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HD 209458 b is one of the most studied exoplanets to date. Despite this, atmospheric characterisation studies yielded inconsistent species detections and abundances. Values reported for the C/O ratio range from 0.1 to 1.0. Of particular interest is the simultaneous detection of H2O and HCN reported by some studies using high-resolution ground-based observations, which would require the atmospheric C/O ratio to be fine-tuned to a narrow interval around 1. HCN has however not been detected from recent space-based observations. We aim to provide an independent study of HD 209458 b's atmosphere with high-resolution observations, in order to infer the presence of several species, including H2O and HCN. We observed four primary transits of HD 209458 b at a high resolution (R=92000) with CRIRES+ in the near infrared (band H, 1.4--1.8 um). After reducing the data with pycrires, we prepared the data using the SysRem algorithm and performed a cross-correlation (CCF) analysis of the transmission spectra. We also compared the results with those obtained from simulated datasets constructed by combining the Exo-REM self-consistent model with the petitRADTRANS package. Combining the four transits, we detect H2O with a signal-to-noise CCF metric of 8.7. This corresponds to a signal emitted at $K_p=151.3^{+31.1}_{-23.4}$ km/s and blueshifted by $-6^{+1}_{-2}$ km/s, consistent with what is expected for HD 209458 b. We do not detect any other species among C2H2, CH4, CO, CO2, H2S, HCN, and NH3. Comparing this with our simulated datasets, this result is consistent with a C/O ratio of 0.1 and an opaque cloud top pressure of 50 Pa, at a 3 times solar metallicity. This would also be consistent with recent JWST observations. However, none of the simulated results obtained with a bulk C/O ratio of 0.8, a value suggested by previous studies using GIANO-B and CRIRES, are consistent with our observations., Comment: 15 pages, 13 figures, 5 tables, accepted for publication in Astronomy & Astrophysics

Young brown dwarfs exhibit atmospheric characteristics similar to those of super-Jupiters, providing a unique opportunity to study planetary atmospheres. The ESO SupJup Survey, utilizing CRIRES$^+$ on the Very Large Telescope, aims to assess the role of $^{12}$C/$^{13}$C as a formation tracer. We present observations of three young brown dwarfs: 2MASS J12003792-7845082, TWA 28, and 2MASS J08561384-1342242, with the goal of constraining their chemical compositions, thermal profiles, surface gravities, spin rotations, and $^{12}$C/$^{13}$C. Atmospheric retrievals of CRIRES$^+$ K-band spectra were conducted using the radiative transfer code petitRADTRANS coupled with the Bayesian inference algorithm MultiNest, resulting in a detailed characterization of the atmospheres of these objects. We report the volume mixing ratios of main molecular and atomic species, including the novel detection of hydrogen fluoride (HF) in a brown dwarf's atmosphere, and determine $^{12}$C/$^{13}$C values of $81^{+28}_{-19}$ and $79^{+20}_{-14}$ in the atmospheres of TWA 28 and J0856, respectively, with strong significance ($>3\sigma$). Tentative evidence ($\sim 2\sigma$) of $^{13}$C in J1200 was found, with $^{12}$C/$^{13}$C = $114^{+69}_{-33}$, along with $^{18}$O detected at moderate significance in J0856 (3.3$\sigma$) and TWA 28 (2.1$\sigma$). The retrieved thermal profiles indicate hot atmospheres (2300-2600 K) with low surface gravities and slow spins, consistent with young objects. The consistent carbon isotope ratios among the three objects, showing no significant deviation from the local ISM, suggest a fragmentation-based formation mechanism similar to star formation. The tentative detection of $^{18}$O in two objects highlights the potential of high-resolution spectroscopy to probe additional isotope ratios, such as $^{16}$O/$^{18}$O, in the atmospheres of brown dwarfs and super-Jupiters., Comment: Published in A&A Volume 689, September 2024

It has been proposed that the distinct formation and evolution of exoplanets and brown dwarfs may affect the chemical and isotopic content of their atmospheres. Recent work has indeed shown differences in the $^{12}$C/$^{13}$C isotope ratio, provisionally attributed to the top-down formation of brown dwarfs and the core accretion pathway of super-Jupiters. The ESO SupJup Survey aims to disentangle the formation pathways of isolated brown dwarfs and planetary-mass companions using chemical and isotopic tracers. The survey uses high-resolution spectroscopy with the recently upgraded VLT/CRIRES$^+$ spectrograph, covering a total of 49 targets. Here, we present the first results: an atmospheric characterisation of DENIS J0255-4700, an isolated brown dwarf near the L-T transition. We analyse its K-band spectrum using a retrieval framework where the radiative transfer code petitRADTRANS is coupled to PyMultiNest. Gaussian Processes are employed to model inter-pixel correlations and we adopt an updated parameterisation of the PT-profile. Abundances of CO, H$_2$O, CH$_4$, and NH$_3$ are retrieved for this fast-rotating L-dwarf. The ExoMol H$_2$O line list provides a significantly better fit than that of HITEMP. A free-chemistry retrieval is strongly favoured over equilibrium chemistry, caused by an under-abundance of CH$_4$. The free-chemistry retrieval constrains a super-solar C/O-ratio of $\sim0.68$ and a solar metallicity. We find tentative evidence ($\sim3\sigma$) for the presence of $^{13}$CO, with a constraint on the isotope ratio of $\mathrm{^{12}C/^{13}C}=184^{+61}_{-40}$ and a lower limit of $\gtrsim97$, suggesting a depletion of $^{13}$C compared to the interstellar medium ($\sim68$). High-resolution, high signal-to-noise K-band spectra provide an excellent means to constrain the chemistry and isotopic content of sub-stellar objects, as is the main objective of the ESO SupJup Survey., Comment: Submitted to A&A

Objectives: The generation of structured documents for clinical trials is a promising application of large language models (LLMs). We share opportunities, insights, and challenges from a competitive challenge that used LLMs for automating clinical trial documentation., Materials and Methods: As part of a challenge initiated by Pfizer (organizer), several teams (participant) created a pilot for generating summaries of safety tables for clinical study reports (CSRs). Our evaluation framework used automated metrics and expert reviews to assess the quality of AI-generated documents., Results: The comparative analysis revealed differences in performance across solutions, particularly in factual accuracy and lean writing. Most participants employed prompt engineering with generative pre-trained transformer (GPT) models., Discussion: We discuss areas for improvement, including better ingestion of tables, addition of context and fine-tuning., Conclusion: The challenge results demonstrate the potential of LLMs in automating table summarization in CSRs while also revealing the importance of human involvement and continued research to optimize this technology., Competing Interests: All authors are employees and shareholders of Pfizer Inc., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association.)