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Background: Karnataka ranks third with regards the number of mines in India and Kolar, at one time, had the world’s deepest and most productive gold mines. Miners are exposed to hazardous agents like silica, coal and asbestos which adversely impact health. Objectives: To assess the health-related quality of life (HRQL) of ex-mine workers at Kolar Gold Fields (KGF), Kolar, Karnataka. Methodology: An analytical cross-sectional study was conducted among 240 (estimated 196 with 50% prevalence) male ex-mine workers of KGF. An interview scheduled, consisting of socio-demographic factors, COPD Assessment Test (CAT) and Kings Brief Interstitial Lung Disease (KBILD) was administered. Lower CAT score and higher KBILD score indicate better HRQOL. Results: The mean age of the participants was 69.71±8.56 years. Participants were previously involved in drilling (113-47%) and blasting (127-53%) activities in the mines, with a mean of 14.68±6.46 years of work exposure. The mean scores for CAT and KBILD were 15.80±7.42 and 52.83±8.77 respectively. Based on CAT scores, half (51%) of participants reported medium impact of COPD on their health. Participants with longer duration of work experience had significantly higher CAT scores [OR-36.64 (12.14-110.6)]. KBILD score was significantly higher among those who worked in blasting (M=113. SD=52.14) than those involved in drilling (M=127, SD=53.43). Lower duration of work was significantly associated with higher KBILD scores (p

Congenital heart defects (CHDs) contribute significantly to heightened infant mortality rates. This review explores the intricate link between maternal infections and CHDs, emphasizing diverse factors influencing fetal development, such as bacterial, fungal, protozoan and viral agents. These infections pose reproductive health risks, potentially leading to complications like prematurity, stillbirth and heart defect to the fetus. The TORCH acronym (Toxoplasma, Other infections, Rubella, Cytomegalovirus, Herpes simplex) identifies infectious teratogens related to congenital issues, emphasizing vertical transmission through the placenta or ascending from the vagina. Rubella and Cytomegalovirus play a significant role in heart defects, particularly when maternal infections amplify CHD risk during pregnancy. Specific scrutiny is placed on Rubella and Cytomegalovirus for their impact on pregnancy outcomes and potential links to congenital heart defects, with preventive strategies discussed, including vaccination and antiviral therapy. The timing and severity of these infections are pivotal in determining their impact on fetal heart development. Environmental exposures and maternal nutrition are critical factors influencing fetal development. Maternal undernutrition in low- and middle-income countries associates with adverse pregnancy outcomes, including congenital heart defects. Emphasizing the importance of maintaining a nutritious maternal diet, rich in essential nutrients, is crucial for improved fetal health and successful pregnancy outcomes. This review offers insights into preventive measures and underscores the need for continued research to enhance prenatal care strategies. [ABSTRACT FROM AUTHOR]

Introduction: This cohort study aimed to compare the effect of ultrasonic scaling on the expression of IL-1β in the gingival crevicular fluid (GCF) among ENDS users and non-smokers (NS) with gingivitis., Methods: Self-reported current electronic nicotine delivery system (ENDS) users and NS with generalized gingivitis were included in this study. All the patients underwent scaling at the baseline visit (T0). Clinical measures, periodontal parameters [probing depth (PD), plaque index (PI), and bleeding on probing (BOP)], and GCF IL-1β were measured at T0, after 1 week (T1) and after 3 weeks (T2). Wilcoxon signed rank test was used to assess the changes in the periodontal measurements and IL-1β levels at different time points and Mann-Whitney U Test was used to compare the two groups., Results: A total of 38 individuals (18 NS and 20 ENDS users) participated in the study. The PD was significantly higher in ENDS users than in NS at baseline. However, the PI and BOP were similar in all groups at baseline. At T1, the PI was significantly lower for NS than for ENDS users (p=0.045). At T2, there were no significant differences in any of the parameters assessed between the two groups. For ENDS users, BOP was significantly lower at T1 than at baseline. For NS, the BOP at T1 and T2 and the PI at T1 were significantly lower than at baseline. There was no difference in the GCF IL-1β levels in NS and ENDS users at baseline, T1, and T2. At T2, there was a significant reduction in IL-1β (p<0.05) than at baseline in both groups., Conclusions: Both ENDS users and NS with gingivitis responded similarly to scaling. GCF IL-1β levels were significantly higher at baseline (p<0.05) compared with their levels at T1 and T2 for both the groups., Clinical Trial Registration: The study was registered on the official website of ClinicalTrials.gov., Identifier: ID NCT05745324., Competing Interests: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported., (© 2024 Alkhalifah A.B. et al.)