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Abstract Background Cytoreductive radical prostatectomy (cRP) has emerged as a promising therapeutic approach for low-volume metastatic hormone-sensitive prostate cancer (mHSPC), but the best candidates for cRP are still unknown. This study aims to explore the potential value of 18F-PSMA-1007 PET/CT-derived quantitative volumetric tumor parameters in cRP treatment selection among patients with low-volume mHSPC. Methods A total of 122 patients with primary low-volume mHSPC who underwent 18F-PSMA-1007 PET/CT followed by systemic therapy alone or plus cRP were included. The whole-body PSMA-derived tumor volume (PSMA-TV) was defined as the total volume of whole-body PSMA-avid tumor lesions, and prostate PSMA-TV was defined as the volume of prostate PSMA-avid tumor lesions. Spearman’s correlation was used to analyze the relationships between whole-body PSMA-TV and clinicopathological characteristics. The primary endpoint was progression-free survival (PFS), and Cox regression analyses were performed to explore the independent predictors for PFS. Results Among 122 patients, 37 (30.32%) underwent systemic therapy plus cRP. The median and optimal cutoff values of the whole-body PSMA-TV were 71.68 cm3 (41.28–157.41 cm3) and 78.57 cm3, respectively. Whole-body PSMA-TV was positively correlated with prostate-specific antigen (PSA), and patients with nonregional lymph node (NRLN) metastases had a greater whole-body PSMA-TV (P = 0.001). Cox regression analyses revealed that cRP, lower whole-body PSMA-TV and the absence of NRLN metastases were associated with better PFS (all P

This study evaluated the efficiency of the logistics industry in Shijiazhuang City by using the DEA-BCC and Malmquist index models to analyse efficiency changes from 2010 to 2019 and compared them with seven logistics hub cities in the eastern region. The results indicate that Shijiazhuang’s logistics efficiency is high, with leading technology and management levels in the eastern region. Additionally, the Tobit regression model was used to explore factors affecting Shijiazhuang’s logistics efficiency, finding that economic development and locational advantages positively influence logistics efficiency, whereas industrial structure has a negative impact. Based on these findings, it is recommended that Shijiazhuang City enhance its logistics efficiency by improving logistics infrastructure, developing multimodal transport, leveraging locational advantages, elevating economic levels and openness, advancing logistics informatisation and nurturing high-quality logistics talent.

Abstract Objective Osteoporosis increases the risk of fragility fractures, impacting patients’ lives. This study aimed to investigate whether LINC01271 was involved in the process of fragility fractures and healing, providing a new perspective for its diagnosis and treatment. Methods This study included 94 healthy individuals, 82 patients with osteoporosis, and 85 patients with fragility fractures as subjects. RT-qPCR was used to measure the levels of LINC01271, miR-19a-3p, PIK3CA, and osteogenic differentiation markers in osteoblasts and subjects’ serum. Luciferase reporter assays, RIP experiments, and RNA pull-down assays were utilized to verify the target relationships between LINC01271 and miR-19a-3p, as well as between miR-19a-3p and PIK3CA. Cell proliferation and apoptosis were assessed using CCK-8 assays and flow cytometry. Results Compared to the healthy control group, the serum levels of LINC01271 were significantly reduced in patients with osteoporosis and fragility fractures. Furthermore, LINC01271 levels increased with time-dependent fracture healing. In vitro studies indicated that LINC01271 boosted osteoblast proliferation, inhibited apoptosis, and augmented osteogenic differences, whereas its inhibition reverses their effects. LINC01271 and PIK3CA were identified as targets of miR-19a-3p, and overexpression of miR-19a-3p could antagonize the effect of LINC01271 in promoting fracture healing. Conclusion The results indicated that LINC01271 may play a key role in osteoblast function and fracture healing through its interaction with miR-19a-3p and regulation of PIK3CA.

To further regulate the coordinated matching of mechanical properties and plastic deformation ability of Al2O3/Cu composites. In this paper, Al2O3/Cu-Cr composites with different Cr contents were prepared by replacing some Al2O3 particles with Cr using a deformation heat treatment process, and the effects of Cr contents on the microstructure, electrical conductivity, and mechanical properties of Al2O3/Cu-Cr composites were investigated with a focus on the contribution of the composite strengthening mechanism. The results show that with the increase of Cr content and the decrease of Al2O3 content, the strength of the composites gradually decreases, and the plasticity and electrical conductivity are enhanced. Among them, the elongation of 1.1 Al2O3/Cu-0.3Cr composites was enhanced from 10% to 15% while the strength was not considerably reduced. The addition of Cr promotes grain growth and dynamic recrystallization, whereas Al2O3 particles enhance the aging precipitation response of Cr particles. The results of strength mechanism calculations show that the tensile strength of Al2O3/Cu-Cr composites mainly consists of Orowan strengthening caused by Al2O3 particles and dislocation strengthening in cold rolled deformation, while the dislocation strengthening is weakened at higher Cr content.

Abstract Alcohol‐related liver disease (ALD) is a common chronic liver disease caused by long‐term excessive alcohol consumption and responsible for more than half of all liver‐related deaths worldwide. The molecular mechanisms associated with ALD were not fully understood. In this study, we performed single‐cell RNA sequencing on liver tissues obtained from ALD patients and healthy liver donors. We identified an ALB+KRT7+ epithelial population that expressed both hepatocyte and biliary markers significantly expanded in ALD livers. The ALB+KRT7+ epithelial cells were demonstrated to have stem cell properties and malignant transformation potentials. Moreover, ALB+KRT7+ epithelium‐derived ALD organoids promote the tumour growth by activating Wnt/β‐catenin signalling of liver cancer cells. Most importantly, blocking the Wnt protein secretion or knockdown the Wnt receptor suppressed the tumour promoting effect of ALD organoids. Our study provides important insights that Wnt signalling can be targeted in patients with advanced alcohol‐related cirrhosis to prevent malignant transformation. In addition, our results also uncovered the important alterations of nonparenchymal cells, especially macrophages and T/NK populations that responsible for active inflammation responses in alcohol‐related hepatitis and immunosuppressive microenvironment in advanced cirrhosis livers, which likely facilitated the malignant progression of ALD. Key points This study provides single‐cell landscape of human liver samples across different ALD stages. The ALB+ KRT7+ epithelium were enriched in ALD patients, and the function of this epithelial population varied significantly across ALD stages. ALB+KRT7+ epithelium from advanced alcohol‐related cirrhosis had malignant transformation potential and tumour promotion activity. The comprehensive changes of parenchymal and nonparenchymal cells in the ALD livers lay a hidden danger for the further malignant progression.

Abstract The pursuit of room‐temperature superconductivity at an accessible synthetic pressure has been a long‐held dream for both theoretical and experimental physicists. Recently, a controversial report by Dasenbrock‐Gammon et al. claims that the nitrogen‐doped lutetium trihydride exhibits room‐temperature superconductivity at near‐ambient pressure. However, many researchers have failed to independently reproduce these results, which has sparked intense skepticism on this report. In this work, a LuH2±xNy sample is fabricated using high‐pressure and high‐temperature methods. The composition and structural characterization are the same as the aforementioned near‐ambient superconductor. In situ X‐ray diffraction investigations indicate that a high‐pressure phase transition toward Fm3¯m‐LuH3±xNy occurred in the sample at 59 GPa. The temperature‐dependent resistance measurements reveal that two possible superconductivity transition are observed at 95 GPa, with Tc1 ≈6.5 K for high‐Tc phase and Tc2 ≈2.1 K for low‐Tc phase, arising from the disparate phases in the sample. Resistivity measurements in the Fm3¯m‐LuH3±xNy phase under varying magnetic fields exhibited characteristics consistent with superconductivity, with an upper critical field μ0Hc2(0) of 3.3 T measured at 163 GPa. This work is expected to shed some light on the controversy surrounding superconductivity in the nitrogen‐doped lutetium hydride system.

Compared to conventional materials, underwater metamaterials possess numerous advantages in the manipulation of sound waves, which have garnered increasing attention. In terms of composition, commonly studied underwater wideband metamaterials can be classified into solid-phase pentamode metafluid and water–solid coupling metafluid. The concept of multiphase design in pentamode metafluid allows for decoupling the regulation of equivalent density from that of the equivalent bulk modulus, facilitating more convenient structural design. In typical auxetic metamaterial structure designs, the “re-entrant” mechanism is commonly employed; the skeleton is inwardly bent to a certain extent, enabling the design of a low volume-modulus for each cell. Consequently, a novel type of water–solid coupling metafluid is devised by combining the concepts of “multiphase” and “re-entrant”. Firstly, a straight-sided skeleton (referred to as “ss” skeletal) unit cell is designed, and its compression wave frequency band is determined through analysis of its band characteristics and related vibration modes. Subsequently, the “re-entrant” (referred to as “re”) mechanism is introduced into a unit cell, revealing an increase in equivalent density while decreasing the equivalent volume modulus due to this feature. The bent skeleton provides lower bulk modulus, while multiphase (referred to as “mp”) counterweighting offers higher equivalent density; their combination enables designing more impedance-matched metafluid. Then, a unit cell is designed utilizing both “re” and “mp” characteristics. Finally, acoustic performance simulations and analyses verify that both types exhibit excellent broadband water-like properties within the frequency range of 5000–27,000 Hz. In order to further validate the reliability of the design concept, two pairs of underwater metafluid cells with an impedance-matching effect were subsequently developed, demonstrating sound speeds that are half and one-third that of water, respectively. The skeleton thickness of the “re” cell was moderately enhanced compared to that of the straight side cell, thereby presenting an innovative approach for designing robust underwater metafluid cells.

To understand the occurrence characteristics of microplastics in the soil of the Xinxiang section of the Weihe River Basin, the soil samples of different soil types and different soil layers were collected, soil microplastics were identified using the Agilent 8700 laser direct infrared （LDIR） chemical imaging system, and the ecological risks of soil microplastics were assessed using the polymer risk index （ H ） and pollution load index （PLI）. The results showed that the proportions of polyurethane （PU） and polyethylene （PE） were 17.57% and 15.97%, respectively, in the soil of the Xinxiang section of Weihe River Basin； the particle diameter of microplastics mainly ranged from 20 to 100 μm, and the proportions of 20 to 50 μm and 50 to 100 μm were 76.17% and 15.56%, respectively； and the average abundance of microplastics was （4 629±683） n·kg -1 . Significant differences exist in soil microplastic type （ P <0.001） and microplastic abundance at different soil depths （ P <0.05）. The microplastic particle diameter （ P <0.05） at each sampling site and the microplastic abundance at each sampling site decreased with the increase in soil depth. The abundance of PU and PE at sampling sites S7 and S3 was 1 587 n·kg -1 and 960 n·kg -1 , respectively. The ecological risk of soil microplastics at each sampling site decreased with the increase in soil depth； the ecological risk of soil microplastics at sampling site S7 was at high risk, sampling site S6 was at low risk, and other sampling sites were at medium risk.