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Reduced N input while maintaining biomass production of sorghum × sudangrass hybrids (Sorghum bicolor L. × Sorghum sudanense; SSG) is essential; however, its effects on root sustainability and photosynthetic capacity during the ratooning period are not well defined in a multiple harvests system. The physiological response and root morphology of SSG were investigated under different N application levels during the ratooning period in a two-year field experiment. Treatments were all combinations of two ecotypes (late-flowering, Greenstar; early-flowering, Honeychew) and four N levels (0, 50, 100, 150 kg N ha−1). The total root length, surface area, volume, tips, and dry matter (DM) were significantly influenced by both ecotype and N level, with Greenstar outperforming Honeychew. Specifically, Greenstar's root length increased by up to three times with reduced N application (50 kg N ha−1), while Honeychew showed significant root length increases only at higher N levels (100 and 150 kg N ha−1). Our data support the conclusion that a low level of N (50–100 kg N ha−1) was the optimal rate for ratooning root sustainability. The findings highlight the critical role of root development in sustaining biomass production and suggest that the late-flowering ecotype, Greenstar, is more suitable for a multiple harvests system with a robust root system. [ABSTRACT FROM AUTHOR]

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin and internal organ fibrosis and obliterative vasculopathy. Few effective treatments are currently available for fibrosis in SSc, therefore, demand persists for novel therapies. Although use of Ginkgo biloba extract (GBE) has been reported to improve blood circulation and alleviate liver and lung fibrosis, its effect on skin fibrosis in SSc remains unclear. In this study, the effects and underlying mechanisms of GBE on skin fibrosis in bleomycin (BLM)-induced mouse model of SSc was investigated. GBE significantly reduced dermal thickness and protein levels of profibrotic factors in the BLM-induced SSc mouse model. Moreover, GBE inhibited the gene expression of profibrotic factors, such as COL1A1, α-SMA, and connective tissue growth factor (CTGF), in fibroblasts by suppressing transforming growth factor (TGF)-β signaling. Furthermore, GBE inhibited the transdifferentiation of adipocytes into myofibroblasts. Thus, our findings suggest that GBE is a promising therapeutic candidate for the treatment of SSc., Competing Interests: No potential conflict of interest was reported by the author(s)., (© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)