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Background: Mucorales and Aspergillus have invasive fungal infections with high mortality, mainly in immunocompromised and diabetic patients. The diagnosis is microbiological and pathological, with a strong clinical suspicion. The treatment is medical and surgical debridement. Invasive fungal coinfection by these two is reported as a case report. Here, we highlight the importance of considering the coinfection of Aspergillus and Mucor in the maxillary bone and paranasal sinuses in patients with systemic lupus erythematosus (SLE). Cases Report: A 38-year-old woman had a fever and toothache 1.5 months before and had been treated for a dental abscess, which continued to fever, epistaxis, teeth out spontaneously, left Bell's Palsy, and swelling in the left side of her face. She had a history of immunosuppressive therapy and steroid-induced hyperglycemia for SLE. The PNS CT Scan found increased mucosal thickness of the left maxilla and sphenoid sinuses. Extensive debridement was done. Pathologic study of debrided samples showed coinfection of invasive mucormycosis and aspergillosis. She was treated with liposomal amphotericin B and voriconazole with complete recovery without recurrence after a one-year follow-up. Conclusion: In mucor and aspergillus coinfection, no one should be missed at first and treated by specific antifungal amphotericin B, with no time-wasting for a better prognosis. [ABSTRACT FROM AUTHOR]

We investigated the transglycosylation reaction of two types of oligosaccharide acceptors, i.e., β-cyclodextrin (CD) derivatives 1 and 2 conjugated with multiple glucose (Glc) units, catalyzed by endo-β- N -acetyl-glucosaminidase from Mucor hiemalis (Endo-M) using the oligosaccharide donor sialoglycopeptide (SGP). The acceptor specificity of the enzyme transglycosylation of 1 and 2 having seven Glc moieties within small nanoscale spatial regions on the β-CDs was investigated on the basis of the effect of the molar ratios of SGP to acceptors 1 or 2 with different spatial configurations on the transglycosylation behavior. The formation of the corresponding CD-based oligosaccharide clusters from Endo-M was also evaluated. [Display omitted] • Endo-M transglycosylation to β-cyclodextrin derivatives with multiple glucose units. • Transglycosylation activity to glucose units with different spatial configurations. • Transglycosylation behavior by different molar ratios of donor/acceptor. • Synthesizing β-cyclodextrin-based oligosaccharide clusters. [ABSTRACT FROM AUTHOR]

Dry-aged beef is a premium product known for its unique taste and aroma. These characteristics are thought to partially depend on the composition of the microorganisms present on the meat surface during ageing. Recently several attempts to standardise this process were made. This study aimed to assess the effect of a fungal biostarter application on the profile of volatile compounds, fatty acid composition and sensory quality of dry-aged beef. The Longissimus muscle used in the experiment originated from 20 crossbred (10 heifers and 10 steers) animals from the crossing of Holstein-Friesian cows with beef breed bulls. A fungal biostarter composed of Mucor flavus strain KKP2092p was used for meat inoculation. Half of the material was aged without the use of a biostarter (Control samples). The dry-ageing of the meat was performed at a temperature of 1.5 °C with approximately 80-90 % relative humidity for 28 days. The use of Mucor flavus KKP2092p improved meat quality attributes (aroma liking, flavour and overall liking) as a result of the formation of specific volatile compounds. The profile of volatile compounds in the meat aged with Mucor flavus and control variants was differentiated. This study also indicated that Mucor flavus biostarter had an impact on the specific fatty acid composition. An insignificant effect of Mucor flavus on lipid oxidation expressed as mg/kg of malonaldehyde was also observed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)