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2 results on '"Grome, Heather N"'

1. Carbapenem-Resistant and Extended-Spectrum [beta]-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020

Author

Grome, Heather N., Grass, Julian E., Duffy, Nadezhda, Bulens, Sandra N., Ansari, Uzma, Campbell, Davina, Lutgring, Joseph D., Gargis, Amy S., Masters, Thao, Kent, Alyssa G., McKay, Susannah L., Smith, Gillian, Wilson, Lucy E., Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin, Flores, Kristina, Wilson, Christopher D., Czaja, Christopher A., Johnston, Helen, Janelle, Sarah J., Lynfield, Ruth, OMalley, Sean, Vagnone, Paula Snippes, Maloney, Meghan, Nadle, Joelle, and Guh, Alice Y.

Subjects
Medical research, Medicine, Experimental, Enterobacteriaceae infections -- Drug therapy -- Diagnosis, Drug resistance in microorganisms -- Testing, Communicable diseases in children -- Drug therapy -- Diagnosis, Health
Abstract

Medscape CME Activity In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited with commendation [...]

Published
2024
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2. Carbapenem-Resistant and Extended-Spectrum β-Lactamase--Producing Enterobacterales in Children, United States, 2016-2020.

Author

Grome, Heather N., Grass, Julian E., Duffy, Nadezhda, Bulens, Sandra N., Ansari, Uzma, Campbell, Davina, Lutgring, Joseph D., Gargis, Amy S., Masters, Thao, Kent, Alyssa G., McKay, Susannah L., Smith, Gillian, Wilson, Lucy E., Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin, Flores, Kristina, and Wilson, Christopher D.

Abstract

We conducted surveillance for carbapenem-resistant Enterobacterales (CRE) during 2016-2020 at 10 US sites and extended-spectrum β-lactamase--producing Enterobacterales (ESBL-E) during 2019-2020 at 6 US sites. Among 159 CRE cases in children (median age 5 years), CRE was isolated from urine for 131 (82.4%) and blood from 20 (12.6%). Annual CRE incidence rate (cases/ 100,000 population) was 0.47-0.87. Among 207 ESBLE cases in children (median age 6 years), ESBL-E was isolated from urine of 196 (94.7%) and blood of 8 (3.9%). Annual ESBL-E incidence rate was 26.5 in 2019 and 19.63 in 2020. CRE and ESBL-E rates were >2-fold higher among infants than other age groups. Most CRE and ESBL-E cases were healthcare-associated community-onset (68 [43.0%] for CRE vs. 40 [23.7%] for ESBL-E) or community-associated (43 [27.2%] for CRE vs. 109 [64.5%] for ESBL-E). Programs to detect, prevent, and treat multidrugresistant infections must include pediatric populations (particularly the youngest) and outpatient settings. [ABSTRACT FROM AUTHOR]

Published
2024
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