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Background: Post-operative sore throat (POST) can be a cause of great discomfort after endotracheal intubation with an incidence of up to 65%. While there are studies demonstrating the efficacy of prophylactic zinc lozenges in decreasing POST in patients intubated using MacIntosh laryngoscope, similar studies with King Vision video laryngoscope (KVVL) are lacking. Hence, we conducted this study to assess whether similar beneficial effects can be seen in South Indian patients. Aims and Objectives: The primary objective was to evaluate the efficacy of prophylactic zinc lozenges for the prevention of POST in patients intubated using channeled KVVL. The Secondary objectives were to assess the severity of POST, the duration of laryngoscopy, and the number of intubation attempts and their effect on POST. Materials and Methods: In this prospective comparative trial, 94 American Society of Anesthesiologists physical status one and two patients, randomized into two groups received either 40 mg of a zinc lozenge or a placebo, 30 min before endotracheal intubation POST was evaluated after surgery at 0, 2, 4, 6, and 24 h. Results: The overall incidence of POST in the zinc group was 13.18% and in the placebo group was 26.37% resulting in an almost 50% reduction in the overall incidence of POST. Conclusion: The administration of zinc lozenge 30 min preoperatively is effective to reduce the incidence of POST in the immediate and early post-operative period. [ABSTRACT FROM AUTHOR]

Background: Fentanyl-induced cough (FIC) is an undesirable side effect associated with intravenous injection of the opioid fentanyl, which can lead to an increase in intraocular, intrathoracic, and intraabdominal pressures. The incidence of FIC is reported to be 18-65%, more common in young females, who are also at high risk population for post-operative nausea and vomiting (PONV). FIC and PONV are both common anesthesia-related events that seem to have common risk factors. Aims and Objectives: The objectives of the study were to find out the incidence of FIC in female patients undergoing elective surgery under general anesthesia and if FIC was a risk factor for developing PONV. Materials and Methods: A randomized, prospective study was done to compare the incidence of FIC and its correlation with PONV. 263 adult female patients belonging to American Society of Anesthesiologists status I and II, aged 18-59 years, posted for elective surgery under general anesthesia were studied over a period of 2 years. Pre-operatively, fentanyl (2 mg/kg body weight) was injected intravenously over 10 s as premedication, and the occurrence of any episode of cough within 60 s of fentanyl administration was taken as FIC. The incidence and severity of PONV were assessed in the same study population for a 24-h period. The incidence of FIC during general anesthesia in the study population was noted, and its correlation with PONV was analyzed. Results: The incidence of FIC in the study population was found to be 27%. The incidence of PONV in the FIC group was found to be 38%, as compared to 29.7% in the non-FIC group. FIC group had a higher incidence of PONV than the non-FIC group, but it was statistically insignificant (P=0.254). Conclusion: The incidence of PONV was slightly higher in the FIC group than in the non-FIC group, but it was not statistically significant. [ABSTRACT FROM AUTHOR]