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Introduction: Migraine is a common neurological disorder with no exact pathophysiology. In recent years, studies from the perspective of "Gut-Brain Axis" hypothesis have shown a strong connection between how the Gut and the Brain affect each other in different types of mechanisms such as but not limited to hormones, metabolites, and neuroendocrine factors. From that perspective, there are no studies examining migraine's connection to gut permeability. To examine the aforementioned permeability, two proteins (lipopolysaccharide binding protein and zonulin) were selected. Method: In this particular study, migraine patients (n=52) blood samples were collected at the Neurology Clinic at Bezmialem Vakıf University. The patient group was categorized according to aura history, visual analogue scale (VAS) value, migraine attack frequency per month, onset time, photophobia, sonophobia, pain duration per attack, and nausea and vomiting symptoms. Samples were studied with ELISA Kits at the Biochemistry Laboratory located in Bezmialem University. Their results were compared to healthy controls (n=30) later. Results: There were no significant differences detected between migraine and healthy control groups in the mean serum zonulin and LPBP levels (p>0.05). However, we found a moderately significant correlation between VAS values for both our parameters (p=0.03 for zonulin and p=0.02 for LPBP). Conclusion: Our group could not show a significant connection between migraine and gut permeability directly; however, as our results suggest a moderate significance between pain intensity and zonulin and LPBP levels, further studies are needed to elaborate the subject. [ABSTRACT FROM AUTHOR]