40 results on '"Jesús, S."'
Search Results
2. Mutations in the tail and rod domains of the neurofilament heavy‐chain gene increase the risk of ALS
- Author
-
Heather Marriott, Thomas P. Spargo, Ahmad Al Khleifat, Peter M Andersen, Nazli A. Başak, Johnathan Cooper‐Knock, Philippe Corcia, Philippe Couratier, Mamede deCarvalho, Vivian Drory, Marc Gotkine, John E. Landers, Russell McLaughlin, Jesús S. Mora Pardina, Karen E. Morrison, Susana Pinto, Christopher E. Shaw, Pamela J. Shaw, Vincenzo Silani, Nicola Ticozzi, Philip vanDamme, Leonard H. van denBerg, Patrick Vourc'h, Markus Weber, Jan H. Veldink, Project MinE ALS Sequencing Consortium, Richard J. Dobson, Patrick Schwab, Ammar Al‐Chalabi, and Alfredo Iacoangeli
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective Neurofilament heavy‐chain gene (NEFH) variants are associated with multiple neurodegenerative diseases, however, their relationship with ALS has not been robustly explored. Still, NEFH is commonly included in genetic screening panels worldwide. We therefore aimed to determine if NEFH variants modify ALS risk. Methods Genetic data of 11,130 people with ALS and 7,416 controls from the literature and Project MinE were analysed. We performed meta‐analyses of published case–control studies reporting NEFH variants, and variant analysis of NEFH in Project MinE whole‐genome sequencing data. Results Fixed‐effects meta‐analysis found that rare (MAF
- Published
- 2024
- Full Text
- View/download PDF
3. Gradual change and mosaic pattern of macrofaunal assemblages along depth and sediment gradients in a tropical oceanic island
- Author
-
Jeffrey A. Sibaja-Cordero and Jesús S. Troncoso
- Subjects
Biology (General) ,QH301-705.5 - Abstract
The ecology of macrofauna on the sandy bottom of oceanic islands in the tropics has rarely been studied. The present study was conducted at Isla del Coco, Costa Rica, a tropical oceanic island, to determine how the soft-bottom macrofauna assemblages vary along different levels of ocean exposure and their associated environmental conditions. The macrofauna was collected from five grabs at each of the 27 stations (between 3 and 75 m deep) in April 2010. The broad-scale pattern consists of a gradual increase in the complexity of assemblages (taxonomical or feeding guilds in the sediment) from the inner part to the outside of the bays. The leading determinant of this pattern was the interplay between ocean exposure and sediment variation with depth that produces habitat heterogeneity. The main taxa responsible for differences between ocean exposure zones were the polychaetes Westheidesyllis heterocirrata and Magelona californica, the filter-feeding bivalve Gouldia californica, and the predatory isopod Eurydice caudata. Coarse bottoms had more mobile predators and suspension feeders, whereas passive suspension feeders or subsurface deposit feeders dominated fine sands. The deeper stations were dominated by organisms feeding actively on particles from the water or on the sediment surface. Moreover, more feeding guilds were found in deeper waters. Additionally, at the small-scale view (grabs within each station), macrofauna composition evidences a mosaic pattern, mainly at the inner and middle of the bays, caused by biological or environmental disturbances.
- Published
- 2024
- Full Text
- View/download PDF
4. Classification performance assessment for imbalanced multiclass data
- Author
-
Jesús S. Aguilar-Ruiz and Marcin Michalak
- Subjects
Medicine ,Science - Abstract
Abstract The evaluation of diagnostic systems is pivotal for ensuring the deployment of high-quality solutions, especially given the pronounced context-sensitivity of certain systems, particularly in fields such as biomedicine. Of notable importance are predictive models where the target variable can encompass multiple values (multiclass), especially when these classes exhibit substantial frequency disparities (imbalance). In this study, we introduce the Imbalanced Multiclass Classification Performance (IMCP) curve, specifically designed for multiclass datasets (unlike the ROC curve), and characterized by its resilience to class distribution variations (in contrast to accuracy or F $$_\beta$$ β -score). Moreover, the IMCP curve facilitates individual performance assessment for each class within the diagnostic system, shedding light on the confidence associated with each prediction—an aspect of particular significance in medical diagnosis. Empirical experiments conducted with real-world data in a multiclass context (involving 35 types of tumors) featuring a high level of imbalance demonstrate that both the IMCP curve and the area under the IMCP curve serve as excellent indicators of classification quality.
- Published
- 2024
- Full Text
- View/download PDF
5. Post-fire vegetation dynamics of a temperate mixed forest: An assessment based on the variability of Landsat spectral indices
- Author
-
Jesús S. Ibarra-Bonilla, Alfredo Pinedo-Alvarez, Jesús A. Prieto-Amparán, Pablo Siller-Clavel, Eduardo Santellano-Estrada, Alan Álvarez-Holguín, and Federico Villarreal-Guerrero
- Subjects
Wildfire ,Remote sensing ,NDVI ,SAVI ,Burned area ,Topography ,Forestry ,SD1-669.5 ,Plant ecology ,QK900-989 - Abstract
Fire plays a critical role in nutrient cycling and species diversity but also causes severe disturbances to ecosystems. Despite remote sensing has emerged as a valuable tool to study wildfires, a lack of information regarding post-fire dynamics still remains for certain regions. This study investigated the post-fire dynamics of four burned sites in the temperate forest of Chihuahua, northern Mexico from 2009 to 2017, based on the variability of spectral indices under varied topographic conditions of aspects and slopes. The Normalized Difference Vegetation index (NDVI), Soil Adjusted Vegetation Index (SAVI), Normalized Burn Ratio (NBR), and Normalized Difference Water index (NDWI) were utilized to assess vegetation recovery on the burned sites. One-way ANOVAs and Tukey´s tests were performed to evaluate separately the effects of aspect and slope on the indices’ variability (p < 0.05). In general, the NDVI measured the highest values of the burned sites along the evaluated lapse while the NDWI indicated the lowest measures. Results indicated significant effects of aspect on NDVI and SAVI (p < 0.05), while slope significantly influenced the four evaluated indices (p < 0.05).That in turn showed northern aspects and steeper slopes to have the highest post-fire vegetation recoveries. Furthermore, aspect only affected the bi-annual variability of SAVI (p < 0.05). However, the NBR and NDWI showed higher magnitudes of change among periods than the SAVI (i. e., recovery and non-recovery). Besides registering a continuous recovery of the burned sites from the wildfire events to 2015, this study revealed the NDVI and SAVI as the most useful spectral indices for assessing post-fire vegetation dynamics in the region. Besides aspect and slope, future studies could focus on the inclusion of additional indicators to more effectively assess post-fire ecosystem dynamics in northern Mexico.
- Published
- 2024
- Full Text
- View/download PDF
6. Random Neural Network Ensemble for Very High Dimensional Datasets.
- Author
-
Jesús S. Aguilar-Ruiz and Matteo Fratini
- Published
- 2024
- Full Text
- View/download PDF
7. Environmental influence on the functional ecological structure of benthic macrofaunal communities of the northwest Iberian coast
- Author
-
Alves, Catarina M., Gomes, Marisa A., Troncoso, Jesus S., and Gomes, Pedro T.
- Published
- 2024
- Full Text
- View/download PDF
8. Post-fire vegetation dynamics of a temperate mixed forest: An assessment based on the variability of Landsat spectral indices
- Author
-
Ibarra-Bonilla, Jesús S., Pinedo-Alvarez, Alfredo, Prieto-Amparán, Jesús A., Siller-Clavel, Pablo, Santellano-Estrada, Eduardo, Álvarez-Holguín, Alan, and Villarreal-Guerrero, Federico
- Published
- 2024
- Full Text
- View/download PDF
9. Morphological and molecular characterization of Stomachicola muraenesocis Yamaguti, 1934 (Digenea: Hemiuridae) from the daggertooth pike conger Muraenesox cinereus (Forsskål)
- Author
-
Reza Ghanei-Motlagh, Jesús S. Hernández-Orts, Mark D. Fast, Shona K. Whyte, Mansour El-Matbouli, and Mona Saleh
- Subjects
Dinurinae ,Hemiuroidea ,Lecithasteridae ,molecular characterization ,morphological variation ,rDNA sequence ,18S ,28S ,taxonomic revision ,trematode ,Biochemistry ,QD415-436 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Hemiurid digeneans conspecific with Stomachicola muraenesocis Yamaguti, 1934 (the type species of the genus Stomachicola Yamaguti, 1934) were collected from the stomach of the daggertooth pike conger Muraenesox cinereus (Forsskål) off the Persian Gulf of Iran. This study aimed to provide a detailed characterization of Stom. muraenesocis, including measurements, illustrations and scanning electron microscopy (s.e.m.) representations. Comparisons with the original and previous descriptions revealed morphological and metrical variations in several features (i.e. body size and shape, arrangement of reproductive organs, soma to ecsoma length ratio, position of genital opening, number of vitelline tubules and extension of uterine coils) between Stom. muraenesocis from different hosts and localities. This study presents the first molecular sequence data associated with the small (18S) and large (28S) subunit nuclear ribosomal RNA genes (rDNA) for Stom. muraenesocis. Phylogenetic analyses of the 18S dataset placed Stom. muraenesocis as sister lineage to a clade formed of a group of species of Lecithaster Lühe, 1901 (Lecithasteridae Odhner, 1905). In contrast, phylogenetic analyses based on the 28S consistently recovered a sister relationship between Stom. muraenesocis and representatives of the Hemiuridae Looss, 1899. Further comprehensive phylogenetically based classification in light of morphology and taxonomic history of the Hemiuridae and Lecithasteridae is required to infer phylogenetic affinities and historical biogeography of Stomachicola. A comprehensive list of previously reported species of Stomachicola together with their associated hosts, localities and morphometric data is provided.
- Published
- 2024
- Full Text
- View/download PDF
10. Caracterización clínico-epidemiológica de los pacientes con COVID persistente en México
- Author
-
Luis Del Carpio-Orantes, Daniela Trelles-Hernández, Sergio García-Méndez, Jesús S. Sánchez-Díaz, Andrés Aguilar-Silva, and Ener R. López-Vargas
- Subjects
COVID persistente. Disautonomías. Fatiga. ,Public aspects of medicine ,RA1-1270 ,Internal medicine ,RC31-1245 - Abstract
Antecedentes: El COVID persistente se define como la persistencia de síntomas de COVID-19 después de cuatro semanas de cursar con un cuadro agudo, según la definición más reciente de los Centers for Disease Control and Prevention. Se estima que existen 65 millones de personas afectadas por esta entidad, aunque algunos reportes indican 200 millones. Objetivo: Caracterizar a la población afectada por COVID persistente en México. Material y métodos: Se incluyeron pacientes mayores de 18 años que consintieron responder a una encuesta en línea y que cumplían los criterios de COVID persistente. Resultados: Se incluyeron los datos de 203 sujetos. Se identificó que 138 (68.0 %) contestaron ser del sexo femenino, con una media de edad de 41.8 años; 29.6 % presentó enfermedad grave y 70.4 %, enfermedad leve a moderada; 89.7 % había recibido vacunas previas para COVID-19: 6.9 %, una dosis; 31.5 %, dos dosis; y 51.2 %, tres o más dosis. Los principales factores de riesgo fueron diabetes, sobrepeso u obesidad e hipertensión arterial sistémica. El principal síntoma reportado fue fatiga, seguido de otras manifestaciones neuropsiquiátricas. Conclusión: Es importante caracterizar a la población para generar protocolos de diagnóstico y tratamiento.
- Published
- 2024
- Full Text
- View/download PDF
11. Helminth fauna of the black goby Gobius niger L. (Gobiiformes: Gobiidae) from the Finnish Archipelago, Baltic Sea: Molecular and morphological data
- Author
-
Martinek, Inga and Hernández-Orts, Jesús S.
- Published
- 2024
- Full Text
- View/download PDF
12. The association between climate and emergency department visits for renal and urinary disease in Charlottesville, Virginia
- Author
-
Neyra, Jesus S. and Davis, Robert E.
- Published
- 2024
- Full Text
- View/download PDF
13. Helminth fauna of the black goby Gobius niger L. (Gobiiformes: Gobiidae) from the Finnish Archipelago, Baltic Sea: Molecular and morphological data
- Author
-
Inga Martinek and Jesús S. Hernández-Orts
- Subjects
Helminths ,Molecules and morphology ,Gobius niger ,Diversity ,Baltic sea ,Life-cycles ,Infectious and parasitic diseases ,RC109-216 - Abstract
Black gobies (Gobius niger) from the Finnish Archipelago, Baltic Sea, were screened for helminth infections in summer 2020. Helminths were identified morphologically and/or molecularly. Altogether 26 novel sequences were generated and analysed using maximum likelihood estimation. Morphological and phylogenetic analyses based on mitochondrial genes revealed the presence of 8 species belonging to the Digenea (Diplostomum mergi Lineage 3), Cestoda (Bothriocephalus scorpii), Nematoda (Contracaecum rudolphii A, Cucullanus sp. and Hysterothylacium aduncum), and Acanthocephala (a putative new species of Corynosoma, Corynosoma semerme and Neoechinorhynchus sp.). Phylogenetic and comparative sequence analyses revealed that the putative new acanthocephalan species is closely related to C. neostrumosum described from the Caspian seal, Pusa caspica, in the Caspian Sea. The black goby represents a new host record for four parasite species (Diplostomum mergi Lineage 3, Contracaecum rudolphii A, Corynosoma semerme and Corynosoma sp.). The Finnish Archipelago is a novel locality record for three species (Corynosoma sp., Diplostomum mergi Lineage 3 and Bothriocephalus scorpii).
- Published
- 2024
- Full Text
- View/download PDF
14. Surface plasmon resonance microscopy identifies glycan heterogeneity in pancreatic cancer cells that influences mucin-4 binding interactions.
- Author
-
Jesús S Aguilar Díaz de León, Miyuki Thirumurty, and Nguyen Ly
- Subjects
Medicine ,Science - Abstract
Membrane proteins are the main targets of therapeutic drugs and most of them are glycosylated. Glycans play pivotal roles in several biological processes, and glycosylation changes are a well-established hallmark of several types of cancer, including pancreatic cancer, that contribute to tumor growth. Mucin-4 (MUC-4) is a membrane glycoprotein which is associated with pancreatic cancer and metastasis, and it has been targeted as a promising vaccine candidate. In this study, Surface Plasmon Resonance Microscopy (SPRM) was implemented to study complex influences of the native N-glycan cellular environment on binding interactions to the MUC-4 receptor as this is currently the only commercially available label-free technique with high enough sensitivity and resolution to measure binding kinetics and heterogeneity on single cells. Such unique capability enables for a more accurate understanding of the "true" binding interactions on human cancer cells without disrupting the native environment of the target MUC-4 receptor. Removal of N-linked glycans in pancreatic cancer cells using PNGase F exposed heterogeneity in Concanavalin (Con A) binding by revealing three new binding populations with higher affinities than the glycosylated control cells. Anti-MUC-4 binding interactions of enzymatically N-linked deglycosylated pancreatic cancer cells produced a 25x faster association and 37x higher affinity relative to the glycosylated control cells. Lastly, four interaction modes were observed for Helix Pomatia Agglutinin (HPA) binding to the glycosylated control cells, but shifted and increased in activity upon removal of N-linked glycans. These results identified predominant interaction modes of glycan and MUC-4 in pancreatic cancer cells, the kinetics of their binding interactions were quantified, and the influence of N-linked glycans in MUC-4 binding interactions was revealed.
- Published
- 2024
- Full Text
- View/download PDF
15. Caracterización clínico-epidemiológica de los pacientes con COVID persistente en México
- Author
-
Del Carpio-Orantes, Luis, primary, Trelles-Hernández, Daniela, additional, García-Méndez, Sergio, additional, Sánchez-Díaz, Jesús S., additional, Aguilar-Silva, Andrés, additional, and López-Vargas, Ener R., additional
- Published
- 2024
- Full Text
- View/download PDF
16. Morphological and molecular data on helminths of Didelphis virginiana and Philander vossi (Mammalia: Didelphidae) from the Yucatán Peninsula, southeast Mexico
- Author
-
PANTI-MAY, JESÚS ALONSO, primary, CHAN-CASANOVA, ANYELA JACKELIN, additional, CANCHE-POOL, ELSY, additional, TELLO-MARTÍN, RAÚL, additional, RUIZ-PIÑA, HUGO, additional, CONCHA-GUILLERMO, HENRY, additional, RETANA-GUIASCÓN, OSCAR, additional, VEGA, PEDRO PABLO MARTÍNEZ, additional, CHABLÉ-SANTOS, JUAN, additional, ESTRELLA-MARTÍNEZ, ERENDIRA, additional, MOGUEL-CHIN, WILSON ISAIAS, additional, HERNÁNDEZ-ORTS, JESÚS S., additional, HERNÁNDEZ-MENA, DAVID I., additional, MENDOZA-GARFIAS, BERENIT, additional, and GARCÍA-PRIETO, LUIS, additional
- Published
- 2024
- Full Text
- View/download PDF
17. Race Dynamics in Triathlon Mixed-Team-Relay Meaningfully Changes with The New Regulation Towards Paris 2024
- Author
-
Martínez-Sobrino, Jesús, primary, Del Cerro, Jesús S., additional, González-Ravé, José M., additional, and Veiga, Santiago, additional
- Published
- 2024
- Full Text
- View/download PDF
18. Surface plasmon resonance microscopy identifies glycan heterogeneity in pancreatic cancer cells that influences mucin-4 binding interactions
- Author
-
Aguilar Díaz de león, Jesús S., primary, Thirumurty, Miyuki, additional, and Ly, Nguyen, additional
- Published
- 2024
- Full Text
- View/download PDF
19. Classification performance assessment for imbalanced multiclass data
- Author
-
Aguilar-Ruiz, Jesús S., primary and Michalak, Marcin, additional
- Published
- 2024
- Full Text
- View/download PDF
20. Integral Transform Solution for Natural Convection Within Horizontal Concentric Annular Cavities
- Author
-
Pereira, Luiz M., primary, Quaresma, João N. N., additional, Pérez Guerrero, Jesús S., additional, and Cotta, Renato M., additional
- Published
- 2024
- Full Text
- View/download PDF
21. Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS
- Author
-
Marriott, Heather, Spargo, Thomas P., Al Khleifat, Ahmad, Andersen, Peter M., Başak, Nazli A., Cooper-Knock, Johnathan, Corcia, Philippe, Couratier, Philippe, de Carvalho, Mamede, Drory, Vivian, Gotkine, Marc, Landers, John E., McLaughlin, Russell, Pardina, Jesús S. Mora, Morrison, Karen E., Pinto, Susana, Shaw, Christopher E., Shaw, Pamela J., Silani, Vincenzo, Ticozzi, Nicola, van Damme, Philip, van den Berg, Leonard H., Vourc'h, Patrick, Weber, Markus, Veldink, Jan H., Dobson, Richard J., Schwab, Patrick, Al-Chalabi, Ammar, Iacoangeli, Alfredo, Marriott, Heather, Spargo, Thomas P., Al Khleifat, Ahmad, Andersen, Peter M., Başak, Nazli A., Cooper-Knock, Johnathan, Corcia, Philippe, Couratier, Philippe, de Carvalho, Mamede, Drory, Vivian, Gotkine, Marc, Landers, John E., McLaughlin, Russell, Pardina, Jesús S. Mora, Morrison, Karen E., Pinto, Susana, Shaw, Christopher E., Shaw, Pamela J., Silani, Vincenzo, Ticozzi, Nicola, van Damme, Philip, van den Berg, Leonard H., Vourc'h, Patrick, Weber, Markus, Veldink, Jan H., Dobson, Richard J., Schwab, Patrick, Al-Chalabi, Ammar, and Iacoangeli, Alfredo
- Abstract
Objective: Neurofilament heavy-chain gene (NEFH) variants are associated with multiple neurodegenerative diseases, however, their relationship with ALS has not been robustly explored. Still, NEFH is commonly included in genetic screening panels worldwide. We therefore aimed to determine if NEFH variants modify ALS risk. Methods: Genetic data of 11,130 people with ALS and 7,416 controls from the literature and Project MinE were analysed. We performed meta-analyses of published case–control studies reporting NEFH variants, and variant analysis of NEFH in Project MinE whole-genome sequencing data. Results: Fixed-effects meta-analysis found that rare (MAF <1%) missense variants in the tail domain of NEFH increase ALS risk (OR 4.55, 95% CI 2.13–9.71, p < 0.0001). In Project MinE, ultrarare NEFH variants increased ALS risk (OR 1.37 95% CI 1.14–1.63, p = 0.0007), with rod domain variants (mostly intronic) appearing to drive the association (OR 1.45 95% CI 1.18–1.77, pMadsen–Browning = 0.0007, pSKAT-O = 0.003). While in the tail domain, ultrarare (MAF <0.1%) pathogenic missense variants were also associated with higher risk of ALS (OR 1.94, 95% CI 0.86–4.37, pMadsen–Browning = 0.039), supporting the meta-analysis results. Finally, several tail in-frame deletions were also found to affect disease risk, however, both protective and pathogenic deletions were found in this domain, highlighting an intricated architecture that requires further investigation. Interpretation: We showed that NEFH tail missense and in-frame deletion variants, and intronic rod variants are risk factors for ALS. However, they are not variants of large effect, and their functional impact needs to be clarified in further studies. Therefore, their inclusion in routine genetic screening panels should be reconsidered.
- Published
- 2024
- Full Text
- View/download PDF
22. Elucidating Structural Stability, Bandgap, and Photocatalytic Hydrogen Evolution of (H2O/DMF)@HKUST‐1 Host‐Guest Systems.
- Author
-
Alfonso‐Herrera, Luis A., Rodríguez‐Girón, Jesús S., de Sampedro, Héctor I. González, Sánchez‐Martínez, Daniel, Navarrete‐López, Alejandra M., and Beltrán, Hiram I.
- Subjects
- *
STRUCTURAL stability , *CONDUCTION bands , *VALENCE bands , *HYDROGEN , *X-ray diffraction , *HYDROGEN evolution reactions - Abstract
The H2O@HKUST‐1 and DMF@HKUST‐1 systems were experimental and computationally assessed, employing XRD/TGA/FT‐IR/DFT‐calculations, evidencing that H2O or DMF coordinated to Cu, modulating HKUST‐1 photocatalytic properties. DMF@HKUST‐1 has narrower bandgap promoting higher‐crystallinity and light‐harvesting. H2O@HKUST‐1 showed smaller particle sizing and sharp morphology. Theoretical models, (H2O)1@HKUST‐1 and (DMF)1@HKUST‐1, containing one coordinated molecule, elucidated bandgap modulation associated with infiltration. H2O@HKUST‐1/DMF@HKUST‐1 presented bandgaps [eV] of 3.6/3.4, by Tauc plots, and 3.55/3.26, by theoretical calculations, narrowing bandgap, compared with non‐solvated HKUST‐1(HKUST‐1NS). Both composites raised the valence band (VB) and lowered the conduction band (CB), but DMF@HKUST‐1 most raised VB. Topological analysis revealed that guests i) with higher electronic density, raised VB, and ii) induced π‐backbonding, lowering CB. DMF@HKUST‐1 presented a higher photocatalytic hydrogen evolution (μmol), 26.45, in the first 30 min of the reaction, nevertheless, H2O@HKUST‐1 presented a competitive activity, of 17.32. In large periods, H2O@HKUST‐1/DMF@HKUST‐1 showed practically the same hydrogen evolution, 45.50/49.03. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. Gestational and Neonatal Outcomes of a New Three-Step Procedure for Emergency Cerclage
- Author
-
Morente, Lorena Sabonet, primary, Castellano, Manuel Gómez, additional, Mesa, Ernesto González, additional, and López, Jesús S Jiménez, additional
- Published
- 2024
- Full Text
- View/download PDF
24. Gradual change and mosaic pattern of macrofaunal assemblages along depth and sediment gradients in a tropical oceanic island.
- Author
-
Sibaja-Cordero, Jeffrey A. and Troncoso, Jesús S.
- Subjects
OCEAN zoning ,ECOLOGICAL disturbances ,MOSAICS (Art) ,ENVIRONMENTAL exposure ,POLYCHAETA - Abstract
The ecology of macrofauna on the sandy bottom of oceanic islands in the tropics has rarely been studied. The present study was conducted at Isla del Coco, Costa Rica, a tropical oceanic island, to determine how the soft-bottom macrofauna assemblages vary along different levels of ocean exposure and their associated environmental conditions. The macrofauna was collected from five grabs at each of the 27 stations (between 3 and 75 m deep) in April 2010. The broad-scale pattern consists of a gradual increase in the complexity of assemblages (taxonomical or feeding guilds in the sediment) from the inner part to the outside of the bays. The leading determinant of this pattern was the interplay between ocean exposure and sediment variation with depth that produces habitat heterogeneity. The main taxa responsible for differences between ocean exposure zones were the polychaetes Westheidesyllis heterocirrata and Magelona californica, the filter-feeding bivalve Gouldia californica, and the predatory isopod Eurydice caudata. Coarse bottoms had more mobile predators and suspension feeders, whereas passive suspension feeders or subsurface deposit feeders dominated fine sands. The deeper stations were dominated by organisms feeding actively on particles from the water or on the sediment surface. Moreover, more feeding guilds were found in deeper waters. Additionally, at the small-scale view (grabs within each station), macrofauna composition evidences a mosaic pattern, mainly at the inner and middle of the bays, caused by biological or environmental disturbances. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Clinical-epidemiological characterization of patients with long COVID in Mexico.
- Author
-
Del Carpio-Orantes, Luis, Trelles-Hernández, Daniela, García-Méndez, Sergio, Sánchez-Díaz, Jesús S., Aguilar-Silva, Andrés, and López-Vargas, Ener R.
- Abstract
Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
26. Increased Incidence of TdT-negative Pre-B Acute Lymphoblastic Leukemia Associated With Poor Prognostic Features Among Mexican Children in Central Mexico.
- Author
-
Vacek, Meagan, Zárraga Vargas, Laura C., González Domínguez, Elizabeth, Garcia Rodriguez, Lilia, Tello Teran, Omar A., Mojica Cardoso, Carlos, Ocampo Roosens, Luisa V., Acevedo Fernandez, Juan J., Li, Weijie, Lee, Brian, Olalla Tapia, Jesús S., and Flatt, Terrie
- Published
- 2024
- Full Text
- View/download PDF
27. The stress response of the seagrass Zostera noltei and three commercial clam species to low salinity associated with heavy rainfall.
- Author
-
Román, Salvador, Vázquez, Elsa, Román, Marta, Viejo, Rosa M, Weidberg, Nicolás, Troncoso, Jesús S, Woodin, Sarah A, Wethey, David S, and Olabarria, Celia
- Subjects
ZOSTERA ,MANILA clam ,SEAGRASSES ,SALINITY ,CLAMS ,SHELLFISH ,SPECIES - Abstract
The maintenance of stocks of estuarine species strongly depends on the ability of the species to cope with environmental stress. In NW Spain, commercial clam beds, which are usually co-occupied by the seagrass Zostera noltei , are often exposed to reduced salinity caused by intense rainfalls. Our goals were to evaluate the effects of low salinity events on both juvenile clams and Z. noltei , including their interactions. A mesocosm experiment was performed to simulate three salinity decreases (35–35, 25–10, and 20–5), and several indicators of clam and seagrass performance were measured after 3 and 6 days of exposure and again after a recovery period of 4 days. No differences were observed in the non-native clam Ruditapes philippinarum , while oxygen consumption, clearance rate and growth decreased significantly in the native clams R. decussatus and Venerupis corrugata in response to low salinity stress. Zostera noltei indicators did not vary in response to low salinity exposure, except the sucrose content, which decreased. Moreover, the seagrass buffered juvenile clams from salinity fluctuations in the short term, although the interactions were weak. The species-specific sensitivity to low salinity should be a major concern in future management plans for the shellfish beds in the context of climate change. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. Morphological and molecular characterization of Stomachicola muraenesocis Yamaguti, 1934 (Digenea: Hemiuridae) from the daggertooth pike conger Muraenesox cinereus (Forsskål).
- Author
-
Ghanei-Motlagh, Reza, Hernández-Orts, Jesús S., Fast, Mark D., Whyte, Shona K., El-Matbouli, Mansour, and Saleh, Mona
- Abstract
Hemiurid digeneans conspecific with Stomachicola muraenesocis Yamaguti, 1934 (the type species of the genus Stomachicola Yamaguti, 1934) were collected from the stomach of the daggertooth pike conger Muraenesox cinereus (Forsskål) off the Persian Gulf of Iran. This study aimed to provide a detailed characterization of Stom. muraenesocis , including measurements, illustrations and scanning electron microscopy (s.e.m.) representations. Comparisons with the original and previous descriptions revealed morphological and metrical variations in several features (i.e. body size and shape, arrangement of reproductive organs, soma to ecsoma length ratio, position of genital opening, number of vitelline tubules and extension of uterine coils) between Stom. muraenesocis from different hosts and localities. This study presents the first molecular sequence data associated with the small (18S) and large (28S) subunit nuclear ribosomal RNA genes (rDNA) for Stom. muraenesocis. Phylogenetic analyses of the 18S dataset placed Stom. muraenesocis as sister lineage to a clade formed of a group of species of Lecithaster Lühe, 1901 (Lecithasteridae Odhner, 1905). In contrast, phylogenetic analyses based on the 28S consistently recovered a sister relationship between Stom. muraenesocis and representatives of the Hemiuridae Looss, 1899. Further comprehensive phylogenetically based classification in light of morphology and taxonomic history of the Hemiuridae and Lecithasteridae is required to infer phylogenetic affinities and historical biogeography of Stomachicola. A comprehensive list of previously reported species of Stomachicola together with their associated hosts, localities and morphometric data is provided. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Combined Physiotherapy and Cognitive Behavioral Therapy for Functional Movement Disorders: A Randomized Clinical Trial.
- Author
-
Macías-García D, Méndez-Del Barrio M, Canal-Rivero M, Muñoz-Delgado L, Adarmes-Gómez A, Jesús S, Ojeda-Lepe E, Carrillo-García F, Palomar FJ, Gómez-Campos FJ, Martin-Rodriguez JF, Crespo-Facorro B, Ruiz-Veguilla M, and Mir P
- Subjects
- Humans, Female, Male, Middle Aged, Adult, Combined Modality Therapy, Single-Blind Method, Movement Disorders therapy, Aged, Treatment Outcome, Cognitive Behavioral Therapy methods, Physical Therapy Modalities, Quality of Life
- Abstract
Importance: Functional movement disorders (FMDs) are frequent and disabling neurological disorders with a substantial socioeconomic impact. Few randomized studies have analyzed the effectiveness of combined physiotherapy and psychotherapy in patients' quality of life., Objective: To assess the efficacy of multidisciplinary treatment (physiotherapy plus cognitive behavioral therapy) in FMDs., Design, Setting, and Participants: This was a parallel, rater-blinded, single-center, randomized clinical trial. Recruitment took place from June 2022 to April 2023, and follow-up visits were performed at months 3 and 5, concluding in October 2023. Participants were recruited from a national referral center for movement disorders: the Movement Disorders Unit from the Hospital Universitario Virgen Rocio in Seville, Spain. Patients had to be 18 years or older with a confirmed FMD diagnosis and capable of giving consent to participate. Patients who did not meet eligibility criteria or refused to participate were excluded. Any uncontrolled psychiatric disorder was considered an exclusion criterion., Interventions: Patients were randomly assigned, in a ratio of 1:1 to multidisciplinary treatment (physiotherapy plus cognitive behavioral therapy), or a control intervention (psychological support intervention)., Main Outcomes and Measures: Primary outcomes: between-group differences in changes from baseline to month 3 and month 5 in patients' quality of life (EQ-5D-5L score: EQ Index and EQ visual analog scale [EQ VAS]; and 36-Item Short-Form Survey Physical Component Summary [SF-36 PCS] and SF-36 Mental Component Summary [MCS]). Linear mixed models were applied, controlling by baseline severity and applying Bonferroni correction., Results: Of 70 patients screened with an FMD, 40 were enrolled (mean [SD] age, 43.5 [12.8] years; age range, 18-66 years; 32 female [80%]; mean [SD] age at FMD onset, 38.4 [12.1] years), and 38 completed all the follow-up visits and were included in the analysis for primary outcomes. Multidisciplinary treatment improved SF-36 PCS with a mean between-group difference at 3 months of 4.23 points (95% CI, -0.9 to 9.4 points; P = .11) and a significant mean between-group difference at 5 months of 5.62 points (95% CI, 2.3-8.9 points; P < .001), after multiple-comparisons adjustment. There were no significant differences in other quality-of-life outcomes such as SF-36 MCS (mean between-group difference at 3 and 5 months: 0.72 points; 95% CI, -5.5 to 7.0 points; P = .82 and 0.69 points; 95% CI, 2.3-8.9 points; P = .83, respectively), EQ VAS (9.34 points; 95% CI, -0.6 to 19.3 points; P = .07 and 13.7 points; 95% CI, -1.7 to 29.0 points; P = .09, respectively) and EQ Index (0.001 point; 95% CI, -0.1 to 0.1 point; P = .98 and 0.08 points; 95% CI, 0-0.2 points; P = .13, respectively). At months 3 and 5, 42% and 47% of patients, respectively, in the multidisciplinary group reported improved health using the EQ-5D system, compared with 26% and 16% of patients, respectively, in the control group., Conclusions and Relevance: Results show that multidisciplinary treatment (physiotherapy plus cognitive behavioral therapy) effectively improves FMD symptoms and physical aspects of patients' quality of life. Further studies must be performed to evaluate the potential cost-effectiveness of this approach in FMD., Trial Registration: ClinicalTrials.gov Identifier: NCT05634486.
- Published
- 2024
- Full Text
- View/download PDF
30. Peripheral immune profile and neutrophil-to-lymphocyte ratio in progressive supranuclear palsy: Case-control study and meta-analysis.
- Author
-
Muñoz-Delgado L, Luque-Ambrosiani A, Zamora BB, Macías-García D, Jesús S, Adarmes-Gómez A, Ojeda-Lepe E, Carrillo F, and Mir P
- Abstract
Background and Purpose: Peripheral inflammation is probably involved in the pathogenesis of progressive supranuclear palsy (PSP) and it may be a common feature with Parkinson's disease (PD). The peripheral immune profile in PSP remains unclear, as well as whether the inflammatory pathways differ from those in PD. The neutrophil-to-lymphocyte ratio (NLR) has been proven to be a well-established biomarker of systemic inflammation. This study aimed to evaluate the peripheral immune profile in PSP compared with PD., Methods: A cross-sectional study was conducted including patients with PSP and PD and healthy controls (HCs). Leukocyte subpopulations and the NLR were measured in peripheral blood. Multivariate linear regression and post hoc tests were applied. Electronic databases were searched in November 2023 to perform meta-analyses to clarify the peripheral immune profile in PSP., Results: Our cohort included 121 patients with PSP, 127 patients with PD and 266 HCs. The NLR was higher in PSP and PD compared with HCs. PSP had a higher neutrophil count compared with HCs. Whilst a lower lymphocyte count was found in PD compared with HCs, the lymphocyte count did not differ between PSP and HCs. The meta-analyses supported this immune profile., Conclusions: PSP and PD show an increased peripheral inflammation and a higher NLR compared with HCs. Different pathogenic inflammatory mechanisms are probably involved in PSP and PD, since in PSP this altered peripheral immune profile is mainly driven by neutrophils. Understanding the neutrophils' role in PSP may allow for the development of targeted therapies., (© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
- Published
- 2024
- Full Text
- View/download PDF
31. Zinc and Its Impact on the Function of the Testicle and Epididymis.
- Author
-
Marín de Jesús S, Vigueras-Villaseñor RM, Cortés-Barberena E, Hernández-Rodriguez J, Montes S, Arrieta-Cruz I, Pérez-Aguirre SG, Bonilla-Jaime H, Limón-Morales O, and Arteaga-Silva M
- Subjects
- Male, Humans, Animals, Spermatogenesis, Spermatozoa metabolism, Infertility, Male metabolism, Sperm Maturation physiology, Zinc metabolism, Epididymis metabolism, Testis metabolism
- Abstract
Zinc (Zn) is an essential trace element; it exhibits a plethora of physiological properties and biochemical functions. It plays a pivotal role in regulating the cell cycle, apoptosis, and DNA organization, as well as in protein, lipid, and carbohydrate metabolism. Among other important processes, Zn plays an essential role in reproductive health. The ZIP and ZnT proteins are responsible for the mobilization of Zn within the cell. Zn is an inert antioxidant through its interaction with a variety of proteins and enzymes to regulate the redox system, including metallothioneins (MTs), metalloenzymes, and gene regulatory proteins. The role of Zn in the reproductive system is of great importance; processes, such as spermatogenesis and sperm maturation that occur in the testicle and epididymis, respectively, depend on this element for their development and function. Zn modulates the synthesis of androgens, such as testosterone, for these reproductive processes, so Zn deficiency is related to alterations in sperm parameters that lead to male infertility.
- Published
- 2024
- Full Text
- View/download PDF
32. May Measurement Month 2021: an analysis of blood pressure screening results from Ecuador.
- Author
-
Peñaherrera E, Ramírez M, Peñaherrera R, Duarte YC, Cáceres S, Avila E, Jarrin E, Ullauri V, Aucancela H, Bayas M, Oña F, Arteaga F, Ruales J, Toopchiani S, Schlaich M, Poulter NR, Beaney T, and Liendo K Sr
- Abstract
Arterial hypertension is a growing burden worldwide, leading to over 10.8 million deaths each year. Before the outbreak of the COVID-19 pandemic, cardiovascular diseases were the main cause of death in Ecuador. Hypertension is the main risk factor for the major cause of death, coronary and cerebrovascular disease. The 2021 May Measurement Month Campaign (MMM21) is a global initiative by the International Society of Hypertension aimed at raising awareness of high blood pressure (BP) and to provide a temporary solution for opportunistic screening until more systematic approaches can be established. A cross-sectional survey was carried out in May 2021 across 22 health centres in Ecuador. The average age of participants was 44.7 ± 15.8 years. Blood pressure measurement, the definition of hypertension (mean of the 2nd and 3rd BP measurements ≥ 140/90 mmHg or on medication for high BP), and statistical analysis followed the standard MMM protocol. In total, 1326 volunteers participated in MMM21. After multiple imputation of missing BP readings, 423 (31.9%) had hypertension. Of those, 70.5% were receiving antihypertensive medication. Of individuals receiving antihypertensive medication, 50.0% had uncontrolled BP. Overall, of 423 participants with hypertension, only 35.2% had their BP controlled (<140/90 mmHg). MMM21 demonstrated a high prevalence of hypertension in Ecuador during the COVID-19 pandemic. It was the largest BP screening campaign done in Ecuador thus far. The high percentage of persons untreated or with uncontrolled hypertension while on pharmacologic treatment suggests that appropriate screening can help to identify a significant number of people with elevated BP and those inadequately treated. These data should attract the attention of doctors and health care providers in Ecuador., Competing Interests: Conflict of interest: The author and co-authors declare that they have no conflicts of interest for the present study., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2024
- Full Text
- View/download PDF
33. Role of ATP10B in Parkinson disease in a cohort from southern Spain.
- Author
-
Díaz-Belloso R, Muñoz-Delgado L, Martín-Bornez M, Ojeda E, Periñán MT, García-Díaz S, Bonilla-Toribio M, Buiza-Rueda D, Pineda-Sánchez R, Jesús S, Macías-García D, Adarmes-Gómez A, Carrillo F, Mir P, and Gómez-Garre P
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Cohort Studies, Genetic Predisposition to Disease, Spain epidemiology, Membrane Transport Proteins genetics, Membrane Transport Proteins metabolism, Adenosine Triphosphatases genetics, Adenosine Triphosphatases metabolism, Parkinson Disease genetics
- Abstract
The ATP10B gene has been proposed to play an important role in the development of early-onset Parkinson's disease (PD). Nevertheless, various studies have presented controversial conclusions regarding the involvement of this gene in PD. Here, we screened 1162 patients with PD, employing a targeted resequencing approach to investigate the putative relevance of this gene in a large independent cohort of these patients from southern Spain. Variations were classified according to the American College of Medical Genetics and Genomics criteria. Association studies were performed using data of a representative healthy Spanish population from the Medical Genome Project. Frequent variants were excluded. A total of 68 variants (rare or very rare) were detected in our cohort. Among ATP10B variant carriers, 12.9 % were putative compound heterozygous carriers; of these, 25 % were patients with early-onset PD. No evidence of a relation between any rare variants of ATP10B and PD risk was observed. Therefore, our results do not support a role for ATP10B in the onset of PD, or in the risk of developing it., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
34. Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS.
- Author
-
Marriott H, Spargo TP, Al Khleifat A, Andersen PM, Başak NA, Cooper-Knock J, Corcia P, Couratier P, de Carvalho M, Drory V, Gotkine M, Landers JE, McLaughlin R, Pardina JSM, Morrison KE, Pinto S, Shaw CE, Shaw PJ, Silani V, Ticozzi N, van Damme P, van den Berg LH, Vourc'h P, Weber M, Veldink JH, Dobson RJ, Schwab P, Al-Chalabi A, and Iacoangeli A
- Subjects
- Humans, Genetic Predisposition to Disease genetics, Mutation, Mutation, Missense, Protein Domains genetics, Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis epidemiology, Neurofilament Proteins genetics
- Abstract
Objective: Neurofilament heavy-chain gene (NEFH) variants are associated with multiple neurodegenerative diseases, however, their relationship with ALS has not been robustly explored. Still, NEFH is commonly included in genetic screening panels worldwide. We therefore aimed to determine if NEFH variants modify ALS risk., Methods: Genetic data of 11,130 people with ALS and 7,416 controls from the literature and Project MinE were analysed. We performed meta-analyses of published case-control studies reporting NEFH variants, and variant analysis of NEFH in Project MinE whole-genome sequencing data., Results: Fixed-effects meta-analysis found that rare (MAF <1%) missense variants in the tail domain of NEFH increase ALS risk (OR 4.55, 95% CI 2.13-9.71, p < 0.0001). In Project MinE, ultrarare NEFH variants increased ALS risk (OR 1.37 95% CI 1.14-1.63, p = 0.0007), with rod domain variants (mostly intronic) appearing to drive the association (OR 1.45 95% CI 1.18-1.77, p
Madsen-Browning = 0.0007, pSKAT-O = 0.003). While in the tail domain, ultrarare (MAF <0.1%) pathogenic missense variants were also associated with higher risk of ALS (OR 1.94, 95% CI 0.86-4.37, pMadsen-Browning = 0.039), supporting the meta-analysis results. Finally, several tail in-frame deletions were also found to affect disease risk, however, both protective and pathogenic deletions were found in this domain, highlighting an intricate architecture that requires further investigation., Interpretation: We showed that NEFH tail missense and in-frame deletion variants, and intronic rod variants are risk factors for ALS. However, they are not variants of large effect, and their functional impact needs to be clarified in further studies. Therefore, their inclusion in routine genetic screening panels should be reconsidered., (© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)- Published
- 2024
- Full Text
- View/download PDF
35. Levodopa-Induced Dyskinesias are Frequent and Impact Quality of Life in Parkinson's Disease: A 5-Year Follow-Up Study.
- Author
-
Santos-García D, de Deus T, Cores C, Feal Painceiras MJ, Íñiguez Alvarado MC, Samaniego LB, López Maside A, Jesús S, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández-Vara J, Cabo López I, López Manzanares L, González-Aramburu I, Ávila A, Gómez-Mayordomo V, Nogueira V, Dotor García-Soto J, Borrué-Fernández C, Solano B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Mendoza Z, Pareés I, Sánchez Alonso P, Alonso Losada MG, López-Ariztegui N, Gastón I, Kulisevsky J, Seijo M, Valero C, Alonso Redondo R, Buongiorno MT, Ordás C, Menéndez-González M, McAfee D, Martinez-Martin P, and Mir P
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Follow-Up Studies, Severity of Illness Index, Levodopa adverse effects, Parkinson Disease drug therapy, Quality of Life, Dyskinesia, Drug-Induced epidemiology, Dyskinesia, Drug-Induced etiology, Antiparkinson Agents adverse effects
- Abstract
Background: Levodopa-induced dyskinesias (LID) are frequent in Parkinson's disease (PD)., Objective: To analyze the change in the frequency of LID over time, identify LID related factors, and characterize how LID impact on patients' quality of life (QoL)., Patients and Methods: PD patients from the 5-year follow-up COPPADIS cohort were included. LID were defined as a non-zero score in the item "Time spent with dyskinesia" of the Unified Parkinson's Disease Rating Scale-part IV (UPDRS-IV). The UPDRS-IV was applied at baseline (V0) and annually for 5 years. The 39-item Parkinson's disease Questionnaire Summary Index (PQ-39SI) was used to asses QoL., Results: The frequency of LID at V0 in 672 PD patients (62.4 ± 8.9 years old; 60.1% males) with a mean disease duration of 5.5 ± 4.3 years was 18.9% (127/672) and increased progressively to 42.6% (185/434) at 5-year follow-up (V5). The frequency of disabling LID, painful LID, and morning dystonia increased from 6.9%, 3.3%, and 10.6% at V0 to 17.3%, 5.5%, and 24% at V5, respectively. Significant independent factors associated with LID (P < 0.05) were a longer disease duration and time under levodopa treatment, a higher dose of levodopa, a lower weight and dose of dopamine agonist, pain severity and the presence of motor fluctuations. LID at V0 (β = 0.073; P = 0.027; R
2 = 0.62) and to develop disabling LID at V5 (β = 0.088; P = 0.009; R2 = 0.73) were independently associated with a higher score on the PDQ-39SI., Conclusion: LID are frequent in PD patients. A higher dose of levodopa and lower weight were factors associated to LID. LID significantly impact QoL., (© 2024 International Parkinson and Movement Disorder Society.)- Published
- 2024
- Full Text
- View/download PDF
36. Elucidating Structural Stability, Bandgap, and Photocatalytic Hydrogen Evolution of (H 2 O/DMF)@HKUST-1 Host-Guest Systems.
- Author
-
Alfonso-Herrera LA, Rodríguez-Girón JS, de Sampedro HIG, Sánchez-Martínez D, Navarrete-López AM, and Beltrán HI
- Abstract
The H
2 O@HKUST-1 and DMF@HKUST-1 systems were experimental and computationally assessed, employing XRD/TGA/FT-IR/DFT-calculations, evidencing that H2 O or DMF coordinated to Cu, modulating HKUST-1 photocatalytic properties. DMF@HKUST-1 has narrower bandgap promoting higher-crystallinity and light-harvesting. H2 O@HKUST-1 showed smaller particle sizing and sharp morphology. Theoretical models, (H2 O)1 @HKUST-1 and (DMF)1 @HKUST-1, containing one coordinated molecule, elucidated bandgap modulation associated with infiltration. H2 O@HKUST-1/DMF@HKUST-1 presented bandgaps [eV] of 3.6/3.4, by Tauc plots, and 3.55/3.26, by theoretical calculations, narrowing bandgap, compared with non-solvated HKUST-1(HKUST-1NS ). Both composites raised the valence band (VB) and lowered the conduction band (CB), but DMF@HKUST-1 most raised VB. Topological analysis revealed that guests i) with higher electronic density, raised VB, and ii) induced π-backbonding, lowering CB. DMF@HKUST-1 presented a higher photocatalytic hydrogen evolution (μmol), 26.45, in the first 30 min of the reaction, nevertheless, H2 O@HKUST-1 presented a competitive activity, of 17.32. In large periods, H2 O@HKUST-1/DMF@HKUST-1 showed practically the same hydrogen evolution, 45.50/49.03., (© 2023 The Authors. ChemPlusChem published by Wiley-VCH GmbH.)- Published
- 2024
- Full Text
- View/download PDF
37. Postcranial anomalies of Eocene freshwater pleurodiran and cryptodiran turtles from the Spanish Duero Basin.
- Author
-
Guerrero A, Ortega F, Martín de Jesús S, and Pérez-García A
- Abstract
Testudines are one of the best-represented taxonomic groups among the Paleogene taxa of the Duero Basin (Castile and Leon Autonomous Community, central Spain). Among them, Neochelys (Podocnemidide) and Allaeochelys (Carettochelyidae) are most abundant, allowing the population to be assessed for osteological anomalies. The abundance of postcranial remains of both taxa allows us to identify several individuals with potential anomalies, mostly in their shells. Some of them have already been described in previous studies, but most of them are still unpublished. The objective of this study is to analyze in detail the anomalous Neochelys and Allaeochelys remains. As a result, different categories of causal agents (such as bacteria, fungi, parasites, or trauma) have been identified as potential producers of the anomalies in these freshwater turtles. Information regarding the pathogenesis and healing stages of some of these anomalies is provided., (© 2024 The Authors. The Anatomical Record published by Wiley Periodicals LLC on behalf of American Association for Anatomy.)
- Published
- 2024
- Full Text
- View/download PDF
38. A new Crocodyloidea from the middle Eocene of Zamora (Duero Basin, Spain).
- Author
-
Narváez I, de Celis A, Escaso F, Martín de Jesús S, Pérez-García A, and Ortega F
- Abstract
The eusuchian crocodyliforms recorded in the Eocene levels of the Spanish Duero Basin belong to three lineages: Planocraniidae, with the species Duerosuchus piscator; Alligatoroidea, represented by several specimens of the genus Diplocynodon; and Crocodyloidea, which includes several specimens traditionally attributed to Asiatosuchus. The genus Asiatosuchus, established in 1940 based on a middle Eocene species from Mongolia, has subsequently served as a wastebasket taxon for Paleogene remains belonging to several species, not only from Asia but also belonging to the European and North American records. Many of these species are known by highly fragmentary remains, sharing the presence of characters such as a flat and triangular skull, and long symphyses in the lower jaw, recognized as characteristic for the crocodyloids. In addition to isolated cranial remains, among the material traditionally attributed to Asiatosuchus at the Duero Basin stands out a nearly complete skull and a left mandible, from the middle Eocene area of Casaseca de Campeán (Zamora Province). The present study analyses in detail these specimens, previously reported during the 1980s, but analyzed in a very preliminary way. They are included for the first time in a phylogenetic analysis to establish the systematic position of this Spanish form. The results confirm that it corresponds to a new species of basal crocodyloid, defined here as Asiatosuchus oenotriensis sp. nov., (© 2024 The Authors. The Anatomical Record published by Wiley Periodicals LLC on behalf of American Association for Anatomy.)
- Published
- 2024
- Full Text
- View/download PDF
39. Large-Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes.
- Author
-
Thomsen M, Marth K, Loens S, Everding J, Junker J, Borngräber F, Ott F, Jesús S, Gelderblom M, Odorfer T, Kuhlenbäumer G, Kim HJ, Schaeffer E, Becktepe J, Kasten M, Brüggemann N, Pfister R, Kollewe K, Krauss JK, Lohmann E, Hinrichs F, Berg D, Jeon B, Busch H, Altenmüller E, Mir P, Kamm C, Volkmann J, Zittel S, Ferbert A, Zeuner KE, Rolfs A, Bauer P, Kühn AA, Bäumer T, Klein C, and Lohmann K
- Subjects
- Humans, Mutation genetics, Gene Frequency, Molecular Chaperones genetics, DNA-Binding Proteins genetics, Apoptosis Regulatory Proteins genetics, Dystonia genetics, Dystonic Disorders genetics, Parkinson Disease genetics
- Abstract
Background: Pathogenic variants in several genes have been linked to genetic forms of isolated or combined dystonia. The phenotypic and genetic spectrum and the frequency of pathogenic variants in these genes have not yet been fully elucidated, neither in patients with dystonia nor with other, sometimes co-occurring movement disorders such as Parkinson's disease (PD)., Objectives: To screen >2000 patients with dystonia or PD for rare variants in known dystonia-causing genes., Methods: We screened 1207 dystonia patients from Germany (DysTract consortium), Spain, and South Korea, and 1036 PD patients from Germany for pathogenic variants using a next-generation sequencing gene panel. The impact on DNA methylation of KMT2B variants was evaluated by analyzing the gene's characteristic episignature., Results: We identified 171 carriers (109 with dystonia [9.0%]; 62 with PD [6.0%]) of 131 rare variants (minor allele frequency <0.005). A total of 52 patients (48 dystonia [4.0%]; four PD [0.4%, all with GCH1 variants]) carried 33 different (likely) pathogenic variants, of which 17 were not previously reported. Pathogenic biallelic variants in PRKRA were not found. Episignature analysis of 48 KMT2B variants revealed that only two of these should be considered (likely) pathogenic., Conclusion: This study confirms pathogenic variants in GCH1, GNAL, KMT2B, SGCE, THAP1, and TOR1A as relevant causes in dystonia and expands the mutational spectrum. Of note, likely pathogenic variants only in GCH1 were also found among PD patients. For DYT-KMT2B, the recently described episignature served as a reliable readout to determine the functional effect of newly identified variants. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., (© 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
- Published
- 2024
- Full Text
- View/download PDF
40. Clinical-epidemiological characterization of patients with long COVID in Mexico.
- Author
-
Carpio-Orantes LD, Trelles-Hernández D, García-Méndez S, Sánchez-Díaz JS, Aguilar-Silva A, and López-Vargas ER
- Subjects
- Humans, Mexico epidemiology, Female, Male, Adult, Middle Aged, Risk Factors, Post-Acute COVID-19 Syndrome, Severity of Illness Index, Young Adult, Aged, COVID-19 Vaccines, Obesity epidemiology, Obesity complications, Surveys and Questionnaires, COVID-19 epidemiology
- Abstract
Background: Long COVID is defined as the persistence of COVID-19 symptoms four weeks after having undergone acute infection, according to the most recent CDC definition. It is estimated that there are 65 million people affected by this entity, although other figures speak of 200 million., Objective: To characterize the population affected by long COVID in Mexico., Material and Methods: Patients older than 18 years who agreed to answer an online survey and who met the criteria for long COVID were included., Results: Data from 203 subjects were included, with 138 (68.0%) being found to be females, and average age to be 41.8 years; 29.6% had severe disease, and 70.4%, mild to moderate disease; 89.7% had received prior COVID-19 vaccination: 6.9% had received one dose; 31.5%, two doses; and 51.2%, three or more doses. The main risk factors were diabetes, overweight or obesity, and hypertension. The most commonly reported symptom was fatigue, followed by other neuropsychiatric manifestations., Conclusion: It is important for the population affected by long COVID to be characterized in order to generate diagnostic and treatment protocols., (Copyright: © 2024 Permanyer.)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.