1. Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs
- Author
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Julia Bauer, Julia Vlcek, Valerie Pauly, Nora Hesse, Ruibing Xia, Li Mo, Aparna Sharma Chivukula, Hannes Villgrater, Marie Dressler, Bianca Hildebrand, Eckhard Wolf, Konstantinos D. Rizas, Axel Bauer, Stefan Kääb, Philipp Tomsits, Dominik Schüttler, and Sebastian Clauss
- Subjects
autonomic remodeling ,ischemic heart failure ,periodic repolarization dynamics ,pig model ,sudden cardiac death ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Periodic repolarization dynamics (PRD) is an electrocardiographic biomarker that captures repolarization instability in the low frequency spectrum and is believed to estimate the sympathetic effect on the ventricular myocardium. High PRD indicates an increased risk for postischemic sudden cardiac death (SCD). However, a direct link between PRD and proarrhythmogenic autonomic remodeling has not yet been shown. Methods and Results We investigated autonomic remodeling in pigs with myocardial infarction (MI)–related ischemic heart failure induced by balloon occlusion of the left anterior descending artery (n=17) compared with pigs without MI (n=11). Thirty days after MI, pigs demonstrated enhanced sympathetic innervation in the infarct area, border zone, and remote left ventricle paralleled by altered expression of autonomic marker genes/proteins. PRD was enhanced 30 days after MI compared with baseline (pre‐MI versus post‐MI: 1.75±0.30 deg2 versus 3.29±0.79 deg2, P
- Published
- 2024
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