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6 results on '"Luo, Weibo"'

1. ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2

Author

Luo, Maowu, Bao, Lei, Xue, Yuanyuan, Zhu, Ming, Kumar, Ashwani, Xing, Chao, Wang, Jennifer E., Wang, Yingfei, and Luo, Weibo

Subjects
Thermo Fisher Scientific Inc., STEMCELL Technologies Inc., Scientific equipment and supplies industry, Stem cells, Antioxidants, Diagnostic reagents industry, Oxidative stress, Genetic transcription, Breast cancer, Health care industry
Abstract

Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase-high ([ALDH.sup.hi]) BCSCs, leading to BCSC expansion and tumor initiation in mice. The underlying mechanism involved a two-fold posttranslational regulation of nuclear factor erythroid 2-related factor 2 (NRF2). ZMYND8 increased stability of NRF2 protein through KEAP1 silencing. On the other hand, ZMYND8 interacted with and recruited NRF2 to the promoters of antioxidant genes to enhance gene transcription in mammospheres. NRF2 phenocopied ZMYND8 to enhance BCSC stemness and tumor initiation by inhibiting ROS and ferroptosis. Loss of NRF2 counteracted ZMYND8's effects on antioxidant genes and ROS in mammospheres. Interestingly, ZMYND8 expression was directly controlled by NRF2 in mammospheres. Collectively, these findings uncover a positive feedback loop that amplifies the antioxidant defense mechanism sustaining BCSC survival and stemness., Introduction Breast cancer stem cells (BCSCs) are defined as a subpopulation of tumor cells with capability of self renewal and long-term maintenance of breast tumors and are responsible for breast [...]

Published
2024
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2. Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

Author

Hu, Lianxin, Zhang, Yanfeng, Guo, Lei, Zhong, Hua, Xie, Ling, Zhou, Jin, Liao, Chengheng, Yao, Hongwei, Fang, Jun, Liu, Hongyi, Zhang, Cheng, Zhang, Hui, Zhu, Xiaoqiang, Luo, Maowu, von Kriegsheim, Alex, Li, Bufan, Luo, Weibo, Zhang, Xuewu, Chen, Xian, Mendell, Joshua T., Xu, Lin, Kapur, Payal, Baldwin, Albert S., Brugarolas, James, and Zhang, Qing

Published
2024
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3. Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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4. Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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5. Data from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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6. Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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