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A new study conducted at the Medical University Vienna has found that serum trefoil factor-3 (TFF3) can predict survival in peripheral artery disease (PAD). The study measured TFF3 levels in the serum of 364 PAD patients and found a negative association between ankle-brachial index and TFF3. TFF3 was also associated with cardiovascular and cerebrovascular disease, renal function, and additional atherosclerotic burden in PAD. The study concluded that an increase in TFF3 was linked to a higher risk of all-cause mortality. This research provides valuable insights into the potential use of TFF3 as a biomarker for predicting outcomes in PAD. [Extracted from the article]