs and mTOR inhibitors showed synergistic antitumor activity in patient-derived CRC organoids and xenografts. Importantly, we identified SF3B3 as a critical regulator of mTOR splicing and autophagy in multiple cancers. Conclusions: Our findings revealed that SF3B3 promoted CRC progression and metastasis by regulating mTOR alternative splicing and SREBF1-FASN-mediated lipogenesis, providing strong evidence to support SF3B3 as a druggable target for CRC therapy. [ABSTRACT FROM AUTHOR]

A facile and eco‐friendly dimethyl sulfoxide‐mediated solution aging (DMSA) treatment is presented to control the crystallization dynamics of methylammonium (MA)‐free wide‐bandgap (WBG) perovskite films, enhancing film quality, and morphology for high‐performance tandem solar cells. The comprehensive structural, morphological, and characterization analyses reveal that the DMSA treatment significantly enhances composition and morphology homogeneity while suppressing halide segregation. Consequently, opaque, and semi‐transparent MA‐free WBG perovskite solar cells (PSCs) exhibit remarkable power conversion efficiencies (PCEs) of 18.28% and 17.61%, respectively. Notably, the unencapsulated DMSA‐treated devices maintain 95% of the initial PCE after 900 h of continuous operation at 55 °C ± 5 °C. Furthermore, stacking semi‐transparent DMSA‐treated PSCs as top cells in a 4T tandem configuration, along with silicon heterojunction (SHJ), lead–tin (Pb–Sn) alloyed PSCs, and organic photovoltaics (OPV) as bottom cells, yields impressive PCEs of 28.09%, 26.09%, and 25.28%, respectively, for the fabricated tandem cells. This innovative approach opens new avenues for enhancing the photo‐stability and photovoltaic performance of perovskite‐based tandem solar cells. [ABSTRACT FROM AUTHOR]

In computational non-Newtonian fluid dynamics, heat transfer has obvious effects on motions of viscoelastic fluids, mechanical mechanism of elasticity, and flow regimes. This study suggests an extended numerical scheme of smoothed particle hydrodynamics and finite particle method within density smoothing (SPH_DSFPM), which involves the discretization of smoothed particle hydrodynamics (SPH) and finite particle method (FPM) within density smoothing (DS) in the weakly compressible flow scheme. A corrected particle shifting technique is incorporated to eliminate tensile instability and inhomogeneity near solid boundaries. A corrected dynamic solid coupled boundary is introduced to deal with casting molding within high-pressure operations, which has a good compatibility between virtual particle method and repulsive force model. Numerical results show that the present scheme has the nearly lower relative error (0.5%) than conventional SPH (2.6%) in the case of evolutionary thermal-viscoelastic Poiseuille flow and heat effects have active influences on velocity, pressure variations for viscoelastic fluid flow around periodic circular cylinders. Three different printing modes of moving printers significantly generate into differentiated forming regimes through high-pressure extrusion. Adaptive particle distributions possess robust flow evolutions, by which the shocked jets can be tracked well and the sinking velocities of wedge entering into solutions can be numerically probed well considering different cuspidal biting angles. In the case of macroscopic fluid–rigid body interactions, the statistical degree of deviation on probed forces with experiments is relatively 4.35% and that is 12.5% for SPH. The proposed numerical scheme has a good performance on improved accuracy, convergence, and stability for simulating transient thermal-viscoelastic flows. [ABSTRACT FROM AUTHOR]

In this study, we introduce a novel framework for the semantic segmentation of point clouds in autonomous driving scenarios, termed PVI-Net. This framework uniquely integrates three different data perspectives—point clouds, voxels, and distance maps—executing feature extraction through three parallel branches. Throughout this process, we ingeniously design a point cloud–voxel cross-attention mechanism and a multi-perspective feature fusion strategy for point images. These strategies facilitate information interaction across different feature dimensions of perspectives, thereby optimizing the fusion of information from various viewpoints and significantly enhancing the overall performance of the model. The network employs a U-Net structure and residual connections, effectively merging and encoding information to improve the precision and efficiency of semantic segmentation. We validated the performance of PVI-Net on the SemanticKITTI and nuScenes datasets. The results demonstrate that PVI-Net surpasses most of the previous methods in various performance metrics. [ABSTRACT FROM AUTHOR]

The extent to which populations will successfully adapt to continued warming temperatures will be a crucial factor in determining future health burdens. Previous health impact assessments of future temperature-related mortality burdens mostly disregard adaptation or make simplistic assumptions. We apply a novel evidence-based approach to model adaptation that takes into account the fact that adaptation potential is likely to vary at different temperatures. Temporal changes in age-specific mortality risk associated with low and high temperatures were characterised for Scotland between 1974 and 2018 using temperature-specific RR ratios to reflect past changes in adaptive capacity. Three scenarios of future adaption were constructed consistent with the SSPs. These adaptation projections were combined with climate and population projections to estimate the mortality burdens attributable to high (above the 90th percentile of the historical temperature distribution) and low (below the 10th percentile) temperatures up to 2080 under five RCP-SSP scenarios. A decomposition analysis was conducted to attribute the change in the mortality burden into adaptation, climate and population. In 1980–2000, the heat burden (21 deaths/year) was smaller than the colder burden (312 deaths/year). In the 2060–2080 period, the heat burden was projected to be the highest under RCP8.5-SSP5 (1285 deaths/year), and the cold burden was the highest under RCP4.5-SSP4 (320 deaths/year). The net burden was lowest under RCP2.6-SSP1 and highest under RCP8.5-SSP5. Improvements in adaptation was the largest factor reducing the cold burden under RCP2.6-SSP1 whilst temperature increase was the biggest factor contributing to the high heat burdens under RCP8.5-SSP5. Ambient heat will become a more important health determinant than cold in Scotland under all climate change and socio-economic scenarios. Adaptive capacity will not fully counter projected increases in heat deaths, underscoring the need for more ambitious climate mitigation measures for Scotland and elsewhere. • A novel evidence-based approach is used to reflect adaptation to extreme temperatures. • Future health burdens associated with extreme temperatures are affected by adaptation. • The projected deaths related to extreme heat are higher than cold in Scotland by 2080. • More than half of the increase in the heat burden by 2080 is attributable to global warming. • The net temperature burden is lowest under RCP2.6-SSP1 and highest under RCP8.5-SSP5. [ABSTRACT FROM AUTHOR]

Steroid hybrids have emerged as a type of advantageous compound as they could offer improved pharmacological and pharmaceutical properties. Here, we report a series of novel peptide–dehydroepiandrosterone hybrids, which would effectively induce endoplasmic reticulum stress (ERS) and lead to apoptosis with outstanding in vitro and in vivo anti-melanoma effects. The lead compound IId among various steroids conjugated with peptides and pyridines showed effective in vivo activity in B16 xenograft mice: in medium- and high-dose treatment groups (60 and 80 mg/kg), compound IId would significantly inhibit the growth of tumours by 98%–99% compared to the control group, with the highest survival rate as well. Further mechanism studies showed that compound IId would damage the endoplasmic reticulum and upregulate the ERS markers C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78), which could further regulate caspase and Bcl-2 family proteins and lead to cell apoptosis. The compound IId was also proven to be effective in inhibiting B16 cell migration and invasion. This paper reports a series of peptide-dehydroepiandrosterone (DHEA) conjugates with the ability to damage endoplasmic reticulum and upregulate endoplasmic reticulum stress markers which finally leads to apoptosis in melanoma. The lead compound IId has IC 50 of 9.70 μM against B16 melanoma cell line and the tumour-inhibitory rate in vivo was 98% after 27 days treatment in 0.06–0.08 mg/g dose groups and also demonstrated a good dose-effect and time-effect relationship. [Display omitted] • A series of novel peptide-dehydroepiandrosterone hybrids were synthesised. • Peptidyl modifications provided dehydroepiandrosterone derivatives with the ability to suppress melanoma both in vitro and in vivo. • The lead compound IId would trigger endoplasmic reticulum stress to induce apoptosis in B16 cells. • In xenograft model, IId (60 mg/kg and 80 mg/kg groups) would inhibit the growth of tumour by 98%–99% compared to control. [ABSTRACT FROM AUTHOR]

Filling a borehole with proper grout is important for maintaining the safety and performance of borehole heat exchangers (BHEs). The current grouts have problems of large shrinkage and low thermal conductivity, which may restrain BHE efficiency and pose safety risks. To address this, this study explores solutions to enhance the thermal and sealing performance of cement-based grout, specifically for BHE applications. A novel grout, composed of ordinary Portland cement (OPC)-calcium sulfoaluminate (CSA) cement-gypsum ternary system and graphite, was developed and thoroughly examined. The developed grout exhibited good flowability and volumetric stability, meeting the required compressive strength in one day. It displayed high thermal conductivity, ranging from 1.606 to 2.504 W/mK at oven-dry conditions and 2.173 to 3.532 W/mK at saturated conditions. At last, numerical modeling was conducted to compare the thermal performance of boreholes using the novel grout developed in this study and a conventional grout. Numerical models prove that using developed grout can improve the thermal performance of boreholes and decrease the borehole resistance, thus lessening the required borehole length, further reducing the costs and carbon emissions of borehole construction. Overall, the developed grouts showcased enhanced thermal and sealing performance. They can be applied in BHE systems not only to enhance operational efficiency and safety, but also to reduce costs and carbon footprints. [ABSTRACT FROM AUTHOR]