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Graph-based fraud detection has widespread application in modern industry scenarios, such as spam review and malicious account detection. While considerable efforts have been devoted to designing adequate fraud detectors, the interpretability of their results has often been overlooked. Previous works have attempted to generate explanations for specific instances using post-hoc explaining methods such as a GNNExplainer. However, post-hoc explanations can not facilitate the model predictions and the computational cost of these methods cannot meet practical requirements, thus limiting their application in real-world scenarios. To address these issues, we propose SEFraud, a novel graph-based self-explainable fraud detection framework that simultaneously tackles fraud detection and result in interpretability. Concretely, SEFraud first leverages customized heterogeneous graph transformer networks with learnable feature masks and edge masks to learn expressive representations from the informative heterogeneously typed transactions. A new triplet loss is further designed to enhance the performance of mask learning. Empirical results on various datasets demonstrate the effectiveness of SEFraud as it shows considerable advantages in both the fraud detection performance and interpretability of prediction results. Moreover, SEFraud has been deployed and offers explainable fraud detection service for the largest bank in China, Industrial and Commercial Bank of China Limited (ICBC). Results collected from the production environment of ICBC show that SEFraud can provide accurate detection results and comprehensive explanations that align with the expert business understanding, confirming its efficiency and applicability in large-scale online services., Comment: Accepted by KDD 2024