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The advent of three-dimensional (3D) bioprinting offers a feasible approach to construct complex structures for soft tissue regeneration. Carboxymethyl cellulose (CMC) has been emerging as a very promising biomaterial for 3D bioprinting. However, due to the inability to maintain the post-printed stability, CMC needs to be physically blended and/or chemically crosslinked with other polymers. In this context, this study presents the combination of CMC with xanthan gum (XG) and hyaluronic acid (HA) to formulate a multicomponent bioink, leveraging the printability of CMC and XG, as well as the cellular support properties of HA. The ionic crosslinking of printed constructs with iron(III) via the metal-ion coordination between ferric cations and carboxylate groups of the three polymers was introduced to induce improved mechanical strength and long-term stability. Moreover, immortalized human epidermal keratinocytes (HaCaT) and human foreskin fibroblasts (HFF) encapsulated within iron-crosslinked printed hydrogels exhibited excellent cell viability (more than 95%) and preserved morphology. Overall, the presented study highlights that the combination of these three biopolymers and the ionic crosslinking with ferric ions is a valuable strategy to be considered for the development of new and advanced hydrogel-based bioinks for soft tissue engineering applications. [ABSTRACT FROM AUTHOR]

Poor interfacial contact between solid‐state electrolytes and electrodes limits high‐voltage performance of solid‐state lithium batteries. A new gel electrolyte is proposed via in‐situ polymerization, incorporating fluoroethylene carbonate (FEC) solvent and ionic liquid1‐butyl‐1‐methylpiperidinium bis(trifluoromethylsulfonyl)imide (PP14TFSI). This combination synergistically enhances Li ion transport, achieving a transfer number of 0.58 and improved electrochemical performance. FEC protects the Al current collectors from LiPF6 corrosion and promotes a protective interfacial layer formation. PP14TFSI improves interfacial contact and provides stable components. An interface layer of fluorine and nitrogen composites forms, preventing side reactions. LiCoO2||PPE||Li cell exhibits robust cycling stability at 4.45 V, retaining ~80 % capacity after 200 cycles at room temperature with 0.2 C and 1 C rates, showing increased coulombic efficiency. NCM811||PPE||Li cell also displays exceptional cycling. In‐situ polymerization and FEC‐ionic liquid coordination enable high‐voltage solid‐state lithium metal batteries for practical use. [ABSTRACT FROM AUTHOR]

The application of solar steam generation in seawater desalination is an effective way to solve the shortage of fresh water resources. At present, many kinds of photothermal conversion materials have been developed and used as evaporators in seawater desalination. However, some evaporators need additional thermal insulation or water supply devices to achieve efficient photothermal conversion. In addition, their complex, time consuming and no scalable preparation process, high cost of raw materials and poor salt resistance hinder the practical application of these evaporator. Owing to its distinctive nanoporous structure, diatomite as fossilized single-cells algae diatoms is a promising natural silica-based material for seawater desalination. They are taken from sea and that makes true sense to use them in the sea. Herein, we report the first example of synthesis robust three-dimensional (3D) natural-diatomite composite by assembling polyaniline nanoparticles covered diatomite into the polyvinyl alcohol pre-treated melamine foam frameworks and demonstrate its application as new evaporator for seawater desalination. The porous framework does not only improve the sunlight scattering efficiency, but also offer large network of channels for water transportation. The inherent mechanism behind salt desalination process involves the absorption of water molecules on the surface of the internal silica micro-nano pores, and evaporation under the heat induced by the polyaniline absorbed sunlight. Meanwhile, the metal ions are segregated by many available pores and channels to achieve the self-desalting effect. The developed evaporator possesses the superiority of multi-stage pore structure, strong hydrophilicity, low thermal conductivity, excellent light absorption, fast water transportation and salt-resistant crystallization as well as good durability. The evaporation rate without an additional device is found to be 1.689 kg m-2 h-1 under 1-Sun irradiation, and the energy conversion efficiency is as high as 95%. This work creates a platform and develops the prospect of employing green and sustainable natural-diatomite composite evaporator for practical applications of seawater desalination. [ABSTRACT FROM AUTHOR]

Curcumin (Cur) is an acidic polyphenol with some effects on α‐glucosidase (α‐Glu), but Cur has disadvantages such as being a weak target, lacking passing the blood–brain barrier and having low bioavailability. To enhance the curative effect of Cur, the hybrid composed of ZnO nanoparticles decorated on rGO was used to load Cur (ZnO@rGO‐Cur). The use of the multispectral method and enzyme inhibition kinetics analysis certify the inhibitory effect and interaction mechanism of ZnO@rGO‐Cur with α‐Glu. The static quenching of α‐Glu with both Cur and ZnO@rGO‐Cur is primarily driven by hydrogen bond and van der Waals interactions. The conformation‐changing ability by binding to the neighbouring phenolic hydroxyl group of Cur increased their ability to alter the secondary structure of α‐Glu, resulting in the inhibition of enzyme activity. The inhibition constant (Ki, Cur > Kis,ZnO@rGO‐Cur) showed that the inhibition effect of ZnO@rGO‐Cur on α‐Glu was larger than that of Cur. The CCK‐8 experiments proved that ZnO@rGO nanocomposites have good biocompatibility. These results suggest that the therapeutic potential of ZnO@rGO‐Cur composite is an emerging nanocarrier platform for drug delivery systems for the potential treatment of diabetes mellitus. [ABSTRACT FROM AUTHOR]

The extensive use of the antibiotic oxytetracycline (OTC) has led to considerable environmental contamination and other negative impacts, prompting an urgent need for a green, effective, and innovative OTC adsorption material. In this study, diatom-allophane bio-nanocomposites were synthesized using a simple and eco-friendly method, yielding a homogeneous coating of allophane nanoparticles on diatom surfaces. The resultant bio-nanocomposites were found to have hierarchically porous structures and abundant active sites derived from successful allophane loading and dispersion on diatom surfaces. The OTC adsorption capacity of this novel adsorbent is remarkable (219.112 mg·g -1 ), surpassing the capacities of raw allophane and diatoms by >5 and 10 times, respectively. Mechanistically, OTC adsorption by the bio-nanocomposites was found to be driven primarily by chemisorption through a process involving complexation between the amide and amino groups on OTC and the aluminum hydroxyl and carboxyl groups on the adsorbent surface. Electrostatic interactions and hydrogen bonding also contribute significantly to OTC capture. Furthermore, the diatom-allophane bio-nanocomposites exhibit excellent performance over a wide pH range (4-7), in the presence of various cations (Na + , K + , Ca 2+ , Mg 2+ ) and anions (Cl - , NO 3 - , SO 4 2- ), and in real water bodies. These findings demonstrate the potential of the diatom-allophane bio-nanocomposite as a green, efficient, and promising biological-mineral adsorbent for environmental remediation, leveraging the combined utilization of biological and mineral resources., (Copyright © 2024. Published by Elsevier B.V.)

Conventional diagnostic methods for lung cancer, based on breath analysis using gas chromatography and mass spectrometry, have limitations for fast screening due to their limited availability, operational complexity, and high cost. As potential replacement, among several low-cost and portable methods, chemoresistive sensors for the detection of volatile organic compounds (VOCs) that represent biomarkers of lung cancer were explored as promising solutions, which unfortunately still face challenges. To address the key problems of these sensors, such as low sensitivity, high response time, and poor selectivity, this study presents the design of new chemoresistive sensors based on hybridised porous zeolitic imidazolate (ZIF-8) based metal-organic frameworks (MOFs) and laser-scribed graphene (LSG) structures, inspired by the architecture of the human lung. The sensing performance of the fabricated ZIF-8@LSG hybrid sensors was characterised using four dominant VOC biomarkers, including acetone, ethanol, methanol, and formaldehyde, which are identified as metabolomic signatures in lung cancer patients' exhaled breath. The results using simulated breath samples showed that the sensors exhibited excellent performance for a set of these biomarkers, including fast response (2-3 seconds), a wide detection range (0.8 ppm to 50 ppm), a low detection limit (0.8 ppm), and high selectivity, all obtained at room temperature. Intelligent machine learning (ML) recognition using the multilayer perceptron (MLP)-based classification algorithm was further employed to enhance the capability of these sensors, achieving an exceptional accuracy (approximately 96.5%) for the four targeted VOCs over the tested range (0.8-10 ppm). The developed hybridised nanomaterials, combined with the ML methodology, showcase robust identification of lung cancer biomarkers in simulated breath samples containing multiple biomarkers and a promising solution for their further improvements toward practical applications.

Curcumin (Cur) is an acidic polyphenol with some effects on α-glucosidase (α-Glu), but Cur has disadvantages such as being a weak target, lacking passing the blood-brain barrier and having low bioavailability. To enhance the curative effect of Cur, the hybrid composed of ZnO nanoparticles decorated on rGO was used to load Cur (ZnO@rGO-Cur). The use of the multispectral method and enzyme inhibition kinetics analysis certify the inhibitory effect and interaction mechanism of ZnO@rGO-Cur with α-Glu. The static quenching of α-Glu with both Cur and ZnO@rGO-Cur is primarily driven by hydrogen bond and van der Waals interactions. The conformation-changing ability by binding to the neighbouring phenolic hydroxyl group of Cur increased their ability to alter the secondary structure of α-Glu, resulting in the inhibition of enzyme activity. The inhibition constant (K i, Cur  > K is,ZnO@rGO-Cur ) showed that the inhibition effect of ZnO@rGO-Cur on α-Glu was larger than that of Cur. The CCK-8 experiments proved that ZnO@rGO nanocomposites have good biocompatibility. These results suggest that the therapeutic potential of ZnO@rGO-Cur composite is an emerging nanocarrier platform for drug delivery systems for the potential treatment of diabetes mellitus., (© 2024 John Wiley & Sons Ltd.)