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In the context of organizers’ behavior scheduling optimization, accurately assessing and optimizing scheduling programs is essential. This paper introduces HyperFusion, a framework designed to enhance scheduling efficiency through hypergraph learning techniques and an adaptive feature fusion model tailored to organizers’ behavioral patterns. The model categorizes and evaluates scheduling methods by identifying peer groups of organizers who share similar behavioral and operational attributes. Addressing challenges such as variability in scheduling approaches across different environments and the availability of diverse behavioral data, HyperFusion utilizes hypergraph-based feature fusion to identify high-quality scheduling and behavioral features that reflect each organizer’s unique scheduling style and operational impact. Employing a probabilistic model, the framework represents each organizer’s attributes in a latent space, enabling a nuanced understanding of their contributions. A large-scale hypergraph is constructed to map relationships and similarities among organizers, identifying dense subgraphs or “circles” of organizers with shared attributes. By mining these high-order relationships within these “organizer circles”, HyperFusion enhances scheduling quality and provides adaptive fusion of behavioral features, optimizing the scheduling process to meet the objectives of high-order relationship discovery. Experiments conducted on a dataset of organizers from 36 prominent institutions (our complied data set) demonstrate the model’s effectiveness in improving scheduling programs, underscoring its capability to align scheduling practices with adaptive, data-driven optimization and fostering a responsive and efficient scheduling system.

Objective: This study aimed to explore the mitigating effects of germinated foxtail millet bioactive peptides (GRBPs) on copper-induced oxidative damage in Caenorhabditis elegans (C. elegans) and its potential mechanisms. Methods: By randomly grouping, the wild-type N2 C. elegans were divided into a control group and GRBPs groups to examine the effects of GRBPs feeding on mobility and survival rate of C. elegans induced by copper. The impact of GRBPs on oxidative damage was assessed by measuring the levels of reactive oxygen species (ROS), glutathione (GSH), and the activities of catalase (CAT), and superoxide dismutase (SOD). Furthermore, the mechanism of action of GRBPs was explored through genomic and transcriptomic sequencing techniques (RNA-seq) and untargeted metabolomics analysis. Antioxidant-related genes were validated by reverse transcription and real-time quantitative PCR (qPCR). Results: GRBPs obviously improved the survival rate and mobility of C. elegans after copper treatment, and a concentration of 1 mg/mL of GRBPs extremely significantly reduced the levels of MDA (P