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Your search keyword '"McMillan, David"' showing total 7 results
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7 results on '"McMillan, David"'

2. Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Author

Xie, Ouli, primary, Morris, Jacqueline M., additional, Hayes, Andrew J., additional, Towers, Rebecca J., additional, Jespersen, Magnus G., additional, Lees, John A., additional, Ben Zakour, Nouri L., additional, Berking, Olga, additional, Baines, Sarah L., additional, Carter, Glen P., additional, Tonkin-Hill, Gerry, additional, Schrieber, Layla, additional, McIntyre, Liam, additional, Lacey, Jake A., additional, James, Taylah B., additional, Sriprakash, Kadaba S., additional, Beatson, Scott A., additional, Hasegawa, Tadao, additional, Giffard, Phil, additional, Steer, Andrew C., additional, Batzloff, Michael R., additional, Beall, Bernard W., additional, Pinho, Marcos D., additional, Ramirez, Mario, additional, Bessen, Debra E., additional, Dougan, Gordon, additional, Bentley, Stephen D., additional, Walker, Mark J., additional, Currie, Bart J., additional, Tong, Steven Y. C., additional, McMillan, David J., additional, and Davies, Mark R., additional

Published
2024
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7. Spinal Cord Injury Associated Disease of the Skeleton, an Unresolved Problem with Need for Multimodal Interventions.

Author

Echevarria-Cruz E, McMillan DW, Reid KF, and Valderrábano RJ

Abstract

Spinal cord injury is associated with skeletal unloading, sedentary behavior, decreases in skeletal muscle mass, and exercise intolerance, which results in rapid and severe bone loss. To date, monotherapy with physical interventions such as weight-bearing in standing frames, computer-controlled electrically stimulated cycling and ambulation exercise, and low-intensity vibration are unsuccessful in maintaining bone density after SCI. Strategies to maintain bone density with commonly used osteoporosis medications also fail to provide a significant clinical benefit, potentially due to a unique pathology of bone deterioration in SCI. In this review, the available data is discussed on evaluating and monitoring bone loss, fracture, and physical and pharmacological therapeutic approaches to SCI-associated disease of the skeleton. The treatment of SCI-associated disease of the skeleton, the implications for clinical management, and areas of need are considered for future investigation., (© 2024 Wiley‐VCH GmbH.)

Published
2024
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