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Background: Military personnel face an increased risk of developing mental disorders owing to the stressful environments they encounter. Effective stress management strategies are crucial to mitigate this risk. Mindfulness training (MT) is promising as a stress management approach in such demanding settings. This study uses a quantitative approach to investigate the impact of MT on the relationship between the autonomic nervous system (ANS) and emotional regulation., Methods: The study evaluated the effectiveness of MT in reducing stress among 86 military personnel. Participants were divided into two groups: MT (n = 42) and non-MT (n = 38). The study compared the two groups using measures of heart rate variability (HRV), a reliable indicator of ANS activity., Results: The MT group exhibited a significant increase in HRV (14.4%, p = 0.001) and alpha asymmetry (AA) in the frontal lobe (45.7%, p < 0.001) compared to the non-MT group. Notably, the MT group achieved significantly higher scores on the parachute landing fall (PLF) training performance (p < 0.001). These improvements in HRV, AA, and PLF performance were strongly correlated. Furthermore, AA fully mediated the relationship between HRV and PLF training performance., Conclusions: The findings suggest that MT has a positive impact on stress resilience, potentially by mitigating anxiety and attention deficits induced by extreme stressors. These positive effects are facilitated by concurrent modulation of the frontal cortex and autonomic nervous system. Our findings provide insight into the neural mechanisms behind MT-induced stress reduction from the perspective of neuromodulation., Competing Interests: Declarations. Ethics approval and consent to participate: The Institutional Review Board of the Korea University (KUIRB-2023-0058-01) approved the experimental protocol. Informed consent was obtained from all participants, and the right to withdraw from the experiment without any negative consequences was instructed. Informed consent was obtained from all the participants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

Several donor-specific factors influence the functional recovery and long-term outcomes of liver grafts. This study investigated the association between donor fasting glucose (DFG) and recipient outcomes after living donor liver transplantation (LDLT) in 950 cases at a single center. Patients were divided into two groups: low-DFG (< 85 mg/dL, n = 120) and control (≥ 85 mg/dL, n = 830). The five-year graft survival rate was significantly lower in the low-DFG group (71.5%) compared to the control group (80.0%) (P = 0.02). Multivariable Cox regression analysis showed that low DFG was independently associated with graft loss (hazard ratio 1.72, 95% CI 1.15-2.56, P = 0.008). In propensity score-matched groups, the low-DFG group also had lower survival rates (71% vs. 83.1%, P = 0.004). The presence of additional risk factors, such as low graft-to-recipient weight ratio, older donor age, and longer cold ischemic time, further reduced graft survival in the low-DFG group. A DFG level < 85 mg/dL is associated with higher risk of graft failure after LDLT, especially when combined with other risk factors. Low DFG should be considered a prognostic marker in LDLT planning, with potential to improve patient outcomes as further research clarifies the underlying pathophysiological mechanisms., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Background: Acute-on-chronic liver failure (ACLF) is a syndrome of patients with chronic liver disease presenting with multiple organ failures. Recently, Sundaram-ACLF-LT Mortality (SALT-M) score has been developed to predict 1-year post-liver transplantation mortality. We validated the SALT-M score in a large-volume, Asian single-centre cohort., Aims: We validated the SALT-M score in a large-volume, Asian single-centre cohort., Methods: We analysed 224 patients of ACLF grade 2-3. Area under the receiver operating characteristic curve (AUROC) and concordance index (c-index) were used to assess and compare the predictability of posttransplant mortality of SALT-M and other scores. Moreover, we compared the survivals of patients with high and low SALT-M, in conjunction with MELD score and ACLF grade., Results: The AUROC for prediction of 1-year post-LT survival was higher in SALT-M (0.691) than in MELD, MELD-Na, MELD 3.0 and delta-MELD. Similarly, the c-index of the SALT-M (0.650) was higher than aforementioned MELD systems. When categorised by the cut-off of SALT-M ≥ 20 and MELD ≥ 30, patients with high SALT-M exhibited lower post-LT survival than those with low SALT-M scores regardless of high or low MELD (40.0% for high SALT-M/high MELD vs. 42.9% for high SALT-M/low MELD vs. 73.8% for low SALT-M/high MELD vs. 63.7% for low SALT-M/low MELD, p < 0.001). In patients with ACLF grade 3, SALT-M effectively stratified the posttransplant mortality (39.4% for high SALT-M vs. 63.1% for low SALT-M, p = 0.018)., Conclusions: SALT-M outperformed previous MELD systems for predicting posttransplant mortality in Asian LT cohort with severe ACLF. Transplantability for patients with severe ACLF could be determined based on SALT-M., (© 2024 John Wiley & Sons Ltd.)