1. Diagnostic utility of brain MRI volumetry in comparing traumatic brain injury, Alzheimer disease and behavioral variant frontotemporal dementia
- Author
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Cyrus A. Raji, Somayeh Meysami, Verna R. Porter, David A. Merrill, and Mario F. Mendez
- Subjects
MRI volumetry ,Traumatic brain injury ,Alzheimer disease ,Dementia ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Brain MRI with volumetric quantification, MRI volumetry, can improve diagnostic delineation of patients with neurocognitive disorders by identifying brain atrophy that may not be evident on visual assessments. Objective To investigate diagnostic utility of MRI volumetry in traumatic brain injury (TBI), early-onset Alzheimer disease (EOAD), late-onset Alzheimer disease, and behavioral variant frontotemporal dementia (bvFTD). Method We utilized 137 participants of TBI (n = 40), EOAD (n = 45), LOAD (n = 32), and bvFTD (n = 20). Participants had 3D T1 brain MRI imaging amendable to MRI volumetry. Scan volumes were analyzed with Neuroreader. One-way ANOVA compared brain volumes across diagnostic groups. Discriminant analysis was done with leave-one-out cross validation on Neuroreader metrics to determine diagnostic delineation across groups. Result LOAD was the oldest compared to other groups (F = 27.5, p
- Published
- 2024
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