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Aim: The distinctive feature of corneal dystrophies is the existence of abnormal deposits that are insoluble and found in different layers of the cornea. While corneal thickness has been investigated in corneal stromal dystrophies, anterior scleral thickness has not yet been evaluated. We aimed to investigate anterior scleral thickness and corneal and anterior segment parameters in corneal stromal dystrophies in this study. Materials and Methods: The study was conducted with 35 eyes with corneal stromal dystrophies from 19 patients and 35 healthy controls. We calculated the anterior scleral thickness 4 mm posterior to the scleral spur in the nasal and temporal quadrants, by anterior segment optic coherence tomography (Triton, Topcon, Japan). Scheimflug corneal tomography (Sirius, CSO, Italy) was performed to assess corneal and anterior segment parameters. Results: The mean age was 36.5±12.1 years in the dystrophy group. The mean temporal scleral thickness was 556.67±15.11 µm, and the mean nasal scleral thickness was 565.83±15.18 µm, statistically similar to those of the control group (p=0.81, p=0.51, respectively). However, the difference between temporal and nasal scleral thickness values was not statistically significant in the dystrophy group (p=0.53, p=0.57). Intraocular pressure was higher in lattice stromal dystrophy than in other dystrophies (p=0.005). There was found to be a moderate, positive correlation between age and nasal scleral thickness in the control group. (r=0.432; p=0.010). Conclusion: In conclusion, we found that scleral thickness did not change in corneal dystrophies. Further histological studies are needed to conclusively exclude microstructural alterations of scleral thickness in patients with corneal stromal dystrophies. [ABSTRACT FROM AUTHOR]

Purpose: To provide a brief summary and comparison of the most recent literature on available and theorized treatment modalities for classic lattice corneal dystrophy (LCD). This paper aims to support practitioners in their management of this disease. Methods: A search was carried out on available literature through PubMed and Google Scholar of English language articles up to January 2023 that relate to the treatment of LCD. Due to scarcity of literature regarding specific novel therapies for LCD, results from other corneal pathologies (granular corneal dystrophy, corneal scarring) are sometimes included for contrast, which is clearly denoted. Results: LCD is a slowly progressive disease that leads to recurrent epithelial corneal erosions, stromal haze, corneal opacification, substantial discomfort, and visual impairment. Due to its autosomal-dominant inheritance pattern, this disease can persist throughout ancestral lines and requires consistent treatment and follow-up. An optimal management plan is necessary to (1) prolong years of life with best achievable visual acuity; (2) treat painful recurrent corneal erosions as they occur; (3) ensure proper follow-up throughout the life of a patient, as well as monitor at-risk offspring; and (4) monitor efficacy of treatment. Conclusions: This paper addresses (1) treatment for early disease including corneal epithelial debridement, photo therapeutic keratectomy (PTK), femtosecond laser–assisted lamellar keratectomy (FLK), and others; (2) treatment for late disease including full thickness keratoplasties and anterior lamellar keratoplasties; and (3) potential future treatment considerations including a wide variety of topical/systemic, genetic, and regenerative approaches. [ABSTRACT FROM AUTHOR]