1. Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders.
- Author
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Aghdassi, Ali A., Pham, Christine, Zierke, Lukas, Mariaule, Vincent, Korkmaz, Brice, and Rhimi, Moez
- Subjects
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ELASTASES , *PROTEINASES , *CELL physiology , *PROTEOLYTIC enzymes , *LEUCOCYTE elastase , *ACUTE diseases , *PEPTIDASE , *SERINE proteinases - Abstract
Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase expressed in several tissues including inflammatory cells. This enzyme is important for maintaining multiple cellular functions and for processing immune cell-derived proteases. While mutations in the CatC gene were reported in Papillon-Lefèvre syndrome, a rare autosomal recessive disorder featuring hyperkeratosis and periodontitis, evidence from clinical and preclinical studies points toward pro-inflammatory effects of CatC in various disease processes that are mainly mediated by the activation of neutrophil serine proteinases. Moreover, tumor-promoting effects were ascribed to CatC. The aim of this review is to highlight current knowledge of the CatC as a potential therapeutic target in inflammatory disorders. [Display omitted] • Cathepsin C activates granule serine proteinases involved in inflammation. • Cathepsin C contributes to the pathogenesis of different acute and chronic diseases. • Potential of cathepsin C inhibition to ameliorate inflammation in preclinical models. • Need for studies evaluating CatC inhibitors repurposing in chronic inflammatory diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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