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Competing Interests: Disclosure statement Supported by the American Partnership for Eosinophilic Disorders and American Academy of Allergy, Asthma, and Immunology HOPE (grant to D.A.H.); the American Partnership for Eosinophilic Disorders Pilot Grant (grant to D.A.H.); the Food Allergy Fund (to D.A.H.); The Hartwell Foundation Individual Biomedical Award (to D.A.H.); the American Academy of Allergy, Asthma & Immunology Faculty Development Award (to D.A.H.); institutional development funds from the Children’s Hospital of Philadelphia (to D.A.H.); funds from Ira and Diana Riklis and Andrew and Talia Day (to J.M.S.); the Yehudai Family Foundation (to J.M.S.). Food Allergy Science Initiative (to W.G.S.); institutional development funds from the Children’s Hospital of Philadelphia to the Center for Applied Genomics (to H.H.); and the Children’s Hospital of Philadelphia Endowed Chair in Genomic Research (to H.H.). Disclosure of potential conflict of interest: J. Dilollo, J. M. Spergel, and D. A. Hill hold a patent on the use of functional T-cell assays for the identification of EoE-causal foods. The rest of the authors declare that they have no relevant conflicts of interest.