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BackgroundThere is an urgent need to better understand the factors that predict mental wellbeing in vocationally active adults during globally turbulent times.AimTo explore the relationship between psychological detachment from work (postulated as a key recovery activity from work) in the first national COVID-19 lockdown with health, wellbeing, and life satisfaction of working age-adults one year later, within the context of a global pandemic.MethodsWellbeing of the Workforce (WoW) was a prospective longitudinal cohort study, with two waves of data collection (Time 1, April-June 2020: T1 n = 337; Time 2, March-April 2021: T2 = 169) corresponding with the first and third national COVID-19 lockdowns in the UK. Participants were >18 years, who were employed or self-employed and working in the UK. Descriptive and parametric (t-tests and linear regression) and nonparametric (chi square tests) inferential statistics were employed.ResultsRisk for major depression (T1: 20.0% to T2: 29.0%, p = .002), poor general health (T1: 4.7% to T2: 0%, p = .002) and poor life satisfaction (T1: 15.4% to T2: 25.4%, p = .002) worsened over time, moderate-to-severe anxiety remained stable (T1: 26.1% to T2: 30.2%, p = .15). Low psychological detachment from work was more prevalent in the first wave (T1: 21.4% and T2: 16.0%), with a moderate improvement observed from T1 to T2 (t (129) = -7.09, p < .001). No differences were observed with work status (employed/self-employed), except for self-employed workers being more likely to report poor general health at T1 (16.1%, p = .002). Better psychological wellbeing, lower anxiety and higher life satisfaction at T2 were observed in those who reported better psychological detachment from work at T1 (β = .21, p = .01; β = -.43, p < .001; β = .32, p = .003, respectively), and in those who improved in this recovery activity from T1 to T2 (β = .36, p < .001; β = -.27, p < .001; β = .27, p = .008, respectively), controlling for age, gender and ethnicity.ConclusionThe ability to psychologically detach from work during the first pandemic lockdown, and improvement in this recovery activity over time, predicted better mental wellbeing and quality of life in vocationally active adults after one year of a global crisis, irrespective of work status. Interventions to encourage workers to psychologically detach from work may help to support employee wellbeing at all times, not only in the extreme circumstances of pandemics and economic uncertainty.

High efficiency CO 2 conversion materials are ideal for solar to carbon fuel conversion. Halide perovskite quantum dots (QDs) are highly desirable as catalysts and have been extensively investigated in the field of CO 2 photoreduction. The major challenge lies in the severe charge recombination and the weak ability to activate CO 2 . Herein, we have identified dispersed Ru nanoparticles anchored on CsPbBr 3 (CPB) QDs as prospective photocatalysts for CO 2 reduction at ambient pressure with light irradiation. The optimized 0.45 % CPB@Ru reduced CO 2 to CO at a rate of 28.12 μmol g -1  h -1 without any sacrificial agent and co-catalysts, about 4 times higher than that of the CPB QDs (7.03 μmol g -1  h -1 ). Experiments and DFT calculations reveal that the as-prepared CPB@Ru showed increased photogenerated charge separation, CO 2 adsorption/activation and lower energy barriers for the formation of *COOH intermediate, which are crucial for enhancing the photocatalytic CO 2 reduction activity. This work provides a convenient pathway for designing high-performance perovskite photocatalysts with high selectivity and high catalytic activity using metal nanoparticle loading technology., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025. Published by Elsevier Inc.)

The GLP-1 receptor, one of the most successful drug targets for the treatment of type 2 diabetes and obesity, is known to engage multiple intracellular signaling proteins. However, it remains less explored how the receptor interacts with proteins on the cell membrane. Here, we present a ligand-based proximity labeling approach to interrogate the native cell membrane interactome for the GLP-1 receptor after agonist simulation. Our study identified several unreported putative cell membrane interactors for the endogenous receptor in either a pancreatic β cell line or a neuronal cell line. We further uncovered new regulators of GLP-1 receptor-mediated signaling and insulinotropic responses in β cells. Additionally, we obtained a time-resolved cell membrane interactome map for the receptor in β cells. Therefore, our study provides a new approach that is generalizable to map endogenous cell membrane interactomes for G-protein-coupled receptors to decipher the molecular basis of their cell-type-specific functional regulation., Competing Interests: Competing interests: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)

The caudal nucleus of the solitary tract (cNTS) in the brainstem serves as a hub for integrating interoceptive cues from diverse sensory pathways. However, the mechanisms by which cNTS neurons transform these signals into behaviors remain debated. We analyzed 18 cNTS-Cre mouse lines and cataloged the dynamics of nine cNTS cell types during feeding. We show that Th + cNTS neurons encode esophageal mechanical distension and transient gulp size via vagal afferent inputs, providing quick feedback regulation of ingestion speed. By contrast, Gcg + cNTS neurons monitor intestinal nutrients and cumulative ingested calories and have long-term effects on food satiation and preference. These nutritive signals are conveyed through a portal vein-spinal ascending pathway rather than vagal sensory neurons. Our findings underscore distinctions among cNTS subtypes marked by differences in temporal dynamics, sensory modalities, associated visceral organs and ascending sensory pathways, all of which contribute to specific functions in coordinated feeding regulation., Competing Interests: Competing interests: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)

This paper presents an adaptive fast Fourier transform (adaptive FFT) demodulation scheme, aimed at enhancing the precision and noise suppression capability of signal processing in fiber-optic interferometric sensors. By adaptively optimizing the length of the acquired spectrum and dynamically adjusting the frequency domain resolution, the proposed scheme can precisely calculate the eigenfrequency of the reflected spectrum. Therefore, the adaptive FFT demodulation scheme can effectively enhance the extraction ability of phase quadrature demodulation signal. In comparison to traditional FFT demodulation scheme, the proposed scheme demonstrates nearly a tenfold improvement in eigenfrequency calculation accuracy. The experimental results indicate a significant improvement in the stability of the adaptive FFT demodulation scheme. The fluctuations are reduced to approximately 0.03 dB. This value is roughly equivalent to 25% of the fluctuations typically observed in traditional FFT demodulation schemes. Additionally, the adaptive FFT scheme demonstrates superior adaptability to sensors with varying optical path differences (OPDs). It maintains noise levels below -100 dB@1 kHz across sensors with different OPDs, and substantially reduces noise fluctuations compared to traditional FFT scheme. Furthermore, the proposed scheme exhibits notable advantages in crosstalk suppression for multiplexed signal demodulation. The fundamental frequency crosstalk (FFC) is reduced to below -50 dB, which is approximately 10 dB lower than that achieved by traditional FFT methods. The adaptive FFT demodulation scheme shows promising potential for applications in low noise, high precision, and dynamic signal detection within fiber-optic interferometer sensors and multiplexing arrays.