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Background: To systematically evaluate the relationship between the expression level of long noncoding RNA NEAT1 and the clinical characteristics and prognostic value of rectal cancer patients. Methods: PubMed, EMBASE, Cochrane library database and case-control studies on the correlation between abnormal expression of lncRNA NEAT1 and prognosis of rectal cancer patients published by the American clinical trials registry before May 1, 2023 were searched. The search time was from the establishment of the database to May 30, 2023. Results: A total of 7 case-control studies were included, including 1063 cancer patients. The results of meta-analysis showed that the high expression of lncRNA NEAT1 was significantly correlated with the degree of differentiation [or=0.45, 95%CI=0.32-0.63, P

This paper analyzes and studies the tactics in basketball games using the main branches of cluster analysis using multivariate statistical methods. A brief overview of multivariate statistical analysis is summarized by analyzing the application of multivariate statistical methods. The main method for classifying basketball tactics is cluster analysis, and nonlinear programming functions with constraints are constructed using mean square approximation theory. The classification results are reasonable when combined with the least square error sum. According to the results, man-to-man defensive tactics were most frequently used in basketball, with 72 instances accounting for 75.19% of all defensive strategies. The most frequent offensive tactic in the basketball game was dribbling with a fast break, and 15 times succeeded in scoring during 20 dribbling with a fast break in the first half, with a success rate of 75%.

Background: Osteosarcoma (OS) is a highly metastatic primary bone malignancy, and the treatment options remain inadequate. Hence, exploring innovative natural medications is required. Prunetin (PRU) is an isoflavone that has been a proven anticancer agent in numerous cancer cell lines. However, the activity of PRU against OS remains uncertain. Materials and Methods: Here, we studied the anticancer activity of PRU (20 and 25 µM) on human OS cells MG-63 and investigated its latent mechanism. The PRU activity of MG-63 cells cytotoxicity, intracellular ROS, metastasis, apoptosis, anti-apoptotic proteins, MAPK/STAT-3, and AKT signaling pathways was assessed by MTT assay, DCFH-DA, DAPI, PI, AO/EB, cell adhesion, and RT-PCR analysis. Findings unveiled that PRU could constrain MG-63 cell viability and adhesion through elevated intracellular ROS and elicited apoptosis. Results: Likewise, PRU (20 and 25 µM) avert the MG-63 cell proliferation, which stimulates apoptosis by the enhancement of Bax and caspases, while it diminishes Bcl-2 in a dose-dependent way. Furthermore, PRU could reduce Pin-1, and anti-apoptotic elements, as well as trigger apoptotic signaling pathways. Our data established that PRU alleviates MG-63 cell proliferation and metastasis via ROS-mediated apoptosis, which triggers MAPKs/STAT3 and AKT pathways, suggesting that PRU is a promising natural remedy for OS. In order to comprehend the therapeutic target for cancer, we assessed the effect of PRU on the expression of Pin1, which is thought to be over-expressed in many human malignancies. According to our findings, PRU specifically suppressed Pin1 expression to reduce the expression of Akt, STAT3, P38, JNK, P65, and IL-6. We evaluated the impact of PRU on the expression of Pin1, which is allegedly over-expressed in many human malignancies, to better understand the therapeutic target for cancer. Researchers state that PRU inhibited the expression of Akt, STAT3, P38, JNK, P65, and IL-6 in particular, by suppressing Pin1 expression. Conclusion: Together, these results suggest that PRU may be an effective treatment for bone cancer in people by preventing Pin1 expression. [ABSTRACT FROM AUTHOR]

Physical and climatic variables such as Tree Canopy coverage, Normalized Difference Vegetation Index (NDVI), Distance to Roads, Distance to the Coast, Impervious Surface, and Precipitation can affect land surface temperature (LST). This paper examines the relationships using linear regression models and explores LST trends in the Miami Statistical Area (MSA) between 2002 and 2021. This study evaluates the effect of dry and wet seasons as well as day and night data on LST. A multiscale investigation is used to examine LST trends at the MSA scale, the individual county level, and at the pixel level to provide a detailed local perspective. The multiscale results are needed to understand spatiotemporal LST distributions to plan mitigation measures such as planting trees or greenery to regulate temperature and reduce the impacts of surface urban heat islands. The results indicate that LST values are rising in the MSA with a positive trend throughout the 20-year study period. The rate of change (RoC) for the wet season is smaller than for the dry season. The pixel-level analysis suggests that the RoC is primarily in rural areas and less apparent in urban areas. New development in rural areas may trigger increased RoC. This RoC relates to LST in the MSA and is different from global or regional RoC using air temperature. Results also suggest that climatic explanatory variables have different impacts during the night than they do in the daytime. For instance, the Tree Canopy variable has a positive coefficient, while during the day, the Tree Canopy variable has a negative relationship with LST. The Distance to the Coast variable changes from day to night as well. The increased granularity achieved with the multiscale analysis provides critical information needed to improve the effectiveness of potential mitigation efforts. [ABSTRACT FROM AUTHOR]

Most toughening methods for epoxy resins are usually used at the expense of other properties. Some polyhedral oligomeric silsesquioxanes (POSSs) with both a rigid Si-O-Si structure and flexible organic chain segments could be expected to be effective toughening agents. In this study, three reactive polyhedral oligomeric silsesquioxanes with a thiol group (OMPPS), a carboxyl group (OCOPS), and an epoxy group (OGCPS) were synthesized and characterized. They were utilized as modifiers to toughen 3-(oxiran-2-ylmethoxy)- N , N -bis(oxiran-2-ylmethyl)aniline (AFG-90MH)/4,4'-methylenebis(2-ethylaniline) (MOEA) (epoxy resin) with different molar ratios to obtain hybrid resins named OMPPS-EP-i, OCOPS-EP-j, and OGCPS-EP-k. The effects of the amount of modifier added and the length of the organic chain on the cage structure on various properties of the hybrid resins were investigated. The results show that all three modifiers show good compatibility with the epoxy resin. The hybrid resins have a low viscosity at 45~85 °C and can be cured at a low temperature (110 °C). The cured hybrid resins display improved toughness. Typically, the critical stress intensity factor (K IC ) and impact strength of OGCPS-EP-0.6-C are 2.54 MPa∙m -1/2 and 19.33 kJ∙m -2 , respectively, which increased by 58.75% and 22.48% compared with the pristine epoxy resin, respectively. In addition, the glass transition temperature and flexural strength of the hybrid resins are basically unchanged.