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The present work deals with the synthesis of a novel Fe40Mn20Cr20Ti10Al10 high-entropy alloy (HEA) by mechanical alloying (MA) and spark plasma sintering (SPS). The mechanically alloyed HEA exhibits a dual-phase structure consisting of BCC (a = 0.287 nm; cI2) and χ-phase (a = 0.889 nm; cI58). The 40-h milled alloy was thermally stable up to 400 °C (673 K). The as-milled alloy showed the formation of FCC solid solution around 510 °C. This finding was confirmed by the DSC and ex situ XRD of various heat-treated samples. The consolidation of milled powder led to the formation of FCC phase along with retained BCC phase (major) and nanoprecipitates of χ-phase. The hardness, elastic modulus, and compressive yield stress in the SPSed samples were ~ 6.4 ± 0.2 GPa, 184 ± 5 GPa, and ~ 1900 ± 200 MPa, respectively. The SPSed sample showed appreciable failure strain under compression of ~ 6.7%. The excellent mechanical properties in the SPSed sample may be attributed to the formation of dual phase and strengthening mostly due to grain boundary, dislocation, and precipitation. This dual-phase Fe-enriched HEA seems to have great potential in high-temperature structural applications. [ABSTRACT FROM AUTHOR]

The article presents a 2025 case report of a 28-year-old pregnant woman with systemic lupus erythematosus (SLE) with lupus nephritis and secondary obstetric antiphospholipid antibody syndrome. She was managed with HCQ and azathioprine, with the latter being stopped after she had diffuse hair loss and oral ulcers, and was started on tab ciclosporine for its efficacy and safety for SLE management during pregnancy, plus supplementations. The patient gradually recovered in the next two weeks.

Monogenic lupus is a rare variant of systemic lupus erythematosus (SLE) that develops in patients with a single gene disorder. Early complement component deficiencies were the first forms of monogenic lupus to be described, and C1Q gene mutations are one of the most common forms. C1QA complement deficiency has been reported to occur usually due to biallelic variants in C1QA gene, and compound heterozygous variants in C1QA gene have rarely been reported. A majority of monogenic lupus patients with C1Q deficiency present with mucocutaneous, renal, and musculoskeletal manifestations. Our patient is an unusual case of monogenic lupus with severe neurological manifestations along with cutaneous, haematological, and hepatic manifestations secondary to rare compound heterozygous variants in C1QA gene and antiribosomal P autoantibody positivity. She was treated with glucocorticoids, rituximab, and fresh frozen plasma with partial neurological recovery. Thus, we present a unique case of monogenic lupus due to a rare compound heterozygous variant in C1QA gene with a brief review of literature., (© Japan College of Rheumatology 2024. Published by Oxford University Press.)