1. Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024.
- Author
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Sun W, Choy KT, Cheng KM, Brackman CJ, Cheng SM, Sit TH, Tse AC, Sims LD, Gu H, Tang AW, Wong AN, Tsang AT, Koo JC, Luk LL, Yen HL, Peris M, and Poon LL
- Subjects
- Animals, Humans, Mice, Hong Kong epidemiology, Genotype, Phylogeny, Virulence, Animals, Wild virology, China epidemiology, Antibodies, Neutralizing blood, Antiviral Agents therapeutic use, Antiviral Agents pharmacology, Influenza in Birds virology, Influenza in Birds epidemiology, Influenza A Virus, H5N1 Subtype genetics, Influenza A Virus, H5N1 Subtype pathogenicity, Influenza A Virus, H5N1 Subtype isolation & purification, Birds virology, Influenza A Virus, H5N8 Subtype genetics, Influenza A Virus, H5N8 Subtype pathogenicity, Influenza A Virus, H5N8 Subtype isolation & purification, Influenza, Human virology, Influenza, Human epidemiology
- Abstract
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021-2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.
- Published
- 2025
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