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Background: Portal vein thrombosis (PVT) is a recognized complication of liver cirrhosis. The pathogenesis of PVT is multifactorial. The extent to which thrombophilia promotes PVT and whether patients with PVT should be routinely tested for thrombophilia remain uncertain. Objective: This retrospective research aimed to assess the frequency of thrombophilia in cirrhotic patients with non-malignant PVT to clarify the relevance of thrombophilia testing in this particular context. Patients and methods: This study involved 40 cirrhotic patients with protein C & S deficiency prior to liver transplantation, where 20 patients had PVT and the other group (20) had no PVT. Thrombophilia testing included gene analysis for beta-fibrinogen -455G>A, factor XIII V34L, factor V H1299R (R2), prothrombin G20210A, factor V Leiden, methylene tetrahydrofolate reductase (MTHFR) C677T, and MTHFR A1298C. Results: Regarding the thrombophilia gene screen, no statistically significant differences were detected between the two groups. In addition, the inherited thrombophilia gene status was not a risk factor for PVT. However, factor V Leiden showed a high odds ratio of 11.457 and 95% CI of 0.885 - 148.27. Conclusion: Inherited thrombophilia is considered to be a low-risk factor with low prevalence in patients with cirrhotic non-malignant PVT. Therefore, routine testing for these conditions does not seem to be indicated in this setting. [ABSTRACT FROM AUTHOR]

The study aims to explore the moderating effect of audit quality on the association between voluntary disclosure and profitability. The study sample consists of (34) industrial companies listed on the "Amman Stock Exchange (ASE) " during the period (2017-2021). To achieve the objectives of the study, the content analysis method has been used to measure the impact of voluntary disclosure by reviewing 32 items of voluntary disclosure. Several statistical methods that fit the objectives of the study are used as well. The results of the study show that there is a positive association between the voluntary disclosure level and the profitability of the company, and that the moderating variable of audit quality negatively affects the relationship between voluntary disclosure and the profitability of the company. Considering the aforesaid results, the study recommends making voluntary disclosure by the industrial companies listed on the "ASE" due to its role in enhancing the profitability of companies. [ABSTRACT FROM AUTHOR]