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This paper aims to investigate history, analyze concrete cases, and provide an in-depth look at whether and how women can play leadership roles in the Church. The method used in this research is a literature study. The case study method was also used with Sr Ann Rose Nu Tawng from Myanmar as the subject. The important result of this research is that women's leadership in the Church has a very vital function. In fact, women's leadership has various characteristics and advantages that cannot be replaced by men. Church history has proven that. Finally, the conclusion of this paper is that women should be given more opportunities and trust to take on leadership roles in the Church for the good of the Church itself.

Abstract Kitaev chains in quantum dot-superconductor arrays are a promising platform for the realization of topological superconductivity. As recently demonstrated, even a two-site chain can host Majorana zero modes known as “poor man’s Majorana”. Harnessing the potential of these states for quantum information processing, however, requires increasing their robustness to external perturbations. Here, we form a two-site Kitaev chain using Yu-Shiba-Rusinov states in proximitized quantum dots. By deterministically tuning the hybridization between the quantum dots and the superconductor, we observe poor man’s Majorana states with a gap larger than 70 μeV. The sensitivity to charge fluctuations is also greatly reduced compared to Kitaev chains made with non-proximitized dots. The systematic control and improved energy scales of poor man’s Majorana states realized with Yu-Shiba-Rusinov states will benefit the realization of longer Kitaev chains, parity qubits, and the demonstration of non-Abelian physics.

Abstract Aims Despite half of all heart failure patients suffering from heart failure with preserved ejection fraction (HFpEF), treatment options are limited. This study aims to compare safety and efficacy of standard pacemaker programming (DDD or DDDR) and a novel pacing algorithm PressurePace™ (BaroPace Inc, Issaquah, WA, USA) which modulates atrial pacing rate based on blood pressure (BPAP). Methods This prospective, randomized, double‐blind, non‐significant risk proof of concept study was conducted at two large cardiology clinics in Los Angeles, California, USA. Subjects underwent two modified Bruce protocol graded treadmill exercise tests in which pacemaker programming was randomized to either standard programming (DDD or DDDR), or BPAP at least 1 week apart. Physiological measurements of heart rate (HR), and systolic and diastolic blood pressure (BP) were collected at 2 min intervals. During the BPAP treadmill test, the pacemaker activity sensor was disabled. The PressurePace algorithm instructed the pacemaker technician to modify or leave unchanged the atrial pacing rate based on these BP measurements. Subjects and clinical staff were blinded to pacemaker programming, only the pacemaker technician was unblinded. Results Ten subjects with HFpEF associated with hypertension who also had permanent dual‐chamber pacemakers, previously implanted for standard clinical indications, participated in the study. Mean age was 70.1 ± 6.8 years, left ventricular ejection fraction of 54.8 ± 1.9%. Exercise duration increased in all 10 subjects, when paced in the BPAP mode compared with standard pacemaker programming, showing a mean increase of 117 s (26%, P = 0.0016). The algorithm could adjust HR at each 2 min interval. The majority of subjects (60%) had their atrial pacing rate increased an average of 20% at t = 2 min. In the remaining 40% of subjects, the algorithm instructed HR to be unchanged. In two subjects, the pacing rate was not increased until t = 6 min. In contrast, subjects programmed to DDDR experienced an average of 45% increase in atrial pacing rate at t = 2 min. In the post‐treadmill recovery period, SBP was higher for subjects who underwent BPAP. This difference in SBP was most pronounced immediately post‐treadmill and diminished as subjects progressed through the 30 min recovery period. Statistical significance was achieved at t = 0, 20, and 30 min post‐treadmill. Conclusions An increase in exercise duration was reported in HFpEF subjects using a pacing algorithm that modulated HR based on BP compared with standard programming. These encouraging results form the basis for a larger, randomized cross‐over trial to confirm these initial observations, further characterize the safety, efficacy, and possible mechanisms of action in both acute and longer‐term treatment.

Abstract Rock strength is imperative for the design and stability analysis of engineering structures. The Mohr–Coulomb (M-C) criterion holds significant prominence in geotechnical engineering. However, the M-C criterion fails to accurately capture the nonlinear strength response and neglects the critical state of rocks, potentially leading to inaccuracies in the design phase of deep engineering projects. This study introduces an innovative stress-dependent friction angle and cohesion (SFC) for the M-C criterion to capture the nonlinear strength responses of intact rocks, spanning from non-critical to critical states (brittle to ductile regions). A novel method for determining these stress-dependent parameters at each corresponding $$\sigma_{3}$$ σ 3 is initially introduced. Subsequently, an examination of the confinement dependency of the friction angle and cohesion is conducted, leading to the derivation of the SFC model. The SFC-enhanced M-C criterion, utilizing parameters obtained from triaxial tests under lower $$\sigma_{3}$$ σ 3 , demonstrates the capability to delineate the complete non-linear strength envelope from brittle to ductile regions. Validation through triaxial test data confirms that the predictions of the SFC-enhanced M-C criterion accurately correspond to the strength characteristics of the tested rocks.

Abstract Current therapies for high-grade TP53-mutated myeloid neoplasms (≥10% blasts) do not offer a meaningful survival benefit except allogeneic stem cell transplantation in the minority who achieve a complete response to first line therapy (CR1). To identify reliable pre-therapy predictors of complete response to first-line therapy (CR1) and outcomes, we assembled a cohort of 242 individuals with TP53-mutated myeloid neoplasms and ≥10% blasts with well-annotated clinical, molecular and pathology data. Key outcomes examined were CR1 & 24-month survival (OS24). In this elderly cohort (median age 68.2 years) with 74.0% receiving frontline non-intensive regimens (hypomethylating agents +/- venetoclax), the overall cohort CR1 rate was 25.6% (50/195). We additionally identified several pre-therapy factors predictive of inferior CR1 including male gender (P = 0.026), ≥2 autosomal monosomies (P 25% (P = 0.002), TP53 splice junction mutations (P = 0.007) and antecedent treated myeloid neoplasm (P = 0.001). In addition, mutations/deletions in CUX1, U2AF1, EZH2, TET2, CBL, or KRAS (‘EPI6’ signature) predicted inferior OS24 (HR = 2.0 [1.5–2.8]; P

Underground constructions often encounter water environments, where water–rock interaction can increase porosity, thereby weakening engineering rocks. Correspondingly, the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such structures. This study enhances the applicability of the Hoek-Brown (H-B) criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi (KPIM). A multiscale experimental investigation, including nuclear magnetic resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), pH and ion chromatography analysis, and triaxial compression tests, is employed to quantify pore structural changes and their linkage with the strength responses of limestone under coupled chemical-mechanical (C-M) conditions. By employing ion chromatography and NMR analysis, along with incorporating the principles of free-face dissolution theory accounting for both congruent and incongruent dissolution, a kinetic chemical corrosion model is developed. This model aims to calculate the kinetic porosity alterations within rocks exposed to varying H+ concentrations and durations. Subsequently, utilizing the generalized mixture rule (GMR), the kinetic porosity-dependent mi is formulated. Evaluation of the KPIM-enhanced H-B criterion using compression test data from 5 types of rocks demonstrated a high level of consistency between the criterion and the experimental results, with a coefficient of determination greater than 0.96, a mean absolute percentage error less than 4.84%, and a root-mean-square deviation less than 5.95 MPa. Finally, the physical significance of the porosity-dependent instantaneous mi is clarified: it serves as an indicator of a rock’s capacity to leverage the confining pressure effect.

Abstract Background Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both stem cell renewal and differentiation. However, responses to HA in culture are influenced by interaction with a range of cognate factors and receptors including components of blood serum supplements, which alter results. These may contribute to variation in cell batch production yield and phenotype as well as heighten the risks of adventitious pathogen transmission in the course of cell processing for therapeutic applications. Main Here we characterise differentiation of a human embryo/pluripotent stem cell derived Mesenchymal Stromal Cell (hESC/PSC-MSC)-like cell population by culture on a planar surface coated with HA in serum-free media qualified for cell production for therapy. Resulting cells met minimum criteria of the International Society for Cellular Therapy for identification as MSC by expression of. CD90, CD73, CD105, and lack of expression for CD34, CD45, CD14 and HLA-II. They were positive for other MSC associated markers (i.e.CD166, CD56, CD44, HLA 1-A) whilst negative for others (e.g. CD271, CD71, CD146). In vitro co-culture assessment of MSC associated functionality confirmed support of growth of hematopoietic progenitors and inhibition of mitogen activated proliferation of lymphocytes from umbilical cord and adult peripheral blood mononuclear cells, respectively. Co-culture with immortalized THP-1 monocyte derived macrophages (Mɸ) concurrently stimulated with lipopolysaccharide as a pro-inflammatory stimulus, resulted in a dose dependent increase in pro-inflammatory IL6 but negligible effect on TNFα. To further investigate these functionalities, a bulk cell RNA sequence comparison with adult human bone marrow derived MSC and hESC substantiated a distinctive genetic signature more proximate to the former. Conclusion Cultivation of human pluripotent stem cells on a planar substrate of HA in serum-free culture media systems is sufficient to yield a distinctive developmental mesenchymal stromal cell lineage with potential to modify the function of haematopoietic lineages in therapeutic applications.

Background: The combination of an inhaled corticosteroid (ICS) and long-acting β-agonist (LABA) (ICS/LABA) has shown superiority in improving lung function (FEV1) compared with an ICS alone. The clinical effect of a ICS/LABA combination depends on the fine-particle fraction and the pulmonary deposition. Objective: We sought to compare the efficacy of 2 combinations of an ICS and LABA, namely, fluticasone propionate (FP) and formoterol (FORM) (FP/FORM) and fluticasone furoate (FF) and vilanterol (VI) (FF/VI), in asthmatic adolescents with chronic bronchial obstruction. Methods: FP/FORM (125 μg/5 μg, 2 doses twice daily via the k-haler [Mundipharma, Cambridge, UK]) and FF/VI (92 μg/22 μg, once daily via the Ellipta inhaler [GlaxoSmithKline]) were administered to adolescents aged 12 to 17 years who required regular antiasthmatic medication and had a ratio of FEV1 to forced vital capacity (FEV1/FVC) less than –1.65 SD in a 2-sequence, 16-week crossover trial. The primary efficacy end point was change in FEV1 compared with baseline. Secondary end points were FEV1/FVC ratio, maximal expiratory flow at 50% of the FVC, impulse oscillometry indices respiratory resistance at 5 Hz (R5), difference between R5 and respiratory resistance at 20 Hz (R20), area of reactance, and Asthma Control Test score. Results: Both ICS/LABA combinations resulted in a significant improvement in FEV1 and maximal expiratory flow at 50% of the FVC z scores without any significant difference between FP/FORM and FF/VI, with 40% of patients with either treatment achieving a normal prebronchodilator FEV1/FVC z score. Neither area of reactance nor difference between R5 and R20 improved significantly with either treatment. Conclusion: Both ICS/LABA combinations demonstrated significant improvements in FEV1 z score. More than one-third of the asthmatic adolescents with prolonged bronchial obstruction achieved a normal prebronchodilator FEV1/FVC ratio.

Abstract Inertial electrostatic confinement fusion (IECF) devices often use two concentric spherical electrodes to converge ions in a plasma electrostatically. Using a highly transparent inner cathode, the ions can move through the cathode and collide at the center to undergo fusion reactions. This is a simple method to build a neutron source. Past research has focused chiefly on cathode “grids” manufactured by joining metal wire loops or disc-shaped elements via spot welding. There are two common geometries: “Globe” grids with a distinct latitude-longitude structure and “symmetric” grids with even-sized triangular-shaped apertures. Recent advances in additive manufacturing have opened the way to manufacturing a third class of grids in which the apertures are evenly distributed over the grid surface and have either circular or polygonal shaped apertures - here called “regular” grids. These three types are analyzed and compared based on a set of metrics, including transparency, homogeneity of aperture size, and the regularity of aperture distribution. It is shown that every type of grid comes with different advantages and disadvantages. The analysis focuses on grid geometries with 6 to 120 apertures.

The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans. This study proposes a theory that expands insulin’s role beyond traditional metabolic functions, incorporating it into the Mitochondrial Information Processing System (MIPS) and exploring it from an evolutionary medicine perspective to explore its function in processing psychological and social factors into biological responses. This narrative review comprises data from preclinical animal studies, longitudinal cohort studies, cross-sectional studies, machine learning analyses, and randomized controlled trials, and investigates the role of insulin in health and disease. The result is a proposal for a theoretical framework of insulin as a social substance within the socio-psycho-biological framework, emphasizing its extensive roles in health and disease. Type 2 Diabetes Mellitus (T2DM) with musculoskeletal disorders and neurodegeneration exemplifies this narrative. We suggest further research towards a comprehensive treatment protocol meeting evolutionary expectations, where incorporating psychosocial interventions plays an essential role. By supporting the concept of ‘insulin resilience’ and suggesting the use of heart rate variability to assess insulin resilience, we aim to provide an integrative approach to managing insulin levels and monitoring the effectiveness of interventions. This integrative strategy addresses broader socio-psychological factors, ultimately improving health outcomes for individuals with T2DM and musculoskeletal complications and neurodegeneration while providing new insights into the interplay between socio-psychological factors and biological systems in chronic diseases.

Background and aims Peroral endoscopic myotomy (POEM) is a standard treatment option for achalasia patients. Treatment response varies due to factors such as achalasia type, degree of dilatation, pressure and distensibility indices. We present an innovative approach for treatment response prediction based on an automatic three-dimensional (3-D) reconstruction of the tubular oesophagus (TE) and the lower oesophageal sphincter (LES) in patients undergoing POEM for achalasia.Methods A software was developed, integrating data from high-resolution manometry, timed barium oesophagogram and endoscopic images to automatically generate 3-D reconstructions of the TE and LES. Novel normative indices for TE (volume×pressure) and LES (volume/pressure) were automatically integrated, facilitating pre-POEM and post-POEM comparisons. Treatment response was evaluated by changes in volumetric and pressure indices for the TE and the LES before as well as 3 and 12 months after POEM. In addition, these values were compared with normal value indices of non-achalasia patients.Results 50 treatment-naive achalasia patients were enrolled prospectively. The mean TE index decreased significantly (p

Coarse measures of socioeconomic status, such as parental income or parental education, have been linked to differences in white matter development. However, these measures do not provide insight into specific aspects of an individual’s environment and how they relate to brain development. On the other hand, educational intervention studies have shown that changes in an individual’s educational context can drive measurable changes in their white matter. These studies, however, rarely consider socioeconomic factors in their results. In the present study, we examined the unique relationship between educational opportunity and white matter development, when controlling other known socioeconomic factors. To explore this question, we leveraged the rich demographic and neuroimaging data available in the ABCD study, as well the unique data-crosswalk between ABCD and the Stanford Education Data Archive (SEDA). We find that educational opportunity is related to accelerated white matter development, even when accounting for other socioeconomic factors, and that this relationship is most pronounced in white matter tracts associated with academic skills. These results suggest that the school a child attends has a measurable relationship with brain development for years to come.

Abstract Identifying the most important factors affecting population growth in animal life cycles is an important tool of species conservation. Delta Smelt (Hypomesus transpacificus), an annual fish endemic to the San Francisco Estuary in California (USA), has been provided legal protection since 1993 but 30 years later exists in a conservation‐reliant state on the brink of extinction. Despite considerable controversies about what factors are most responsible for the species' decline, no population growth rate sensitivity comparisons between the most important factors regulating growth have been done. Nor has anyone attempted to quantitatively identify habitat conditions needed to support positive population growth. We developed a set of stage‐structured population models to link habitat indices regulating recruitment of new generations of fish as they metamorphosed into juveniles and the subsequent survival of those fish over several seasons until they reached adulthood. These models are used to quantify drivers of growth rate variation over 30 years. Several complimentary sensitivity analyses indicated freshwater outflow to the estuary during summer had the largest potential to change population growth. Multiple habitat metrics (e.g., food availability, temperature) influencing recruitment and life stage specific survival rates across different seasons interacted in nonlinear ways to determine habitat conditions and water management targets associated with positive population growth. We discuss the implications for freshwater management, Delta Smelt conservation, and the challenges climate change poses for co‐implementation of these two societal priorities.

Background:Women’s football has been booming for a few years now, which has led to an increase in the expectation of the players’ performance, leading to a more detailed study of women’s physiology in the field of sports.Objectives:To analyze the scientific evidence on the influence of menstruation on the performance of female footballers, as well as to analyze the methodological quality of the studies included in this review.Materials and methods:The possible hormonal effects of the menstrual cycle phases on the performance of female footballers were analyzed. The databases used to conduct the searches were Pubmed, Scopus, Virtual Health Library, Web of Science, EBSCO and the Cochrane Library. All included studies met the inclusion criteria. The Cochrane risk of bias tool was used. This systematic review protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO: CRD42023390652).Results:A total of nine clinical trials were included in this review. A low quality of evidence was observed in the studies. Not all the results support the idea that the menstrual cycle phases can alter the performance of female footballers.Conclusion:This systematic review shows that there is a great deal of controversy about the influence of the menstrual cycle phases on the performance of female footballers. Studies are focused on solely biological factors and gender is normally no part of those studies. Further research with larger samples, and taking not only biological but also sociological factors, are necessary to determine the effects of menstruation on the performance of female footballers.

Frozen shoulder (FS), also known as adhesive capsulitis of the shoulder (FS), is a fibrotic inflammatory process of unknown etiology whose main symptoms are pain, stiffness and the loss of joint mobility. These symptoms may be associated with pathologies such as diabetes, Dupuytren’s syndrome and the prevalence of today’s sedentary lifestyle. This literature review provides an overview of the epidemiology and pathogenesis of this pathology, as well as the mechanisms of lowgrade chronic inflammation and infection, insulin resistance, and omics-science associated with it. We also propose a new hypothesis related to the possibility that the GABAergic system could play a decisive role in the development of frozen shoulder and that therefore diabetes type 1, endocrinological autoimmune disorders and frozen shoulder are connected by the same pathophysiological mechanisms. If that is true, the combined presence of psycho-emotional stress factors and pathogenic immune challenges could be the main causes of frozen shoulder syndrome. Finally, we propose a series of possible intervention strategies based on a multifactorial etiological and mechanistic concept.

With increasing numbers of chemicals used in modern society, assessing human and environmental exposure to them is becoming increasingly difficult. Recent advances in wastewater-based epidemiology enable valuable insights into public exposure to data-poor compounds. However, measuring all >26,000 chemicals registered under REACH is not just technically unfeasible but would also be incredibly expensive. In this paper, we argue that estimating emissions of chemicals based on usage data could offer a more comprehensive, systematic and efficient approach than repeated monitoring. Emissions of 29 active pharmaceutical ingredients (APIs) to wastewater were estimated for a medium-sized city in the Netherlands. Usage data was collected both on national and local scale and included prescription data, usage in health-care institutions and over-the-counter sales. Different routes of administration were considered as well as the excretion and subsequent in-sewer back-transformation of conjugates into respective parent compounds. Results suggest model-based emission estimation on a city-level is feasible and in good agreement with wastewater measurements obtained via passive sampling. Results highlight the need to include excretion fractions in the conceptual framework of emission estimation but suggest that the choice of an appropriate excretion fraction has a substantial impact on the resulting model performance.

Recensione a: Roncaglia A. (2023), Il potere. Una prospettiva riformista, Roma-Bari: Laterza, pp. 304, ISBN: 9788858151488.

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) has been used to treat refractory obsessive-compulsive disorder (OCD) and depression, but outcomes are variable, with some patients not responding to this form of invasive neuromodulation. A lack of benefit in some patients may be due to suboptimal positioning of DBS leads. Recently, studies have suggested that specific white matter tracts within the ALIC are associated with improved outcomes. Here, we present the case of a patient who initially had a modest improvement in OCD and depressive symptoms after receiving DBS within the ALIC. Subsequently, he underwent unilateral DBS lead repositioning informed by tractography targeting the ventrolateral and medial prefrontal cortex’s connection with the mediodorsal thalamus. In this patient, we also conducted post-implant and post-repositioning diffusion imaging and found that we could successfully perform tractography even with DBS leads in place. Following lead repositioning into tracts predictive of benefit, the patient reached responder criteria for his OCD, and his depression was remitted. This case illustrates that tractography can potentially be used in the evaluation and planning of lead repositioning to achieve therapeutic outcomes.

ObjectiveIn patients with complex coronary artery disease (CAD) undergoing cardiac surgery, myocardial protection might be impaired due to microvascular obstruction, resulting in myocardial injury and subsequent biomarker release. Therefore, this study investigated the correlation between the complexity of CAD, reflected by the SYNTAX Score, and the release of cardiac biomarkers after CABG.MethodsIn a consecutive series of 919 patients undergoing isolated CABG SYNTAX scores I and II were calculated to assess the complexity of CAD. Levels of high sensitivity cardiac troponin T (hs-cTnT) and creatine kinase-myocardial band (CK-MB) were routinely measured once before and serially after surgery. Patients were divided into tertiles according to their SYNTAX Scores I and II. Spearman correlations and regression models were performed to measure the degree of association between the release of hs-cTnT and CK-MB and the SYNTAX Scores.ResultsPatients with a higher SYNTAX Score I had more comorbidities reflected in a higher EuroSCORE II. Preoperatively, higher levels of cardiac biomarkers were found in patients with higher SYNTAX Score II. No correlation was observed between hs-cTnT, CK-MB and SYNTAX Score I or II. Regression models did not show any association between cardiac biomarkers and the complexity of CAD.ConclusionThe complexity of CAD is not associated with the release of cardiac biomarkers after CABG. Factors influencing postoperative biomarker release need to be elucidated in future trials to include postoperative biomarker release into risk stratification models predicting outcome after cardiac surgery.

Cross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past studies have reported a range of, sometimes conflicting, results. Some studies suggest that white matter properties act as individual-level traits predictive of reading skill, whereas others suggest that reading skill and white matter develop as a function of an individual’s educational experience. In the present study, we tested two hypotheses: a) that diffusion properties of the white matter reflect stable brain characteristics that relate to stable individual differences in reading ability or b) that white matter is a dynamic system, linked with learning over time. To answer these questions, we examined the relationship between white matter and reading in a five-year longitudinal dataset and a series of large-scale, single-observation, cross-sectional datasets (N = 14,249 total participants). We find that gains in reading skill correspond to longitudinal changes in the white matter. However, in the cross-sectional datasets, we find no evidence for the hypothesis that individual differences in white matter predict reading skill. These findings highlight the link between dynamic processes in the white matter and learning.

We introduce a new capability of the Neil Gehrels Swift Observatory, dubbed “continuous commanding,” that achieves 10 s latency response time on orbit to unscheduled target-of-opportunity requests received on the ground. We show that this will allow Swift to respond to premerger (early-warning) gravitational-wave (GW) detections, rapidly slewing the Burst Alert Telescope (BAT) across the sky to place the GW origin in the BAT field of view at or before merger time. This will dramatically increase the GW/gamma-ray burst (GRB) codetection rate and enable prompt arcminute localization of a neutron star merger. We simulate the full Swift response to a GW early-warning alert, including input sky maps produced at different early-warning times, a complete model of the Swift attitude control system, and a full accounting of the latency between the GW detectors and the spacecraft. 60 s of early warning can double the rate of a prompt GRB detection with arcminute localization, and 140 s guarantees observation anywhere on the unocculted sky, even with localization areas ≫1000 deg ^2 . While 140 s is beyond current GW detector sensitivities, 30–70 s is achievable today. We show that the detection yield is now limited by the latency of LIGO/Virgo cyberinfrastructure and motivate a focus on its reduction. Continuous commanding has been integrated as a general capability of Swift, significantly increasing its versatility in response to the growing demands of time-domain astrophysics. We demonstrate this potential on an externally triggered fast radio burst (FRB), slewing 81° across the sky, and collecting X-ray and UV photons from the source position

This study explores the visual phenomenon of random dot structure-from-motion (SFM), where the brain perceives 3D shapes from the coordinated 2D motion of dots. Observing SFM may lead to ambiguous depth relations that reverse back and forth during prolonged viewing. I demonstrate that different processes are involved in triggering perceived reversals for identical SFM shapes involved in spinning and wobbling motion. Durations of stable percepts were measured while human participants viewed the two SFM stimuli, and also a static Necker figure, and a wobbling Necker figure for two sets of 2.5 minutes each. The results showed that wobbling SFM resulted in much longer stable durations compared to the other stimuli. The durations for the wobbling SFM stimuli was not correlated with the spinning SFM, or the two Necker stimuli. Yet, such correlations were obtained between the other stimuli. It is known that reversals obtained while viewing spinning SFM stimuli involves bottom-up driven adaptation and recovery cycles between neural populations. This result suggests that wobbling SFM efficiently deactivates this process and targets other contributions to the reversals, such as top-down processes. In addition, biases observed in the first set disappeared in the second set implying influences of learning between the sets. Imagery vividness, which measures intrinsic top-down processes, was also scored but no correlation between scores in visual imagery and reversal rates were obtained. This research provides insight into the complex interplay between bottom-up driven adaptation-recovery cycles, and top-down processes in ambiguous perception.

Moore’s law states that the performance of computers doubles about every two years. This has dramatic consequences for any modern high development and for satellites. The long development cycles cause these expensive assets to be obsolete before the start of their operations. The advancement also presents challenges to their design, particularly from a thermal perspective, as more heat is dissipated and circuits are more fragile. These challenges mandate that faster spacecraft development methods are found and thermal management technologies are developed. We elaborate on existing development methodologies and present our own lean method. We explore the development of a thermal anomaly-detection payload, extending from conception to in-orbit commissioning, to stimulate discussions on space hardware development approaches. The payload consists of four miniaturized infrared cameras, heating sources in view of the cameras simulating an anomaly, an on-board processor, and peripherals for electrical and communication interfaces. The paper outlines our methodology and its application, showcasing the success of our efforts with the first-light activation of our cameras in orbit. We show our lean method, featuring reference technical and management models, from which we derive further development tools; such details are normally not available in the scientific-engineering literature. Additionally, we address the shortcomings identified during our development, such as the failure of an on-board component and propose improvements for future developments.

Background and Objectives: Current evidence confirms that the magnitude of the inter-rectus distance (IRD) is associated with the severity of abdominal pain. Furthermore, evidence exists in the literature about the impact abdominal muscles have on low back pain, lumbopelvic pain, breathing and lumbar abdominal strength; however, no studies analysing the level of association between abdominal diastasis and lumbar pain pressure threshold (PPT) exist. The aim of this study was to analyse the level of association between the rectus abdominis distance and pain pressure threshold in the lumbar spinous processes in women who have given birth between the ages of 30 and 45 years. Secondly, it was to study the level of association between the time elapsed since the last delivery and low back pain in women who have given birth between 30 and 45 years of age. Material and Methods: This was a pilot observational study in which 21 females participated. The abdominal diastasis was measured by ultrasound, the pain pressure threshold was assessed by an algometer and the pain perception by the Mc Gill questionnaire. Results: There was no significant relationship between increased abdominal distance and increased lumbopelvic pain in women who gave birth between the ages of 30 and 45 years. However, there was a correlation between the time that had elapsed since the last delivery and low back pain. Conclusions: there was a correlation between the time that had elapsed since the last delivery and low back pain. Further studies analysing factors that may perpetuate the chronicity of symptoms, such as lifestyle and intrinsic factors, are needed.

In this study, we assessed a highly structured, yearlong, case-based course designed for undergraduate pre-health students. We incorporated both content learning assessments and developed a novel method called Multiple Mini Exams for assessing course impact on the development of skills that professional schools often seek in pre-health students, focusing on students' abilities to collaborate with others, display bedside manners, synthesize patient case details, appropriately use scientific and medical language, and effectively attain patients' medical histories. This novel method utilized a rubric based on desired medical student skills to score videotaped behaviors and interactions of students role playing as doctors in a hypothetical patient case study scenario. Overall, our findings demonstrate that a highly structured course, incorporating weekly student performance and presentation of patient cases encompassing history taking, diagnosis, and treatment, can result in content learning, as well as improve desired skills specific for success in medical fields.