1. Sex hormone binding globulin (SHBG) serum levels and insulin resistance in men on chronic hemodialysis
- Author
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Evdokia Nikolaou, Maria Tziastoudi, Sofia G. Gougoura, Georgios Filippidis, Periklis Dousdampanis, Alexandra Bargiota, Peter Rene Mertens, Theodoros Eleftheriadis, Georgios M. Hadjigeorgiou, Georgios N. Koukoulis, and Ioannis Stefanidis
- Subjects
Estradiol ,Hemodialysis ,Homeostasis model ,Insulin resistance ,Male hypogonadism ,Testosterone ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background In males with end stage renal disease biochemical hypogonadism is a frequent finding. Testosterone and sex hormone binding globulin (SHBG) have been associated with insulin resistance, a well-known condition in uremia. The aim of the present study was to investigate in males on chronic hemodialysis the relationship of testosterone and SHBG serum levels with insulin resistance. Methods In a cross-sectional study we enrolled men treated with chronic hemodialysis who did not suffer from an acute illness or other endocrinopathy, as well as primary hypogonadism, and were not hospitalised. Diabetes mellitus, diabetic nephropathy or previous transplantation were not exclusion criteria. As controls we used a community-based group of healthy males matched for age and Body Mass Index (BMI). We assessed the BMI (kg/m2) from body weight and height, the body fat content (%) by bioelectrical impedance and serum testosterone (ng/ml), SHBG (nmol/L) and estradiol (pg/ml) by standard methods. Testosterone
- Published
- 2024
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