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2. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, Cadrin-Tourigny, Julia, Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, and Cadrin-Tourigny, Julia

Published
2024

3. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., Cadrin-Tourigny, Julia, Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., and Cadrin-Tourigny, Julia

Abstract

Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC.Methods This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America. Patients were classified according to whether they received treatment in North America or Europe and were further stratified by baseline predicted VA risk into low- (<10%/5 years), intermediate- (10%-25%/5 years), and high-risk (>25%/5 years) groups. Differences in ICD implantation and survival free from sustained VA events (including appropriate ICD therapy) were assessed.Results One thousand ninety-eight patients were followed for a median of 5.1 years; 554 (50.5%) received a primary prevention ICD, and 286 (26.0%) experienced a first VA event. After adjusting for baseline risk factors, North Americans were more than three times as likely to receive ICDs {hazard ratio (HR) 3.1 [95% confidence interval (CI) 2.5, 3.8]} but had only mildly increased risk for incident sustained VA [HR 1.4 (95% CI 1.1, 1.8)]. North Americans without ICDs were at higher risk for incident sustained VA [HR 2.1 (95% CI 1.3, 3.4)] than Europeans.Conclusions North American ARVC patients were substantially more likely than Europeans to receive primary prevention ICDs across all arrhythmic risk strata. A lower rate of ICD implantation in Europe was not associated with a higher rate of VA events in those without ICDs., Funding Agencies|Leonie-Wild Foundation; Leyla Erkan Family Fund for ARVD Research; Hugh Calkins, Marvin H. Weiner, and Jacqueline J. Bernstein Cardiac Arrhythmia Center; Dr Francis P. Chiaramonte Private Foundation; Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins; Bogle Foundation; Campanella Family; Patrick J. Harrison Family; Peter French Memorial Foundation; ALF foundation; Wilmerding Endowments; NIH [T32HL007227]; NIH Loan Repayment Program [L30HL165535]; Philippa and Marvin Carsley Cardiology Research Chair; Montreal Heart Institute Foundation; Norwegian Research Council [309762, 288438, 298736]; ZonMW Off Road personal research grant; Dutch Heart Association; Netherlands Cardiovascular Research Initiative - Dutch Heart Foundation [2018-30 PREDICT2]; Dutch Heart Foundation; Netherlands Heart Institute [06901]; Georg and Bertha Schwyzer-Winiker Foundation; Baugarten Foundation; Swiss National Science Foundation; Swiss Heart Foundation; USZ Foundation; Daniel Bravo Foundation; Spanish Society of Cardiology; Sociedad Espanola de Cardiologia; Swedish Heart Lung Foundation

Published
2024
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4. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Carrick, Richard T, primary, De Marco, Corrado, additional, Gasperetti, Alessio, additional, Bosman, Laurens P, additional, Gourraud, Jean-Baptiste, additional, Trancuccio, Alessandro, additional, Mazzanti, Andrea, additional, Murray, Brittney, additional, Pendleton, Catherine, additional, Tichnell, Crystal, additional, Tandri, Harikrishna, additional, Zeppenfeld, Katja, additional, Wilde, Arthur A M, additional, Davies, Brianna, additional, Seifer, Colette, additional, Roberts, Jason D, additional, Healey, Jeff S, additional, MacIntyre, Ciorsti, additional, Alqarawi, Wael, additional, Tadros, Rafik, additional, Cutler, Michael J, additional, Targetti, Mattia, additional, Calò, Leonardo, additional, Vitali, Francesco, additional, Bertini, Matteo, additional, Compagnucci, Paolo, additional, Casella, Michela, additional, Dello Russo, Antonio, additional, Cappelletto, Chiara, additional, De Luca, Antonio, additional, Stolfo, Davide, additional, Duru, Firat, additional, Jensen, Henrik K, additional, Svensson, Anneli, additional, Dahlberg, Pia, additional, Hasselberg, Nina E, additional, Di Marco, Andrea, additional, Jordà, Paloma, additional, Arbelo, Elena, additional, Moreno Weidmann, Zoraida, additional, Borowiec, Karolina, additional, Delinière, Antoine, additional, Biernacka, Elżbieta K, additional, van Tintelen, J Peter, additional, Platonov, Pyotr G, additional, Olivotto, Iacopo, additional, Saguner, Ardan M, additional, Haugaa, Kristina H, additional, Cox, Moniek, additional, Tondo, Claudio, additional, Merlo, Marco, additional, Krahn, Andrew D, additional, te Riele, Anneline S J M, additional, Wu, Katherine C, additional, Calkins, Hugh, additional, James, Cynthia A, additional, and Cadrin-Tourigny, Julia, additional

Published
2024
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