1. Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study
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Kelly Jones, Antonio Belli, Suzanne Polinder, Emmanuel Stamatakis, Hester F Lingsma, Dick Tibboel, Ronny Beer, Raimund Helbok, Horia Ples, Ari Ercole, Peter Cameron, Marek Czosnyka, Catherine McMahon, Peter Vajkoczy, Paul Dark, Alexandra Brazinova, Marek Majdan, Rahul Raj, William Stewart, Ewout W Steyerberg, Giuseppe Citerio, Nino Stocchetti, Alessia Vargiolu, Hester Lingsma, Helen Dawes, Benoit Misset, Faye Johnson, David van Klaveren, Simon Stanworth, Fiona Lecky, Peter Smielewski, Alice Theadom, Peter Bragge, David Nelson, János Sándor, Paul M Vespa, Olli Tenovuo, Olav Røise, Wim Van Hecke, Vincent Degos, David Menon, Bart Depreitere, Audny Anke, Rolf Rossaint, Mark Coburn, Victor Volovici, Daan Nieboer, Jonathan Rosand, Nada Andelic, Hans Clusmann, Emma Donoghue, Jonathan Coles, stefan jankowski, Jonathan Rhodes, Guy Williams, Rolf Lefering, Mathieu van der Jagt, Daniel Kondziella, Noah D Silverberg, Arturo Chieregato, Sophie Richter, Endre Czeiter, Stefan Winzeck, Jan Verheyden, András Büki, Benjamin Gravesteijn, Evgenios Kornaropoulos, Virginia Newcombe, Lindsay Wilson, Lindsay Horton, Amra Covic, Dominique Van Praag, Cecilia Åkerlund, Krisztina Amrein, Lasse Andreassen, Anna Antoni, Gérard Audibert, Philippe Azouvi, Ronald Bartels, Pál Barzó, Romuald Beauvais, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Guillermo Carbayo Lozano, Marco Carbonara, Simona Cavallo, Giorgio Chevallard, Marta Correia, Nicola Curry, Véronique De Keyser, Hugo den Boogert, Đula Đilvesi, Abhishek Dixit, Jens Dreier, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Jagoš Golubovic Ben Glocker, Johannes Gratz, Francesca Grossi, Deepak Gupta, Iain Haitsma, Eirik Helseth, Jilske Huijben, Bram Jacobs, Mike Jarrett, Mladen Karan, Erwin Kompanje, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Didier Ledoux, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Marc Maegele, Alex Manara, Geoffrey Manley, Costanza Martino, Hugues Maréchal, Julia Mattern, Béla Melegh, Tomas Menovsky, Ana Mikolic, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, József Nyirádi, Otesile Olubukola, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M Parizel, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Matti Pirinen, Inigo Pomposo, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Malinka Rambadagalla, Sylvia Richardson, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Christina Rosenlund, Guy Rosenthal, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Abayomi Sorinola, Robert Stevens, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Matt Thomas, Marjolein Timmers, Christos Tolias, Tony Trapani, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Emmanuel Vega, Kimberley Velt, Anne Vik, Rimantas Vilcinis, Daphne Voormolen, Petar Vulekovic, Kevin K W Wang, Eveline Wiegers, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A Zeiler, Veronika Zelinkova, Agate Ziverte, Tommaso Zoerle, Joukje van der Naalt, Braden Te Ao, Caroline van Heugten, Francesco Della Corte, Ernest Van Veen, Andrew IR Maas, Andreas Unterberg, Thomas A van Essen, Mathilde Jost, Shuyuan Shi, Maria Luisa Azzolini, Maria Rosa Calvi, Jamie D Cooper, Claire Dahyot Fizelier, Guy Loup Dulière, Valery L Feigin, Pedro A Gomez, Russell L Gruen, Juanita A Haagsma, Peter J Hutchinson, Ji yao Jiang, Angelos G Kolias, Lars Owe Koskinen, Andrew I Z Maas, Ana M Castaño León, Jean François Payen, Anna Piippo Karjalainen, Dana Pisica, Jussi PPosti, Isabel Retel Helmrich, Jeffrey VRosenfeld, Daniel Rueckert Martin Rusnák, Renan SanchezPorras, Rico Frederik Schou, Cristina Maria Tudora, Gregory Van der Steen, Jeroen T J M van Dijck, Thijs Vande Vyvere, Roel P J van Wijk, and Nicole von Steinbüchel
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Psychiatry ,RC435-571 - Abstract
Background Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression and PTSD symptoms at 6 months post-TBI.Methods We analysed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. We used linear regression to model the relationship between predictors and depression (Patient Health Questionnaire-9) and PTSD symptoms (PTSD Checklist for Diagnostic and Statistical Manual for Mental Health Disorders Fifth Edition). Predictors were selected based on Akaike’s Information Criterion. Additionally, we fitted logistic models for the endpoints ‘probable MDD’ and ‘probable PTSD’. We also examined the incremental prognostic value of 2–3 weeks of symptoms.Results We included 2163 adults (76% Glasgow Coma Scale=13–15). Depending on the scoring criteria, 7–18% screened positive for probable MDD and about 10% for probable PTSD. For both outcomes, the selected models included psychiatric history, employment status, sex, injury cause, alcohol intoxication and total injury severity; and for depression symptoms also preinjury health and education. The performance of the models was modest (proportion of explained variance=R2 8% and 7% for depression and PTSD, respectively). Symptoms assessed at 2–3 weeks had a large incremental prognostic value (delta R2=0.25, 95% CI 0.24 to 0.26 for depression symptoms; delta R2=0.30, 95% CI 0.29 to 0.31 for PTSD).Conclusion Preinjury characteristics, such as psychiatric history and unemployment, and injury characteristics, such as violent injury cause, can increase the risk of mental health problems after TBI. The identification of patients at risk should be guided by early screening of mental health.
- Published
- 2025
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