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113 results on '"Liebeskind, David S"'

1. Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6

Author

Kühn, Anna Luisa, Puri, Ajit S., Salim, Hamza Adel, Musmar, Basel, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Sweid, Ahmad, Naamani, Kareem El, Hasan, Zuha, Gopinathan, Anil, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Dyzmann, Christian, Kan, Peter T., Singh, Jasmeet, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Fahed, Robert, Tancredi, Illario, Faizy, Tobias D., Weyland, Charlotte, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2024
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4. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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5. Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Author

Wang, Maud, Henkes, Hans, Ghozy, Sherief, Siegler, James E., Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Sweid, Ahmad, Naamani, Kareem El, Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Weyland, Charlotte, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Patel, Aman B., Pereira, Vitor Mendes, Fahed, Robert, Lubicz, Boris, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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6. Effect of Bridging Thrombolysis on the Efficacy of Stent Retriever Thrombectomy Techniques: Insights from the SWIFT-DIRECT trial

Author

Pop, Raoul, Räty, Silja, Riva, Roberto, Marnat, Gaultier, Dobrocky, Tomas, Alexandre, Pierre Louis, Lefebvre, Margaux, Albucher, Jean Francois, Boulanger, Marion, Di Maria, Federico, Richard, Sébastien, Soize, Sébastien, Piechowiak, Eike Immo, Liman, Jan, Reich, Arno, Ribo, Marc, Meinel, Thomas, Mpotsaris, Anastasios, Liebeskind, David S., Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Published
2024
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9. ARISE I Consensus Review on the Management of Intracranial Aneurysms

Author

Tjoumakaris, Stavropoula I., Hanel, Ricardo, Mocco, J, Ali-Aziz Sultan, M., Froehler, Michael, Lieber, Barry B., Coon, Alexander, Tateshima, Satoshi, Altschul, David J., Narayanan, Sandra, El Naamani, Kareem, Taussky, Phil, Hoh, Brian L., Meyers, Philip, Gounis, Matthew J., Liebeskind, David S., Volovici, Victor, Toth, Gabor, Arthur, Adam, and Wakhloo, Ajay K.

Published
2024
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10. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial

Author

Wang, Yongjun, Wang, Yilong, Liu, Liping, Liebeskind, David S., Miao, Zhongrong, Ren, Zeguang, Pereira, Vitor Mendes, Ji, Xunming, Dong, Qiang, Xu, Anding, Liu, Xinfeng, Yang, Qingwu, Jing (Chair), Jing, Zhang, Zhe, Zhang, Yingkui, Wu, Wei, Sun, Dapeng, Qi, Zhongqi, Li, Shuo, Liu, Zhenqiang, Yu, Zequan, Zhang, Jingyu, Chen, Fangguang, Li, Kangyue, Zhang, Kai, Hu, Mingkai, Liu (Chair), Jianmin, Yao, Chen, Chen, Kangning, Fang (Chair), Kun, Song, Bo, Dong, Yi, Huo, Xiaochuan, Ma, Gaoting, Yuan, Guangxiong, Han, Hongxing, Chen, Wenhuo, Wei, Ming, Zhang, Jiangang, Zhou, Zhiming, Yao, Xiaoxi, Wang, Guoqing, Song, Weigen, Cai, Xueli, Nan, Guangxian, Li, Di, Wang, Yizhou, Ling, Wentong, Cai, Chuwei, Wen, Changming, Wang, En, Zhang, Liyong, Jiang, Changchun, Liu, Yajie, Liao, Geng, Chen, Xiaohui, Li, Tianxiao, Liu, Shudong, Li, Jinglun, Sun, Yaxuan, Xu, Na, Gao, Zong’en, Ju, Dongsheng, Song, Cunfeng, Xuan, Jinggang, Zhou, Feng, Shi, Qing, Luo, Jun, Liu, Yan, Guo, Zaiyu, Li, Tong, Zheng, Hongbo, Dai, Linzhi, Zhao, Junfeng, Gui, Liqiang, Geng, Xiaokun, Tang, Yufeng, Yin, Congguo, Yang, Hua, An, Ruiyang, Sun, Yuying, Wu, Yanan, Yu, Chunlai, Zheng, Shuangcheng, Pan, Yuesong, Jin, Aoming, Xiang, Xianglong, Wang, Mengxing, Yan, Hongyi, He, Yuanling, Li, Chunyang, Kong, Weixia, Chen, Yuhuan, Guo, Chenhao, Ji, Fengjie, Ji, Pengshan, Liu, Lei, Lu, Xinghua, Luo, Guangkuo, Wang, Nanjing, Zhang, Yu, Liu, Bo, Yang, Jian, Deng, Jingjing, Wang, Juan, Wang, Wanru, Yu, Hang, Cui, Le, Liu, Wenwen, Wang, Ziyong, Zhao, Xia, Zhou, Zhou, Yi-Chou Wang, Alvin, Zheng, Lina, Nie, Ximing, Liu, Xin, Duan, Wanying, Liu, Jingyi, Wei, Yufei, Wen, Miao, Yang, Zhonghua, Leung, Thomas W., Nguyen, Thanh N., and Leng, Xinyi

Published
2024
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11. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study

Author

Yaghi, Shadi, Shu, Liqi, Mandel, Daniel, Leon Guerrero, Christopher R., Henninger, Nils, Muppa, Jayachandra, Affan, Muhammad, Ul Haq Lodhi, Omair, Heldner, Mirjam R., Antonenko, Kateryna, Seiffge, David, Arnold, Marcel, Salehi Omran, Setareh, Crandall, Ross, Lester, Evan, Lopez Mena, Diego, Arauz, Antonio, Nehme, Ahmad, Boulanger, Marion, Touze, Emmanuel, Sousa, Joao Andre, Sargento-Freitas, Joao, Barata, Vasco, Castro-Chaves, Paulo, Brito, Maria Teresa, Khan, Muhib, Mallick, Dania, Rothstein, Aaron, Khazaal, Ossama, Kaufmann, Josefin E., Engelter, Stefan T., Traenka, Christopher, Aguiar de Sousa, Diana, Soares, Mafalda, Rosa, Sara, Zhou, Lily W., Gandhi, Preet, Field, Thalia S., Mancini, Steven, Metanis, Issa, Leker, Ronen R., Pan, Kelly, Dantu, Vishnu, Baumgartner, Karl, Burton, Tina, Von Rennenberg, Regina, Nolte, Christian H., Choi, Richard, MacDonald, Jason, Bavarsad Shahripour, Reza, Guo, Xiaofan, Ghannam, Malik, Almajali, Mohammad, Samaniego, Edgar A., Sanchez, Sebastian, Rioux, Bastien, Zine-Eddine, Faycal, Poppe, Alexandre, Fonseca, Ana Catarina, Baptista, Maria Fortuna, Cruz, Diana, Romoli, Michele, De Marco, Giovanna, Longoni, Marco, Keser, Zafer, Griffin, Kim, Kuohn, Lindsey, Frontera, Jennifer, Amar, Jordan, Giles, James, Zedde, Marialuisa, Pascarella, Rosario, Grisendi, Ilaria, Nzwalo, Hipolito, Liebeskind, David S., Molaie, Amir, Cavalier, Annie, Kam, Wayneho, Mac Grory, Brian, Al Kasab, Sami, Anadani, Mohammad, Kicielinski, Kimberly, Eltatawy, Ali, Chervak, Lina, Chulluncuy-Rivas, Roberto, Aziz, Yasmin, Bakradze, Ekaterina, Tran, Thanh Lam, Rodrigo-Gisbert, Marc, Requena, Manuel, Saleh Velez, Faddi, Ortiz Gracia, Jorge, Mudassani, Varsha, de Havenon, Adam, Vishnu, Venugopalan Y., Yaddanapudi, Sridhara, Adams, Latasha, Browngoehl, Abigail, Ranasinghe, Tamra, Dunston, Randy, Lynch, Zachary, Penckofer, Mary, Siegler, James, Mayer, Silvia, Willey, Joshua, Zubair, Adeel, Cheng, Yee Kuang, Sharma, Richa, Marto, João Pedro, Mendes Ferreira, Vítor, Klein, Piers, Nguyen, Thanh N., Asad, Syed Daniyal, Sarwat, Zoha, Balabhadra, Anvesh, Patel, Shivam, Secchi, Thais, Martins, Sheila, Mantovani, Gabriel, Kim, Young Dae, Krishnaiah, Balaji, Elangovan, Cheran, Lingam, Sivani, Quereshi, Abid, Fridman, Sebastian, Alvarado, Alonso, Khasiyev, Farid, Linares, Guillermo, Mannino, Marina, Terruso, Valeria, Vassilopoulou, Sofia, Tentolouris, Vasilis, Martinez-Marino, Manuel, Carrasco Wall, Victor, Indraswari, Fransisca, El Jamal, Sleiman, Liu, Shilin, Alvi, Muhammad, Ali, Farman, Sarvath, Mohammed, Morsi, Rami Z., Kass-Hout, Tareq, Shi, Feina, Zhang, Jinhua, Sokhi, Dilraj, Said, Jamil, Simpkins, Alexis N., Gomez, Roberto, Sen, Shayak, Ghani, Mohammad, Elnazeir, Marwa, Xiao, Han, Kala, Narendra, Khan, Farhan, Stretz, Christoph, Mohammadzadeh, Nahid, Goldstein, Eric, and Furie, Karen

Published
2024
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14. Developing a Coordinated Registry Network for devices used for acute ischemic stroke intervention: basilar artery occlusion quality assessment pilot

Author

Mao, Jialin, primary, Ansari, Sameer A, additional, Siddiqui, Adnan H, additional, Sedrakyan, Art, additional, Marinac-Dabic, Danica, additional, Sheldon, Murray, additional, Claffey, Mairsíl, additional, Hall, Alicia M, additional, Sancheti, Harsh, additional, Kim, Thomas, additional, Nguyen, Nam, additional, and Liebeskind, David S, additional

Published
2024
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15. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial

Author

Zheng, Lina, primary, Nie, Ximing, additional, Wang, Mengxing, additional, Liu, Xin, additional, Duan, Wanying, additional, Zhang, Zhe, additional, Liu, Jingyi, additional, Wei, Yufei, additional, Wen, Miao, additional, Yang, Zhonghua, additional, Leung, Thomas W., additional, Ma, Gaoting, additional, Huo, Xiaochuan, additional, Pan, Yuesong, additional, Nguyen, Thanh N., additional, Leng, Xinyi, additional, Miao, Zhongrong, additional, Liu, Liping, additional, Wang, Yongjun, additional, Wang, Yilong, additional, Liebeskind, David S., additional, Ren, Zeguang, additional, Pereira, Vitor Mendes, additional, Ji, Xunming, additional, Dong, Qiang, additional, Xu, Anding, additional, Liu, Xinfeng, additional, Yang, Qingwu, additional, Jing (Chair), Jing, additional, Zhang, Yingkui, additional, Wu, Wei, additional, Sun, Dapeng, additional, Qi, Zhongqi, additional, Li, Shuo, additional, Liu, Zhenqiang, additional, Yu, Zequan, additional, Zhang, Jingyu, additional, Chen, Fangguang, additional, Li, Kangyue, additional, Zhang, Kai, additional, Hu, Mingkai, additional, Liu (Chair), Jianmin, additional, Yao, Chen, additional, Chen, Kangning, additional, Fang (Chair), Kun, additional, Song, Bo, additional, Dong, Yi, additional, Yuan, Guangxiong, additional, Han, Hongxing, additional, Chen, Wenhuo, additional, Wei, Ming, additional, Zhang, Jiangang, additional, Zhou, Zhiming, additional, Yao, Xiaoxi, additional, Wang, Guoqing, additional, Song, Weigen, additional, Cai, Xueli, additional, Nan, Guangxian, additional, Li, Di, additional, Wang, Yizhou, additional, Ling, Wentong, additional, Cai, Chuwei, additional, Wen, Changming, additional, Wang, En, additional, Zhang, Liyong, additional, Jiang, Changchun, additional, Liu, Yajie, additional, Liao, Geng, additional, Chen, Xiaohui, additional, Li, Tianxiao, additional, Liu, Shudong, additional, Li, Jinglun, additional, Sun, Yaxuan, additional, Xu, Na, additional, Gao, Zong’en, additional, Ju, Dongsheng, additional, Song, Cunfeng, additional, Xuan, Jinggang, additional, Zhou, Feng, additional, Shi, Qing, additional, Luo, Jun, additional, Liu, Yan, additional, Guo, Zaiyu, additional, Li, Tong, additional, Zheng, Hongbo, additional, Dai, Linzhi, additional, Zhao, Junfeng, additional, Gui, Liqiang, additional, Geng, Xiaokun, additional, Tang, Yufeng, additional, Yin, Congguo, additional, Yang, Hua, additional, An, Ruiyang, additional, Sun, Yuying, additional, Wu, Yanan, additional, Yu, Chunlai, additional, Zheng, Shuangcheng, additional, Jin, Aoming, additional, Xiang, Xianglong, additional, Yan, Hongyi, additional, He, Yuanling, additional, Li, Chunyang, additional, Kong, Weixia, additional, Chen, Yuhuan, additional, Guo, Chenhao, additional, Ji, Fengjie, additional, Ji, Pengshan, additional, Liu, Lei, additional, Lu, Xinghua, additional, Luo, Guangkuo, additional, Wang, Nanjing, additional, Zhang, Yu, additional, Liu, Bo, additional, Yang, Jian, additional, Deng, Jingjing, additional, Wang, Juan, additional, Wang, Wanru, additional, Yu, Hang, additional, Cui, Le, additional, Liu, Wenwen, additional, Wang, Ziyong, additional, Zhao, Xia, additional, Zhou, Zhou, additional, and Yi-Chou Wang, Alvin, additional

Published
2024
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16. Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke

Author

Salim, Hamza, primary, Musmar, Basel, additional, Adeeb, Nimer, additional, Yedavalli, Vivek, additional, Lakhani, Dhairya, additional, Grewal, Sahibjot Singh, additional, El Naamani, Kareem, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kühn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Regenhardt, Robert W, additional, Heit, Jeremy J, additional, Cancelliere, Nicole M, additional, Bernstock, Joshua D, additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil, additional, Puri, Ajit S, additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Marotta, Thomas R, additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal, additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E, additional, Nguyen, Thanh N, additional, Varela, Ricardo, additional, Baker, Amanda, additional, Essibayi, Muhammed Amir, additional, Altschul, David, additional, Gonzalez, Nestor R, additional, Möhlenbruch, Markus A, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Mohammad Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S, additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M, additional, Tancredi, Illario, additional, Faizy, Tobias D, additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B, additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, Dmytriw, Adam A, additional, Amllay, Abdelaziz, additional, Vagal, Achala, additional, ter Schiphorst, Adrien, additional, Thomas, Ajith J., additional, Gopinathan, Anil, additional, Dusart, Anne, additional, Capirossi, Carolina, additional, Mounayer, Charbel, additional, Weyland, Charlotte, additional, Hsieh, Cheng-Yang, additional, Griessenauer, Christoph J., additional, Stapleton, Christopher J., additional, Bellante, Flavio, additional, Marnat, Gaultier, additional, Forestier, Géraud, additional, Cuellar-Saenz, Hugo H., additional, Valente, Iacopo, additional, Sibon, Igor, additional, Rabinov, James D., additional, Berge, Jérôme, additional, Jesser, Jessica, additional, Carlos Martinez-Gutierrez, Juan, additional, Premat, Kevin, additional, Yeo, Leonard LL., additional, Chervak, Lina, additional, Meyer, Lukas, additional, Elhorany, Mahmoud, additional, and Quintero-Consuegra, Miguel, additional

Published
2024
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17. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

Author

Costalat, Vincent, primary, Jovin, Tudor G., additional, Albucher, J.F., additional, Cognard, Christophe, additional, Henon, Hilde, additional, Nouri, Nasreddine, additional, Gory, Benjamin, additional, Richard, Sebastien, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Di Maria, Federico, additional, Annan, Mariam, additional, Boulouis, Grégoire, additional, Cardona, Pere, additional, Obadia, Michael, additional, Piotin, Michel, additional, Bourcier, Romain, additional, Guillon, Benoit, additional, Godard, Sophie, additional, Pasco-Papon, Anne, additional, Eker, Omer F., additional, Cho, Tae-Hee, additional, Turc, Guillaume, additional, Naggara, Olivier, additional, Velasco, Stéphane, additional, Lamy, Matthias, additional, Clarençon, Frédéric, additional, Alamowitch, Sonia, additional, Renu, Arturo, additional, Suissa, Laurent, additional, Brunel, Hervé, additional, Gentric, Jean-Christophe, additional, Timsit, Serge, additional, Lamy, Chantal, additional, Chivot, Cyril, additional, Macian-Montoro, Francisco, additional, Mounayer, Charbel, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrysanthi, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Ferrier, Anna, additional, Chabert, Emmanuel, additional, Ricolfi, Frédéric, additional, Béjot, Yannick, additional, Lopez-Cancio, Elena, additional, Vega, Pedro, additional, Spelle, Laurent, additional, Denier, Christian, additional, Millán, Mònica, additional, Arenillas, Juan F., additional, Mazighi, Mikael, additional, Houdart, Emmanuel, additional, del Mar Freijo, Maria, additional, Duhamel, Alain, additional, Sanossian, Nerses, additional, Liebeskind, David S., additional, Labreuche, Julien, additional, Lapergue, Bertrand, additional, and Arquizan, Caroline, additional

Published
2024
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18. Cross‐Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy

Author

Kaesmacher, Johannes, primary, Treurniet, Kilian M., additional, Kappelhof, Manon, additional, Dobrocky, Tomas, additional, Ospel, Johanna, additional, Mujanovic, Adnan, additional, Fiehler, Jens, additional, Yan, Bernard, additional, Goyal, Mayank, additional, Yoo, Albert J., additional, Campbell, Bruce, additional, Zaidat, Osama O., additional, Saver, Jeffrey L., additional, Sanossian, Nerses, additional, Raychev, Radoslav, additional, Roos, Yvo B. W. E. M., additional, Fischer, Urs, additional, Majoie, Charles B. L. M., additional, Gralla, Jan, additional, and Liebeskind, David S., additional

Published
2024
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20. HEMERA‐1 CarboxyHEMoglobin OxygEn Delivery for Evascularization in Acute Stroke: A Prospective, Randomized Phase 1 Clinical Trial

Author

Linfante, Italo, primary, Clark, Wayne, additional, Houssen, Diogo C., additional, Hanel, Ricardo, additional, Reshi, Rwoof, additional, Dabus, Guilherme, additional, Jubin, Ronald, additional, Roshan, Mona P., additional, Belnap, Star, additional, Nguyen, Thanh N., additional, Grotta, James, additional, Wicks, Robert, additional, Cipolla, Marilyn J., additional, Liebeskind, David S., additional, and Nogueira, Raul G., additional

Published
2024
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23. Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012)

Author

Misra, Shubham, primary, Dawson, Jesse, additional, Kwan, Patrick, additional, Kasner, Scott E., additional, Grotta, James C., additional, Larsson, David, additional, Tanaka, Tomotaka, additional, Zaveri, Hitten, additional, Wang, Selena, additional, Khan, Erum I., additional, Funaro, Melissa, additional, Perla, Sravan, additional, Dev, Priya, additional, Hussain, Taimoor, additional, Liebeskind, David S., additional, Yasuda, Clarissa, additional, Elshahat, Amr, additional, Hitawala, Gazala, additional, Wang, Ethan, additional, Kitagawa, Rachel, additional, Pathak, Abhishek, additional, Zhao, Yize, additional, Scalzo, Fabien, additional, Ihara, Masafumi, additional, Zelano, Johan, additional, Sunnerhagen, Katharina, additional, Walters, Matthew, additional, Jette, Nathalie, additional, Quinn, Terry, additional, and Mishra, Nishant, additional

Published
2024
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25. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Author

Albers, Gregory W., primary, Jumaa, Mouhammad, additional, Purdon, Barbara, additional, Zaidi, Syed F., additional, Streib, Christopher, additional, Shuaib, Ashfaq, additional, Sangha, Navdeep, additional, Kim, Minjee, additional, Froehler, Michael T., additional, Schwartz, Neil E., additional, Clark, Wayne M., additional, Kircher, Charles E., additional, Yang, Ming, additional, Massaro, Lori, additional, Lu, Xiao-Yu, additional, Rippon, Gregory A., additional, Broderick, Joseph P., additional, Butcher, Ken, additional, Lansberg, Maarten G., additional, Liebeskind, David S., additional, Nouh, Amre, additional, Schwamm, Lee H., additional, and Campbell, Bruce C.V., additional

Published
2024
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28. Abstract TMP72: Impaired Perfusion Predicts Early Recurrence in Symptomatic Intracranial Atherosclerosis

Author

Yaghi, Shadi, primary, Shu, Liqi, additional, de Havenon, Adam H, additional, Khatri, Pooja, additional, Torabi, Radmehr, additional, Jayaraman, Mahesh, additional, Moldovan, Krisztina, additional, Liebeskind, David S, additional, Prabhakaran, Shyam, additional, Khan, Farhan, additional, Goldstein, Eric, additional, and Furie, Karen L, additional

Published
2024
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29. Abstract WMP92: Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes After Acute Ischemic Stroke: An Analysis of the DAWN Trial

Author

Dohiem, Mohamed, primary, Jadhav, Ashutosh, additional, Aghaebrahim, Amin, additional, Frankel, Michael, additional, Jankowitz, Brian, additional, Budzik, Ronald, additional, Bonafe, Alain, additional, Bhuva, Parita, additional, Yavagal, Dileep R, additional, Hanel, Ricardo, additional, Hassan, Ameer E, additional, Ribo, Marc, additional, Cognard, Christophe, additional, Sila, Cathy, additional, Jenkins, Paul, additional, Morgan, Patricia M, additional, Smith, Wade, additional, Saver, Jeffrey, additional, Liebeskind, David S, additional, Jovin, Tudor, additional, Haussen, Diogo C, additional, and Nogueira, Raul G, additional

Published
2024
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32. Abstract 83: Early Notification Using a Novel Three-Tiered Code Stroke System Reduces Neurointerventional Team Activation Times

Author

Tariq, Muhammad Bilal, primary, Sharma, Latisha K, additional, Jahan, Reza, additional, Chatfield, Fiona, additional, Bahr-Hosseini, Mersedeh, additional, Colby, Geoffrey, additional, Duckwiler, Gary, additional, Hinman, Jason D, additional, Kaneko, Naoki, additional, Liebeskind, David S, additional, Mun, Katherine T, additional, Nour, May, additional, Szeder, Viktor, additional, Tateshima, Satoshi, additional, Alfonso, Rodel C, additional, and Saver, Jeffrey L, additional

Published
2024
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33. Abstract WP140: Perfusion Collateral Index Predicts Infarct Growth in Successfully Reperfused Patients With Acute Ischemic Stroke

Author

McArthur, Mark, primary, Kim, Daniel, additional, Tavakkol, Elham, additional, Qiao, Xin, additional, Salehi, Banafsheh, additional, Cai, Stephen, additional, Ledbetter, Luke, additional, Cankurtaran, Ceylan, additional, Bahr-Hosseini, Mersedeh, additional, Szeder, Viktor, additional, Colby, Geoffrey, additional, Jahan, Reza, additional, Duckwiler, Gary, additional, Saver, Jeffrey L, additional, Liebeskind, David S, additional, and Nael, Kambiz, additional

Published
2024
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34. Abstract WP212: Site vs. Core Lab Adjudicated eTICI Scores Compared During Off and Normal Hours - Insights From the ASSIST Registry

Author

Gupta, Rishi, primary, Miralbes, Salvador, additional, Naravetla, Bharath R, additional, Spiotta, Alejandro M, additional, Loehr, Christian, additional, Martínez-Galdámez, Mario, additional, McTaggart, Ryan, additional, Defreyne, Luc, additional, VEGA, PEDRO, additional, Zaidat, Osama O, additional, Price, Lori Lyn, additional, Liebeskind, David S, additional, and Moehlenbruch, Markus, additional

Published
2024
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36. Abstract 91: Patients With Intracranial Hemorrhage Have Greater Post-Stroke Mood Disturbance Than Those With Ischemic Stroke

Author

Kim, Min Sun, primary, Hickman, Leonard, additional, Mun, Katherine T, additional, Sanossian, Nerses, additional, Starkman, Sidney, additional, Avila, Gilda, additional, Sharma, Latisha K, additional, Liebeskind, David S, additional, Conwit, Robin A, additional, Hamilton, Scott, additional, and Saver, Jeffrey L, additional

Published
2024
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37. Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment

Author

Nogueira, Raul G., primary, Lobsien, Donald, additional, Klisch, Joachim, additional, Pielenz, Daniel, additional, Lobsien, Elmar, additional, Sauvageau, Eric, additional, Aghaebrahim, Nima, additional, Möhlenbruch, Markus, additional, Vollherbst, Dominik, additional, Ulfert, Christian, additional, Bozorgchami, Hormozd, additional, Clark, Wayne, additional, Priest, Ryan, additional, Samaniego, Edgar A., additional, Ortega-Gutierrez, Santiago, additional, Ghannam, Malik, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Keigher, Kiffon, additional, Haussen, Diogo C., additional, Al-Bayati, Alhamza R., additional, Siddiqui, Adnan, additional, Levy, Elad, additional, Chen, Michael, additional, Munich, Stephan, additional, Schramm, Peter, additional, Boppel, Tobias, additional, Narayanan, Sandra, additional, Gross, Bradley A., additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer, additional, Fifi, Johanna, additional, Budzik, Ron F., additional, Tarpley, Jason, additional, Starke, Robert M., additional, Raz, Eytan, additional, Brogan, Gary, additional, Liebeskind, David S., additional, and Hanel, Ricardo A., additional

Published
2024
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39. Value of intravenous alteplase before thrombectomy among patients with tandem lesions and emergent carotid artery stenting: A subgroup analysis of the SWIFT DIRECT trial.

Author

Mujanovic, Adnan, Dobrocky, Tomas, Pfeilschifter, Waltraud, Remonda, Luca, Caroff, Jildaz, Behme, Daniel, Seiffge, David J., Cereda, Carlo W., Kägi, Georg, Leyon, Joe, Piechowiak, Eike I., Costalat, Vincent, Wagner, Judith, Chabert, Emmanuel, Meinel, Thomas R., Jansen, Olav, Alonso, Angelika, Loehr, Christian, Liebeskind, David S., and Gralla, Jan

Subjects
CAROTID artery, TREATMENT effect heterogeneity, INTERNAL carotid artery, THROMBECTOMY, SUBGROUP analysis (Experimental design), ENDARTERECTOMY
Abstract

Background and purpose: The value of intravenous thrombolysis (IVT) in eligible tandem lesion patients undergoing endovascular treatment (EVT) is unknown. We investigated treatment effect heterogeneity of EVT + IVT versus EVT‐only in tandem lesion patients. Additional analyses were performed for patients undergoing emergent internal carotid artery (ICA) stenting. Methods: SWIFT DIRECT randomized IVT‐eligible patients to either EVT + IVT or EVT‐only. Primary outcome was 90‐day functional independence (modified Rankin Scale score 0–2) after the index event. Secondary endpoints were reperfusion success, 24 h intracranial hemorrhage rate, and 90‐day all‐cause mortality. Interaction models were fitted for all predefined outcomes. Results: Among 408 included patients, 63 (15.4%) had a tandem lesion and 33 (52.4%) received IVT. In patients with tandem lesions, 20 had undergone emergent ICA stenting (EVT + IVT: 9/33, 27.3%; EVT: 11/30, 36.7%). Tandem lesion did not show treatment effect modification of IVT on rates of functional independence (tandem lesion EVT + IVT vs. EVT: 63.6% vs. 46.7%, non‐tandem lesion EVT + IVT vs. EVT: 65.6% vs. 58.2%; p for interaction = 0.77). IVT also did not increase the risk of intracranial hemorrhage among tandem lesion patients (tandem lesion EVT + IVT vs. EVT: 34.4% vs. 46.7%, non‐tandem lesion EVT + IVT vs. EVT: 33.5% vs. 26.3%; p for interaction = 0.15). No heterogeneity was noted for other endpoints (p for interaction > 0.05). Conclusions: No treatment effect heterogeneity of EVT + IVT versus EVT‐only was observed among tandem lesion patients. Administering IVT in patients with anticipated emergent ICA stenting seems safe, and the latter should not be a factor to consider when deciding to administer IVT before EVT. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden.

Author

Eun, Mi-Yeon, Song, Ha‑Na, Choi, Jong‑Un, Cho, Hwan‑Ho, Kim, Hyung Jun, Chung, Jong-Won, Song, Tae-Jin, Jung, Jin-Man, Bang, Oh‑Young, Kim, Gyeong‑Moon, Park, Hyunjin, Liebeskind, David S., and Seo, Woo-Keun

Subjects
TORTUOSITY, MAGNETIC resonance angiography, STROKE patients, ISCHEMIC stroke
Abstract

The effect of arterial tortuosity on intracranial atherosclerosis (ICAS) is not well understood. This study aimed to evaluate the effect of global intracranial arterial tortuosity on intracranial atherosclerotic burden in patients with ischemic stroke. We included patients with acute ischemic stroke who underwent magnetic resonance angiography (MRA) and classified them into three groups according to the ICAS burden. Global tortuosity index (GTI) was defined as the standardized mean curvature of the entire intracranial arteries, measured by in-house vessel analysis software. Of the 516 patients included, 274 patients had no ICAS, 140 patients had a low ICAS burden, and 102 patients had a high ICAS burden. GTI increased with higher ICAS burden. After adjustment for age, sex, vascular risk factors, and standardized mean arterial area, GTI was independently associated with ICAS burden (adjusted odds ratio [adjusted OR] 1.33; 95% confidence interval [CI] 1.09–1.62). The degree of association increased when the arterial tortuosity was analyzed limited to the basal arteries (adjusted OR 1.48; 95% CI 1.22–1.81). We demonstrated that GTI is associated with ICAS burden in patients with ischemic stroke, suggesting a role for global arterial tortuosity in ICAS. [ABSTRACT FROM AUTHOR]

Published
2024
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41. MRI vs CT for Baseline Imaging Evaluation in Acute Large Artery Ischemic Stroke

Author

Fladt, Joachim, primary, Kaesmacher, Johannes, additional, Meinel, Thomas R., additional, Bütikofer, Lukas, additional, Strbian, Daniel, additional, Eker, Omer F., additional, Albucher, Jean-Francois, additional, Desal, Hubert, additional, Marnat, Gaultier, additional, Papagiannaki, Chrysanthi, additional, Richard, Sebastien, additional, Requena, Manuel, additional, Lapergue, Bertrand, additional, Pagano, Paolo, additional, Ernst, Marielle, additional, Wiesmann, Martin, additional, Boulanger, Marion, additional, Liebeskind, David S., additional, Gralla, Jan, additional, and Fischer, Urs, additional

Published
2024
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42. Technique and impact on first pass effect primary results of the ASSIST global registry

Author

Gupta, Rishi, primary, Miralbés, Salvador, additional, Calleja Bonilla, Angel, additional, Naravetla, Bharath, additional, Majjhoo, Aniel Q, additional, Rayes, Mahmoud, additional, Spiotta, Alejandro M, additional, Loehr, Christian, additional, Cioltan, Andreea, additional, Vollherbst, Dominik F, additional, Martínez-Galdámez, Mario, additional, Galván-Fernandez, Jorge, additional, Khaldi, Ahmad, additional, McTaggart, Ryan A., additional, Jayaraman, Mahesh V, additional, Defreyne, Luc, additional, Dhondt, Elisabeth, additional, Vega, Pedro, additional, Murias, Eduardo, additional, Lin, Eugene, additional, Chaubal, Varun, additional, Price, Lori Lyn, additional, Liebeskind, David S, additional, and Möhlenbruch, Markus A, additional

Published
2024
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45. Endovascular Therapy vs. Best Medical Management in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study

Author

Salim, Hamza A., primary, Yedavalli, Vivek, additional, Musmar, Basel, additional, Adeeb, Nimer, additional, Naamani, Kareem El, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kuhn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Heit, Jeremy J., additional, Regenhardt, Robert, additional, Cancelliere, Nicole M., additional, Bernstock, Joshua D., additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil A., additional, Essibayi, Muhammed Amir, additional, Puri, Ajit S., additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Marotta, Thomas R., additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal M., additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E., additional, Nguyen, Thanh N., additional, Varela, Ricardo, additional, Baker, Amanda, additional, Altschul, David, additional, Gonzalez, Nestor R., additional, Mohlenbruch, Markus, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S., additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M., additional, Tancredi, Illario, additional, Faizy, Tobias D., additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B., additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, and Dmytriw, Adam A., additional

Published
2024
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46. Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study

Author

Dmytriw, Adam A, Musmar, Basel, Salim, Hamza, Ghozy, Sherief, Siegler, James E, Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N, Heit, Jeremy J, Regenhardt, Robert W, Cancelliere, Nicole M, Bernstock, Joshua D, Naamani, Kareem El, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S, Dyzmann, Christian, Kan, Peter T, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R, Stapleton, Christopher J, Rabinov, James D, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL, Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina, Vagal, Achala, Adeeb, Nimer, Cuellar-Saenz, Hugo H, Tjoumakaris, Stavropoula I, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R, Möhlenbruch, Markus A, Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J, Thomas, Ajith J, Hsieh, Cheng-Yang, Liebeskind, David S, Alexandru Radu, Răzvan, Alexandre, Andrea M, Tancredi, Illario, Faizy, Tobias D, Fahed, Robert, Weyland, Charlotte, Lubicz, Boris, Patel, Aman B, Pereira, Vitor Mendes, and Guenego, Adrien

Abstract

Background: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO.Methods: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed.Results: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p= 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p< 0.001; TICI 2b-3: 56.5% vs 88.3%, p< 0.001). Functional outcomes were also worse in the perforation group (mRS 0–1 at 3 months: 22.7% vs 36.6%, p= 0.031; mRS 0–2 at 3 months: 28.8% vs 53.9%, p< 0.001). Mortality was higher in the perforation group (30.3% vs 16.8%, p= 0.008).Conclusion: This study reveals that while the occurrence of vessel perforation in MT for AIS due to MeVO is relatively rare, it is associated with poor functional outcomes and higher mortality. The findings highlight the need for increased caution and specialized training in performing MT for MeVO. Further prospective research is required for risk mitigation strategies.

Published
2024
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47. The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation.

Author

Cipolla, Marilyn J., Hunt, Ryan D., Liebeskind, David S., and Tremble, Sarah M.

Subjects
STROKE, CEREBRAL circulation, HEMODYNAMICS, COLLATERAL security, RATS
Abstract

Introduction: Stroke interventions that increase collateral flow have the potential to salvage penumbral tissue and increase the number of patients eligible for reperfusion therapy. We compared the efficacy of two different collateral therapeutics during transient middle cerebral artery occlusion (tMCAO) in normotensive and hypertensive rats. Methods: The change in collateral and core perfusion was measured using dual laser Doppler in response to either a pressor agent (phenylephrine, 10mg/kg iv or vehicle) or a collateral vasodilator (TM5441, 5mg/kg iv or vehicle) given 30min into tMCAO in male Wistar and spontaneously hypertensive rats (SHRs). Results: Pressor therapy increased collateral flow in the Wistar rats but was ineffective in the SHRs. The increase in collateral flow in the Wistar rats was associated with impaired cerebral blood flow autoregulation (CBFAR) that was intact in the SHRs. TM5441 caused a decrease in collateral perfusion in the Wistar rats and a modest increase in the SHRs. The pressor therapy reduced early infarction in both groups but increased edema in the SHRs, whereas TM5441 did not have any beneficial effects in either group. Conclusions: Thus, the pressor therapy was superior to a collateral vasodilator in increasing collateral flow and improving outcomes in the Wistar rats, likely due to pial collaterals that were pressure passive; the lack of CBF response in the SHRs to pressor therapy was likely due to intact CBFAR that limited perfusion. While TM5441 modestly increased CBF in the SHRs but not in the Wistar rats, it did not have a beneficial effect on stroke outcomes. These results suggest that collateral therapies may need to be selected for certain comorbidities. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Evaluation of effectiveness and safety of the CorPath GRX robotic system in endovascular embolization procedures of cerebral aneurysms.

Author

Mendes Pereira, Vitor, Rice, Hal, De Villiers, Laetitia, Sourour, Nader, Clarencon, Frédéric, Spears, Julian, Tomasello, Alejandro, Hernandez, David, Cancelliere, Nicole M., Xiao Yu Eileen Liu, Nicholson, Patrick, Costalat, Vincent, Gascou, Gregory, Mordasini, Pasquale, Gralla, Jan, Martínez-Galdámez, Mario, Galvan Fernandez, Jorge, Killer-Oberpfalzer, Monika, Liebeskind, David S., and Turner, Raymond D.

Subjects
INTRACRANIAL aneurysm surgery, SURGICAL robots, INTRACRANIAL aneurysms, CEREBRAL angiography, PEARSON correlation (Statistics), PATIENT safety, STATISTICAL significance, RESEARCH funding, THERAPEUTIC embolization, ENDOVASCULAR surgery, TREATMENT effectiveness, SURGICAL stents, DESCRIPTIVE statistics, LONGITUDINAL method, RESEARCH, CONFIDENCE intervals, DATA analysis software
Abstract

Background Robotic-assisted neurointervention was recently introduced, with implications that it could be used to treat neurovascular diseases. Objective To evaluate the effectiveness and safety of the robotic-assisted platform CorPath GRX for treating cerebral aneurysms. Methods This prospective, international, multicenter study enrolled patients with brain aneurysms that required endovascular coiling and/or stent-assisted coiling. The primary effectiveness endpoint was defined as successful completion of the robotic-assisted endovascular procedure without any unplanned conversion to manual treatment with guidewire or microcatheter navigation, embolization coil(s) or intracranial stent(s) deployment, or an inability to navigate vessel anatomy. The primary safety endpoint included intraprocedural and periprocedural events. Results The study enrolled 117 patients (74.4% female) with mean age of 56.6 years from 10 international sites,. Headache was the most common presenting symptom in 40/117 (34.2%) subjects. Internal carotid artery was the most common location (34/122, 27.9%), and the mean aneurysm height and neck width were 5.7±2.6 mm and 3.5±1.4 mm, respectively. The overall procedure time was 117.3±47.3 min with 59.4±32.6 min robotic procedure time. Primary effectiveness was achieved in 110/117 (94%) subjects with seven subjects requiring conversion to manual for procedure completion. Only four primary safety events were recorded with two intraprocedural aneurysm ruptures and two strokes. A Raymond-Roy Classification Scale score of 1 was achieved in 71/110 (64.5%) subjects, and all subjects were discharged with a modified Rankin Scale score of ≤2. Conclusions This first-of-its-kind robotic-assisted neurovascular trial demonstrates the effectiveness and safety of the CorPath GRX System for endovascular embolization of cerebral aneurysm procedures. [ABSTRACT FROM AUTHOR]

Published
2024
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50. First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Fahed, Robert, Ghozy, Sherief, Siegler, James E, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N, Heit, Jeremy J, Sweid, Ahmad, El Naamani, Kareem, Regenhardt, Robert W, Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S, Dyzmann, Christian, Kan, Peter T, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Kyheng, Maéva, Marotta, Thomas R, Stapleton, Christopher J, Rabinov, James D, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL, Tan, Benjamin YQ, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Pedro Filipe, João, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R, Möhlenbruch, Markus A, Jesser, Jessica, Tancredi, Illario, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J, Thomas, Ajith J, Hsieh, Cheng-Yang, Liebeskind, David S, Alexandre, Andrea M, Faizy, Tobias D, Weyland, Charlotte, Patel, Aman B, Pereira, Vitor Mendes, Lubicz, Boris, Dmytriw, Adam A, and Guenego, Adrien

Abstract

Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce.Patients and Methods: We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0–2 at 3 months.Results: Eight hundred thirty-six patients with a final mTICI ⩾ 2b were included in this analysis. FPE was observed in 302 patients (36.1%). In multivariable analysis, hypertension (aOR 1.55, 95% CI 1.10–2.20) and lower baseline NIHSS score (aOR 0.95, 95% CI 0.93–0.97) were independently associated with an FPE. Good outcomes were more common in the FPE versus non-FPE group (72.8% vs 52.8%), and FPE was independently associated with favorable outcome (aOR 2.20, 95% CI 1.59–3.05). 90-day mortality and intracranial hemorrhage (ICH) were significantly lower in the FPE group, 0.43 (95% CI, 0.25–0.72) and 0.55 (95% CI, 0.39–0.77), respectively.Conclusion: Over 2/3 of patients with MeVOs and FPE in our cohort had a favorable outcome at 90 days. FPE is independently associated with favorable outcomes, it may reduce the risk of any intracranial hemorrhage, and 3-month mortality.

Published
2024
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