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Depending on the design, the connections of precast concrete (PC) structures can be susceptible to severe damage under large deformation. Consequently, PC structures may behave differently from cast-in-situ reinforced concrete (RC) structures under column loss scenarios. This study focuses on a class of PC structures that utilize splice sleeves (SSs) to assemble the precast components with integrated beam-column connections (IBCCs). This PC design can alleviate rebar congestion issues and minimize the need for post-cast concrete in the connection regions during assembly. The IBCCs are typically designed to mimic the behavior of corresponding RC connections under service loading conditions. However, the extent of structural emulation under column loss scenarios is not immediately clear. In this paper, the collapse behavior of PC structures with IBCCs under an internal column removal scenario is thoroughly assessed using experimental investigations and numerical analyses. Three PC subassemblages and one RC subassemblage are tested experimentally to provide experimental data for the calibration and validation of finite element (FE) models. The collapse behavior of full-span PC and RC subassemblages are next compared numerically under the internal column loss scenario, with an accompanying investigation on the influence of horizontal SSs. It is found that the PC subassemblages exhibit emulative collapse behavior as the RC subassemblage under internal column loss scenarios, provided that the horizontal SSs are located beyond the beam plastic region under the internal column loss scenario. To achieve the latter, a minimum distance of 0.15 L (L is clear beam span before column removal) is recommended for the positioning of horizontal SSs under the internal column loss scenario. Finally, it is shown that the fracture load and corresponding displacement can be enhanced with the incorporation of high ductility rebars. • A comprehensive investigation on the failure response of precast reinforced concrete structures with integrated beam-column connections (IBCC) under column loss. • Compare and contrast the performance of said precast concrete connections against monolithic concrete connections. • The influence of splice sleeve locations is elaborated. [ABSTRACT FROM AUTHOR]

Multiple hereditary infundibulocystic basal cell carcinoma syndrome (MHIBCC), an autosomal dominant disorder caused by variants in SUFU, is characterized by numerous infundibulocystic basal cell carcinomas (IBCCs). In this report, we present a possible case of mosaic MHIBCC. A 57‐year‐old woman underwent the removal of four papules on her face, which were diagnosed as IBCCs. Exome sequencing revealed a SUFU c.1022+1G>A mutation within the skin tumor. The same mutation was detected in her blood but at a lower allele frequency. TA cloning revealed that the allele frequency of the mutation in the blood was 0.07. Additionally, tumor assessment revealed loss of heterozygosity (LOH) in chromosome 10, including the SUFU locus. These results indicate the patient had mosaicism for the SUFU mutation in normal tissues, aligning with the mosaic MHIBCC diagnosis. This, combined with LOH, likely contributed to IBCC development. Mosaic MHIBCC may present with milder symptoms. However, it may still increase the risk of developing brain tumors and more aggressive basal cell carcinoma. The possibility of mosaicism should be investigated in mild MHIBCC cases, where standard genetic tests fail to detect SUFU germline variants. [ABSTRACT FROM AUTHOR]