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Your search keyword '"Genovese, Giannicola"' showing total 6 results
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6 results on '"Genovese, Giannicola"'

1. Mitochondrial complex I promotes kidney cancer metastasis

Author

Bezwada, Divya, Perelli, Luigi, Lesner, Nicholas P., Cai, Ling, Brooks, Bailey, Wu, Zheng, Vu, Hieu S., Sondhi, Varun, Cassidy, Daniel L., Kasitinon, Stacy, Kelekar, Sherwin, Cai, Feng, Aurora, Arin B., Patrick, McKenzie, Leach, Ashley, Ghandour, Rashed, Zhang, Yuanyuan, Do, Duyen, McDaniel, Phyllis, Sudderth, Jessica, Dumesnil, Dennis, House, Sara, Rosales, Tracy, Poole, Alan M., Lotan, Yair, Woldu, Solomon, Bagrodia, Aditya, Meng, Xiaosong, Cadeddu, Jeffrey A., Mishra, Prashant, Garcia-Bermudez, Javier, Pedrosa, Ivan, Kapur, Payal, Courtney, Kevin D., Malloy, Craig R., Genovese, Giannicola, Margulis, Vitaly, and DeBerardinis, Ralph J.

Published
2024
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2. Clonal dominance defines metastatic dissemination in pancreatic cancer

Author

Ho, I-Lin, primary, Li, Chieh-Yuan, additional, Wang, Fuchenchu, additional, Zhao, Li, additional, Liu, Jingjing, additional, Yen, Er-Yen, additional, Dyke, Charles A., additional, Shah, Rutvi, additional, Liu, Zhaoliang, additional, Çetin, Ali Osman, additional, Chu, Yanshuo, additional, Citron, Francesca, additional, Attanasio, Sergio, additional, Corti, Denise, additional, Darbaniyan, Faezeh, additional, Del Poggetto, Edoardo, additional, Loponte, Sara, additional, Liu, Jintan, additional, Soeung, Melinda, additional, Chen, Ziheng, additional, Jiang, Shan, additional, Jiang, Hong, additional, Inoue, Akira, additional, Gao, Sisi, additional, Deem, Angela, additional, Feng, Ningping, additional, Ying, Haoqiang, additional, Kim, Michael, additional, Giuliani, Virginia, additional, Genovese, Giannicola, additional, Zhang, Jianhua, additional, Futreal, Andrew, additional, Maitra, Anirban, additional, Heffernan, Timothy, additional, Wang, Linghua, additional, Do, Kim-Anh, additional, Gargiulo, Gaetano, additional, Draetta, Giulio, additional, Carugo, Alessandro, additional, Lin, Ruitao, additional, and Viale, Andrea, additional

Published
2024
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4. Abstract A011: DPY30 regulates immunoediting by suppressing uncoordinated DNA replication in pancreatic cancer

Author

Citron, Francesca, primary, Perelli, Luigi, additional, Balestrieri, Chiara, additional, Cecchetto, Luca, additional, Chu, Yanshuo, additional, Ho, I-Lin, additional, Zhang, Li, additional, Yen, Er-Yen, additional, Montanez, Luis Castillo, additional, Shah, Rutvi, additional, Attanasio, Sergio, additional, Srinivasan, Sanjana, additional, Dyke, Charles, additional, Chen, Ko-Chien, additional, Jiang, Shan, additional, Pan, Jing, additional, Gao, Sisi, additional, Wang, Huamin, additional, Yao, Wantong, additional, Wang, Linghua, additional, Pilato, Mauro Di, additional, Genovese, Giannicola, additional, Viale, Andrea, additional, and Draetta, Giulio, additional

Published
2024
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5. The KRAS mutational spectrum and its clinical implications in pancreatic cancer.

Author

Perelli, Luigi, Genovese, Giannicola, and Draetta, Giulio F.

Subjects
*PANCREATIC duct, *DISEASE progression, *RAS oncogenes, *PANCREATIC cancer, *CANCER cells
Abstract

In this issue of Cancer Cell , McIntyre et al. show that specific mutations in the KRAS proto-oncogene shape clinical progression of pancreatic ductal adenocarcinoma (PDAC). Importantly, they find that the KRAS G12R mutation is enriched in early-stage PDAC, and it is characterized by distinctly activated molecular programs. [ABSTRACT FROM AUTHOR]

Published
2024
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6. WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer.

Author

Citron F, Ho IL, Balestrieri C, Liu Z, Yen EY, Cecchetto L, Perelli L, Zhang L, Montanez LC, Blazanin N, Dyke CA, Shah R, Attanasio S, Srinivasan S, Chen KC, Chen Z, Scognamiglio I, Pham N, Khan H, Jiang S, Pan J, Vanderkruk B, Leung CS, Mattohti M, Rai K, Chu Y, Wang L, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Xiong Y, Lorenzi PL, Bonini C, Anna Zal M, Hoffman BG, Heffernan T, Giuliani V, Jeter CR, Lissanu Y, Genovese G, Pilato MD, Viale A, and Draetta GF

Abstract

It is unclear how cells counteract the potentially harmful effects of uncoordinated DNA replication in the context of oncogenic stress. Here, we identify the WRAD (WDR5/RBBP5/ASH2L/DPY30) core as a modulator of DNA replication in pancreatic ductal adenocarcinoma (PDAC) models. Molecular analyses demonstrated that the WRAD core interacts with the replisome complex, with disruption of DPY30 resulting in DNA re-replication, DNA damage, and chromosomal instability (CIN) without affecting cancer cell proliferation. Consequently, in immunocompetent models, DPY30 loss induced T cell infiltration and immune-mediated clearance of highly proliferating cancer cells with complex karyotypes, thus improving anti-tumor efficacy upon anti-PD-1 treatment. In PDAC patients, DPY30 expression was associated with high tumor grade, worse prognosis, and limited response to immune checkpoint blockade. Together, our findings indicate that the WRAD core sustains genome stability and suggest that low intratumor DPY30 levels may identify PDAC patients who will benefit from immune checkpoint inhibitors.

Published
2024
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