13 results on '"Ko, Li"'
Search Results
2. Successful Recanalization and Neurological Restoration in Cancerous Embolic Cerebral Infarction via Endovascular Stent-Retriever Embolectomy.
- Author
-
Ko, Li-Ying, Kok, Victor C, Tang, Chun-Hao, Lee, Chien-Kuan, and Yen, Pao-Sheng
- Subjects
- *
ISCHEMIC stroke , *CEREBRAL embolism & thrombosis , *CEREBRAL infarction , *ENDOVASCULAR surgery , *STROKE , *FACIAL paralysis - Abstract
Mechanical thrombectomy has emerged as a promising treatment for acute ischemic stroke caused by large vessel occlusion. However, cases involving cancerous emboli retrieved during endovascular embolectomy are rare. We present a case of a 65-year-old man with a history of heavily treated rectal cancer, who developed a middle cerebral artery (MCA) infarction due to metastatic adenocarcinoma. The patient presented with sudden onset right-side weakness, right facial palsy, global aphasia, and left gaze deviation, with a National Institutes of Health Stroke Scale (NIHSS) score of 16. Following intravenous thrombolysis, endovascular thrombectomy was performed, achieving nearly complete recanalization. Pathological examination of the retrieved thrombus revealed metastatic adenocarcinoma of rectal origin. The patient's neurological deficits gradually improved, and he was successfully discharged to undergo further palliative therapy. This case underscores the importance of considering mechanical thrombectomy for patients with advanced solid organ malignancy presenting with acute ischemic stroke, even when the etiology could be a tumor embolus. Our findings highlight the potential for mechanical thrombectomy to restore neurological function in such cases, allowing patients to proceed to the next level of care with a reasonably good post-stroke quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Time synchronization between parietal–frontocentral connectivity with MRCP and gait in post-stroke bipedal tasks.
- Author
-
Phang, Chun-Ren, Su, Kai-Hsiang, Cheng, Yuan-Yang, Chen, Chia-Hsin, and Ko, Li-Wei
- Subjects
KNEE ,PEARSON correlation (Statistics) ,ROBOTIC exoskeletons ,GAIT in humans ,SUPPORT vector machines ,FUNCTIONAL connectivity ,SYNCHRONIZATION - Abstract
Background: In post-stroke rehabilitation, functional connectivity (FC), motor-related cortical potential (MRCP), and gait activities are common measures related to recovery outcomes. However, the interrelationship between FC, MRCP, gait activities, and bipedal distinguishability have yet to be investigated. Methods: Ten participants were equipped with EEG devices and inertial measurement units (IMUs) while performing lower limb motor preparation (MP) and motor execution (ME) tasks. MRCP, FCs, and bipedal distinguishability were extracted from the EEG signals, while the change in knee degree during the ME phase was calculated from the gait data. FCs were analyzed with pairwise Pearson's correlation, and the brain-wide FC was fed into support vector machine (SVM) for bipedal classification. Results: Parietal–frontocentral connectivity (PFCC) dysconnection and MRCP desynchronization were related to the MP and ME phases, respectively. Hemiplegic limb movement exhibited higher PFCC strength than nonhemiplegic limb movement. Bipedal classification had a short-lived peak of 75.1% in the pre-movement phase. These results contribute to a better understanding of the neurophysiological functions during motor tasks, with respect to localized MRCP and nonlocalized FC activities. The difference in PFCCs between both limbs could be a marker to understand the motor function of the brain of post-stroke patients. Conclusions: In this study, we discovered that PFCCs are temporally dependent on lower limb gait movement and MRCP. The PFCCs are also related to the lower limb motor performance of post-stroke patients. The detection of motor intentions allows the development of bipedal brain-controlled exoskeletons for lower limb active rehabilitation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Developing a reliable and practical multi-domain model to facilitate the diagnosis of ADHD in older preschool children
- Author
-
Chen, I-Chun, primary, Chang, Che-Lun, additional, Chang, Meng-Han, additional, and Ko, Li-Wei, additional
- Published
- 2024
- Full Text
- View/download PDF
5. Temporal alpha dissimilarity of ADHD brain network in comparison with CPT and CATA
- Author
-
Lin, Jo-Wei, primary, Fan, Zuo-Cian, additional, Tzou, Shey-Cherng, additional, Wang, Liang-Jen, additional, and Ko, Li-Wei, additional
- Published
- 2024
- Full Text
- View/download PDF
6. Extracting Stress-Related EEG Patterns from Pre-Sleep EEG for Forecasting Slow-Wave Sleep Deficiency
- Author
-
Su, Cheng-Hua, primary, Ko, Li-Wei, additional, Jung, Tzyy-Ping, additional, Onton, Julie, additional, Tzou, Shey-Cherng, additional, Juang, Jia-chi, additional, and Hsu, Chung-Yao, additional
- Published
- 2024
- Full Text
- View/download PDF
7. Development of an Adaptive Artifact Subspace Reconstruction Based on Hebbian/Anti-Hebbian Learning Networks for Enhancing BCI Performance
- Author
-
Tsai, Bo-Yu, Diddi, Sandeep Vara Sankar, Ko, Li-Wei, Wang, Shuu-Jiun, Chang, Chi-Yuan, and Jung, Tzyy-Ping
- Abstract
Brain–computer interface (BCI) actively translates the brain signals into executable actions by establishing direct communication between the human brain and external devices. Recording brain activity through electroencephalography (EEG) is generally contaminated with both physiological and nonphysiological artifacts, which significantly hinders the BCI performance. Artifact subspace reconstruction (ASR) is a well-known statistical technique that automatically removes artifact components by determining the rejection threshold based on the initial reference EEG segment in multichannel EEG recordings. In real-world applications, the fixed threshold may limit the efficacy of the artifact correction, especially when the quality of the reference data is poor. This study proposes an adaptive online ASR technique by integrating the Hebbian/anti-Hebbian neural networks into the ASR algorithm, namely, principle subspace projection ASR (PSP-ASR) and principal subspace whitening ASR (PSW-ASR) that segmentwise self-organize the artifact subspace by updating the synaptic weights according to the Hebbian and anti-Hebbian learning rules. The effectiveness of the proposed algorithm is compared to the conventional ASR approaches on benchmark EEG dataset and three BCI frameworks, including steady-state visual evoked potential (SSVEP), rapid serial visual presentation (RSVP), and motor imagery (MI) by evaluating the root-mean-square error (RMSE), the signal-to-noise ratio (SNR), the Pearson correlation, and classification accuracy. The results demonstrated that the PSW-ASR algorithm effectively removed the EEG artifacts and retained the activity-specific brain signals compared to the PSP-ASR, standard ASR (Init-ASR), and moving-window ASR (MW-ASR) methods, thereby enhancing the SSVEP, RSVP, and MI BCI performances. Finally, our empirical results from the PSW-ASR algorithm suggested the choice of an aggressive cutoff range of
${c =}\,\,1$ ${c > }10$ - Published
- 2024
- Full Text
- View/download PDF
8. Intelligent agent for real-world applications on robotic edutainment and humanized co-learning
- Author
-
Lee, Chang-Shing, Wang, Mei-Hui, Tsai, Yi-Lin, Ko, Li-Wei, Tsai, Bo-Yu, Hung, Pi-Hsia, Lin, Lu-An, and Kubota, Naoyuki
- Abstract
Dynamic assessment with an intelligent agent can differentiate the capabilities and proficiency of students. It can therefore be advocated as an interactive approach to conduct assessments on students in learning systems. Facebook AI Research proposed ELF OpenGo, an open-source reimplementation of the AlphaZero algorithm. They also developed Darkforest, which displays the competence and skills of high-level amateur Go players. To enable these open-source AI bots to assist humans at different levels in learning Go, this paper proposes an intelligent agent for real-world applications in robotic edutainment and humanized co-learning. To achieve this, we successfully constructed an OpenGo Darkforest (OGD) cloud platform using these AI bots and further combined the brain computer interface with the OGD cloud platform to observe the relationship between the brainwaves and win rates of human Go players. The intelligent agent also converted human brainwaves into physiological indices and reflected these in the robot to express human feelings or emotions in real-time. For future educational applications, this paper also presents intelligent robot teachers learning together with students in Taiwan and Japan. More than 200 students have been co-learning with intelligent robot teachers in Tainan, Kaohsiung, Taipei, and Tokyo from 2018 to 2019. The learning performance and feedback from students and teachers has been extremely positive, especially from remedial students.
- Published
- 2024
- Full Text
- View/download PDF
9. The Utility of a Novel Neuropsychological Measurement to Analyze Event-Related Attentional Behaviors among Young Children with Attention Deficit Hyperactivity Disorder-a Pilot Study.
- Author
-
Chen IC, Zheng YQ, Zhao HX, Lin LC, Chen YJ, Chang MH, and Ko LW
- Abstract
Objective: The identification and diagnosis of children with attention deficit hyperactivity disorder (ADHD) traits is challenging during the preschool stage. Neuropsychological measures may be useful in early assessments. Furthermore, analysis of event-related behavior appears to be an unmet need for clinical treatment planning. Conners' Kiddie Continuous Performance Test (K-CPT) is the most popular well-established neuropsychological measurement but lacks event markers to clarify the heterogeneous behaviors among children. This study utilized a novel commercially available neuropsychological measure, the ΣCOG, which was more game-like and provided definite event markers of individual trial in the test., Methods: Thirty-three older preschool children (14 were diagnosed with ADHD, mean age: 66.21 ± 5.48 months; 19 demonstrated typical development, mean age: 61.16 ± 8.11 months) were enrolled and underwent comprehensive medical and developmental evaluations. All participants underwent 2 versions of neuropsychological measures, including the K-CPT, Second Edition (K-CPT 2) and the ΣCOG, within a short interval., Results: The study indicated the omissions and response time scores measured in this novel system correlated with clinical measurement of the behavioral scales in all participants and in the group with ADHD; additionally, associations with the traditional K-CPT 2 were observed in commissions and response time scores. Furthermore, this system provided a within-task behavioral analysis that identified the group differences in the specific trial regarding omission and commission errors., Conclusions: This innovative system is clinically feasible and can be further used as an alternative to the K-CPT 2 especially in research by revealing within-task event-related information analysis., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
- Published
- 2024
- Full Text
- View/download PDF
10. Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan.
- Author
-
Hsieh PC, Yu CC, Tzeng IS, Hsieh TH, Wu CF, Ko LF, Lan CC, and Chao YC
- Subjects
- Humans, Male, Female, Middle Aged, Taiwan epidemiology, Retrospective Studies, Aged, COVID-19 Drug Treatment, Fatigue drug therapy, Fatigue etiology, Adult, Medicine, Chinese Traditional methods, Treatment Outcome, Drugs, Chinese Herbal therapeutic use, COVID-19 complications, COVID-19 epidemiology, COVID-19 psychology, SARS-CoV-2
- Abstract
Introduction: An estimated 43% of COVID-19 patients showed sequelae, including fatigue, neurocognitive impairment, respiratory symptoms, and smell or taste disorders. These sequelae significantly affect an individual's health, work capacity, healthcare systems, and socioeconomic aspects. Traditional Chinese herbal medicine (TCHM) management showed clinical benefits in treating patients with COVID-19 sequelae. This study aimed to analyze the effects of personalized TCHM management in patients with COVID-19 sequelae. Methods: After the COVID-19 outbreak in Taiwan, we recorded Chronic Obstructive Pulmonary Disease Assessment Tool (CAT), Chalder Fatigue Questionnaire (CFQ-11), and Brief Symptom Rating Scale (BSRS-5) to assess post-COVID respiratory, fatigue, and emotional distress symptoms, respectively. In this study, we retrospectively reviewed the medical records between July 2022 and March 2023. We analyzed the effects of TCHM administration after 14- and 28-days of treatment. Results: 47 patients were included in this study. The results demonstrated that personalized TCHM treatment significantly improved the CAT, CFQ-11, and BSRS-5 scores after 14 and 28 days. TCHM alleviated physical and psychological fatigue. In logistic regression analysis, there was no statistically significant differences in the severity of the baseline symptoms and TCHM administration effects concerning the duration since the initial confirmation of COVID-19, sex, age, or dietary preference (non-vegetarian or vegetarian). Conclusions: Our study suggested that personalized TCHM treatment notably reduced fatigue, respiratory and emotional distress symptoms after 14- and 28-days of treatment in patients with COVID-19 sequelae. We propose that TCHM should be considered as an effective intervention for patients with COVID-19 sequelae., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)
- Published
- 2024
- Full Text
- View/download PDF
11. Exploring Embodied Cognition and Brain Dynamics Under Multi-Tasks Target Detection in Immerse Projector-Based Augmented Reality (IPAR) Scenarios.
- Author
-
He C, Chen YY, Phang CR, Chen IP, Tzou SC, Jung TP, and Ko LW
- Subjects
- Humans, Male, Female, Adult, Young Adult, Brain physiology, Multitasking Behavior physiology, Standing Position, Wireless Technology, Attention physiology, Healthy Volunteers, Theta Rhythm physiology, Beta Rhythm physiology, Brain-Computer Interfaces, Electroencephalography, Cognition physiology, Augmented Reality, Walking physiology
- Abstract
Embodied cognition explores the intricate interaction between the brain, body, and the surrounding environment. The advancement of mobile devices, such as immersive interactive computing and wireless electroencephalogram (EEG) devices, has presented new challenges and opportunities for studying embodied cognition. To address how mobile technology within immersive hybrid settings affects embodied cognition, we propose a target detection multitask incorporating mixed body movement interference and an environmental distraction light signal. We aim to investigate human embodied cognition in immersive projector-based augmented reality (IPAR) scenarios using wireless EEG technology. We recruited and engaged fifteen participants in four multitasking conditions: standing without distraction (SND), walking without distraction (WND), standing with distraction (SD), and walking with distraction (WD). We pre-processed the EEG data using Independent Component Analysis (ICA) to isolate brain sources and K-means clustering to categorize Independent Components (ICs). Following that, we conducted time-frequency and correlation analyses to identify neural dynamics changes associated with multitasking. Our findings reveal a decline in behavioral performance during multitasking activities. We also observed decreases in alpha and beta power in the frontal and motor cortex during standing target search tasks, decreases in theta power, and increases in alpha power in the occipital lobe during multitasking. We also noted perturbations in theta band power during distraction tasks. Notably, physical movement induced more significant fluctuations in the frontal and motor cortex than distractions from social environment light signals. Particularly in scenarios involving walking and multitasking, there was a noticeable reduction in beta suppression. Our study underscores the importance of brain-body collaboration in multitasking scenarios, where the simultaneous engagement of the body and brain in complex tasks highlights the dynamic nature of cognitive processes within the framework of embodied cognition. Furthermore, integrating immersive augmented reality technology into embodied cognition research enhances our understanding of the interplay between the body, environment, and cognitive functions, with profound implications for advancing human-computer interaction and elucidating cognitive dynamics in multitasking.
- Published
- 2024
- Full Text
- View/download PDF
12. Accurate Mental Stress Detection Using Sequential Backward Selection and Adaptive Synthetic Methods.
- Author
-
Tseng HC, Tai KY, Ma YZ, Van LD, Ko LW, and Jung TP
- Subjects
- Humans, Male, Female, Young Adult, Adult, Reproducibility of Results, Delta Rhythm physiology, Longitudinal Studies, Theta Rhythm physiology, Stress, Psychological diagnosis, Stress, Psychological physiopathology, Electroencephalography methods, Algorithms
- Abstract
The daily experience of mental stress profoundly influences our health and work performance while concurrently triggering alterations in brain electrical activity. Electroencephalogram (EEG) is a widely adopted method for assessing cognitive and affective states. This study delves into the EEG correlates of stress and the potential use of resting EEG in evaluating stress levels. Over 13 weeks, our longitudinal study focuses on the real-life experiences of college students, collecting data from each of the 18 participants across multiple days in classroom settings. To tackle the complexity arising from the multitude of EEG features and the imbalance in data samples across stress levels, we use the sequential backward selection (SBS) method for feature selection and the adaptive synthetic (ADASYN) sampling algorithm for imbalanced data. Our findings unveil that delta and theta features account for approximately 50% of the selected features through the SBS process. In leave-one-out (LOO) cross-validation, the combination of band power and pair-wise coherence (COH) achieves a maximum balanced accuracy of 94.8% in stress-level detection for the above daily stress dataset. Notably, using ADASYN and borderline synthesized minority over-sampling technique (borderline-SMOTE) methods enhances model accuracy compared to the traditional SMOTE approach. These results provide valuable insights into using EEG signals for assessing stress levels in real-life scenarios, shedding light on potential strategies for managing stress more effectively.
- Published
- 2024
- Full Text
- View/download PDF
13. Decoding Human Somatosensory Sensitivity Through Resting EEG and Behavioral Analysis: A Multimodal Fusion Approach.
- Author
-
Lin HY, He C, Su CH, Hope Pan LL, Hsiao FJ, Wu YT, Wang YF, Wang SJ, and Ko LW
- Subjects
- Humans, Male, Female, Adult, Young Adult, Healthy Volunteers, Support Vector Machine, Rest physiology, Somatosensory Cortex physiology, Cold Temperature, Hot Temperature, Electroencephalography methods, Algorithms
- Abstract
In precision medicine and clinical pain management, the creation of quantitative, objective indicators to assess somatosensory sensitivity was essential. This study proposed a fusion approach for decoding human somatosensory sensitivity, which combined multimodal (quantitative sensory test and neurophysiology) features to classify the dataset on individual somatosensory sensitivity and reveal distinct types of brain activation patterns. Sixty healthy participants took part in the experiment on somatosensory sensitivity that implemented cold, heat, mechanical punctate, and pressure stimuli, and the resting-state electroencephalography (EEG) was collected using BrainVision. The quantitative sensory testing (QST) scores of the participants were clustered using the unsupervised k-means algorithm into four subgroups: generally hypersensitive (HS), generally non-sensitive (NS), predominantly thermally sensitive (TS), and predominantly mechanically sensitive (MS). Furthermore, two types of power spectral density (PSD), band-based PSD (BB-PSD) and frequency-based PSD (FB-PSD), and two types of inter-electrode connectivity (IEC), band-based connectivity (BBC) and frequency-based connectivity (FBC), derived from resting-state EEG were subjected to feature selection with a proposed prior-compared minimum-redundancy maximum-relevance (PCMRMR) protocol. Their effectiveness was then tested by the supervised classification tasks using support vector machine (SVM), k-nearest neighbor (kNN), random forest (RF), and Gaussian classifier (GC). Brain networks of four somatosensory types were revealed by decoding fused multimodal data, namely type-averaged connectivity. The data from sixty healthy individuals were divided into training (n =59) and validation (n =1) datasets according to leave-one-subject-out (LOSO) criteria. The FBC was identified, which can serve as better brain signatures than BB-PSD, FB-PSD, and BBC to classify subjects as HS, NS, TS, or MS groups. Using the SVM, kNN, RF, and GC models, the best accuracy of 87% was obtained when classifying participants into HS, NS, TS, or MS groups. Moreover, the brain networks were decoded from HS, NS, TS, and MS groups by decoding the type-averaged connectivity fused from somatosensory phenotypes and selected FBC. It indicated that quantified multi-parameter somatosensory sensitivity could be achieved with acceptable accuracy, leading to considerable possibilities for using objective pain perception evaluation in clinical practice.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.