18 results on '"Meng, Lu"'
Search Results
2. Prone position ventilation for the relief of acute respiratory distress syndrome through improved pulmonary ventilation: Efficacy and safety.
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Liao, Xianyong, Meng, Lu, and Zeng, Zhongyi
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MEDICAL information storage & retrieval systems , *ADULT respiratory distress syndrome , *PATIENT safety , *RESEARCH funding , *LYING down position , *HOSPITAL care , *TREATMENT effectiveness , *HOSPITAL mortality , *SYSTEMATIC reviews , *MEDLINE , *NURSING services administration , *REACTIVE oxygen species , *OXYGEN in the body , *ARTIFICIAL respiration , *MEDICAL databases , *ONLINE information services , *PUBLICATION bias - Abstract
Background: At present, there is a preliminary clinical consensus that prone position ventilation (PPV) is beneficial to the treatment of acute respiratory distress syndrome (ARDS), and further research on the details of treatment and patients' benefits will help to assess its effectiveness and safety. Aim: To evaluate the timing, efficacy, and safety of different mechanical ventilation positions (MVP) in treating ARDS. Study Design: The results of clinical trials were directly or indirectly compared by network meta‐analysis to compare the effects of different MVP. Two authors independently searched the papers published in PubMed, Embase, Cochrane Library, China Knowledge Infrastructure (CNKI), China Biomedical Discs (CBM), WanFang, and VIP database from January 2000 to August 2022. The outcome indicators were oxygenation index, mechanical ventilation time, ICU hospitalization time, in‐hospital mortality, and incidence of adverse events. Two authors independently screened the literature, evaluated the quality of the studies, and completed the data extraction. Stata 14.0 was used to conduct a network Meta‐analysis, and the intervention measures were ranked according to the surface under the cumulative ranking curve (SUCRA). Funnel plots were drawn to evaluate publication bias. Results: According to the inclusion and exclusion criteria, 75 studies (including 6333 patient data) were finally included. According to the analysis results, PPV was the best for improving the oxygenation index. The SUCRA values of mechanical ventilation time, ICU hospitalization time, and in‐hospital mortality were ranked as PPV > lateral position ventilation (LPV) > supine position ventilation (SuPV) > semireclining position ventilation (SePV). The SUCRA values in the incidence of adverse events were ranked as LPV > PPV > SuPV > SePV. All outcome measures had good consistency and low statistical heterogeneity. Funnel plot analysis shows that papers reported within three days of mechanical ventilation time, over five days of mechanical ventilation time, and in‐hospital mortality were more likely to have publication bias. Conclusions: PPV has the best effect on improving the oxygenation index, reducing mechanical ventilation time, shortening ICU hospitalization time, and reducing in‐hospital mortality. Early and long‐term use of PPV to improve pulmonary ventilatory function will be the key to improving patients' survival and quality of life with ARDS. Relevance to clinical practice: PPV significantly affects patients with ARDS, which can shorten the treatment time and reduce hospital costs. During the treatment, nursing observation should be strengthened to prevent adverse events. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Circ_0002395 promotes aerobic glycolysis and proliferation in pancreatic adenocarcinoma cells via miR-548c-3p/PDK1 axis.
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Shu, Meng-lu, Xia, Jun-kai, Yan, Jing, Feng, Yu-jie, Qian, Cui-juan, Teng, Xiao-sheng, and Yao, Jun
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GLYCOLYSIS , *GENE expression , *CIRCULAR RNA , *LYMPHATIC metastasis , *ADENOCARCINOMA - Abstract
Circular RNAs (circRNAs) showing unusual expressions have been discovered in pancreatic adenocarcinoma (PAAD). However, the functions and underlying mechanisms of these circRNAs still remain largely unclear. Our current study discovered a notable increase in the expression of circRNA hsa_circ_0002395 (circ_0002395) in both PAAD tissues and cell lines. This up-regulation of circ_0002395 was found to be associated with larger tumor sizes and lymph node metastasis. Furthermore, our findings showed that circ_0002395 facilitated aerobic glycolysis and cell proliferation in PAAD cells by regulating the miR-548c-3p/PDK1 axis. Mechanistically, we identified circ_0002395 as a competing endogenous RNA (ceRNA) that sponged miR-548c-3p, thereby promoting PDK1 expression and aerobic glycolysis, and ultimately resulting in the enhancement of cell proliferation. Our findings found that circ_0002395 promoted proliferation of PAAD cells by enhancing PDK1 expression and aerobic glycolysis by sponging miR-548c-3p. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Hydroxyl-containing triazine-based conjugated microporous polymers for solid phase extraction of fluoroquinolone antibiotics in the environment and food samples.
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Meng, Lu-Shu, Wang, Xiao-Li, Wang, Xia, Ji, Lei, Wang, Lei-Lei, Cai, Ya-Qi, and Zhao, Ru-Song
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SOLID phase extraction , *CONJUGATED polymers , *LIQUID chromatography-mass spectrometry , *ENVIRONMENTAL monitoring , *HYDROGEN bonding , *ENVIRONMENTAL sampling , *ANTIBIOTICS - Abstract
[Display omitted] • A hydroxyl-containing triazine-based conjugated microporous polymers was facilely synthesized. • The material showed high adsorption efficiency for fluoroquinolones. • Hydrogen bonding and π-π interactions dominate the extraction. • The proposed method was successfully achieved in environmental and food samples. Fluoroquinolones (FQs) are a category of broadly used antibiotics. Development of an effective and sensitive approach for determination of trace FQs in environmental and food samples is still challenging. Herein, the hydroxyl-containing triazine-based conjugated microporous polymers (CMPs-OH) was constructed and served as SPE absorbent for the efficient enrichment of FQs. Based on DFT simulations, the excellent enrichment capacity between CMPs-OH and FQs was contributed by hydrogen bonding and π-π interactions. In combination with high-performance liquid chromatography-tandem mass spectrometry, the proposed approach exhibited a wide linear range (0.2–400 ng L−1), low detection limits (0.05–0.15 ng L−1), and good intraday and interday precisions under optimal conditions. In addition, the established method was effectively utilized for the determination of FQs in fourteen samples with recoveries between 82.6 % and 109.2 %. This work provided a feasible sample pretreatment method for monitoring FQs in environmental and food matrices. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring.
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Li, Hong-Bao, Xu, Meng-Lu, Xia, Wen-Jie, Dong, Yuan-Yuan, Peng, Bo, Su, Qing, Wang, Xiao-Min, Yu, Jia-Yue, Gao, Ya-Nan, Wu, Jun-Zhe, Xu, Meng-Yue, Yang, Jin-Bao, Dai, Zhi-Ming, Chen, Lei, Li, Ying, and Bai, Juan
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ATTENTION-deficit hyperactivity disorder , *GUT microbiome , *CONTINUOUS performance test , *BRAIN-derived neurotrophic factor , *GESTATIONAL diabetes , *MENTAL illness , *CAPTOPRIL - Abstract
The pathogenesis of attention-deficit/hyperactivity disorder (ADHD) has not been fully elucidated. Gestational hypertension could double the probability of ADHD in the offspring, while the initial bacterial communication between the mother and offspring has been associated with psychiatric disorders. Thus, we hypothesize that antihypertensive treatment during pregnancy may abate the impairments in neurodevelopment of the offspring. To test this hypothesis, we chose Captopril and Labetalol, to apply to pregnant spontaneously hypertensive rat (SHR) dams and examined the outcomes in the male offspring. Our data demonstrated that maternal treatment with Captopril and Labetalol had long-lasting changes in gut microbiota and behavioral alterations, including decreased hyperactivity and increased curiosity, spatial learning and memory in the male offspring. Increased diversity and composition were identified, and some ADHD related bacteria were found to have the same change in the gut microbiota of both the dam and offspring after the treatments. LC-MS/MS and immunohistochemistry assays suggested elevated expression of brain derived neurotrophic factor (BDNF) and dopamine in the prefrontal cortex and striatum of offspring exposed to Captopril/ Labetalol, which may account for the improvement of the offspring's psychiatric functions. Therefore, our results support the beneficial long-term effects of the intervention of gestational hypertension in the prevention of ADHD. [Display omitted] • Maternal Captopril/Labetalol treatment alleviated ADHD symptoms in SHR offspring. • Maternal Captopril/Labetalol treatment altered gut microbiota in SHR offspring. • Maternal Captopril/Labetalol treatment elevated brain dopamine in SHR offspring. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Parental Perfectionist Expectations and Online Gaming Addiction in Chinese Undergraduates: A Serial Mediating Model of Trait Anxiety and Perceived Stress and the Moderating Role of Flow Experience.
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Meng, Yayun, Meng, Lu, Li, Jiarui, Liu, Guangzeng, Zheng, Sufang, and He, Jinbo
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The current study developed a moderated mediation model to investigate the effects of parental perfectionist expectations on online gaming addiction and its underlying mechanisms among Chinese undergraduates. 6403 Chinese undergraduates from Guangxi and Sichuan (51.0% males, mean age = 19.17 years) consented to take part in the study. The findings revealed that trait anxiety and perceived stress significantly mediated the relationship between parental perfectionist expectations and online gaming addiction. Moreover, flow experience moderated the effects of parental perfectionist expectations and trait anxiety on online gaming addiction, and this relationship was stronger with higher flow experience. These findings underscore the importance of a relatively comprehensive approach that takes into account both parental and individual factors when designing prevention and intervention strategies for online gaming addiction. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Comparison of factors associated with seasonal influenza and COVID-19 booster vaccination coverage among healthcare personnel working at acute care hospitals during 2021–2022 influenza season, National Healthcare Safety Network, United States.
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Meng, Lu, Bell, Jeneita, Soe, Minn, Edwards, Jonathan, Lymon, Hoody, Barbre, Kira, Reses, Hannah, Patel, Avni, Wong, Emily, Dudeck, Margaret, Huynh, Cam-Van, Rowe, Theresa, Dubendris, Heather, and Benin, Andrea
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MEDICAL personnel , *SEASONAL influenza , *BOOSTER vaccines , *VACCINATION coverage , *COVID-19 vaccines , *ACUTE care nurse practitioners , *VACCINATION - Abstract
The simultaneous circulation of seasonal influenza virus and SARS-CoV-2 variants will likely pose unique challenges to public health during the future influenza seasons. Persons who are undergoing treatment in healthcare facilities may be particularly at risk. It is important for healthcare personnel to protect themselves and patients by receiving vaccines. The purpose of this study is to assess coverage of the seasonal influenza vaccine and COVID-19 monovalent booster among healthcare personnel working at acute care hospitals in the United States during the 2021–22 influenza season and to examine the demographic and facility characteristics associated with coverage. A total of 3260 acute care hospitals with over 7 million healthcare personnel reported vaccination data to National Healthcare Safety Network (NHSN) during the 2021–22 influenza season. Two separate negative binomial mixed models were developed to explore the factors associated with seasonal influenza coverage and COVID-19 monovalent booster coverage. At the end of the 2021–2022 influenza season, the overall pooled mean seasonal influenza coverage was 80.3%, and the pooled mean COVID-19 booster coverage was 39.5%. Several demographic and facility-level factors, such as employee type, facility ownership, and geographic region, were significantly associated with vaccination against influenza and COVID-19 among healthcare personnel working in acute care hospitals. Our findings highlight the need to increase the uptake of vaccination among healthcare personnel, particularly non-employees, those working in for-profit and non-medical school-affiliated facilities, and those residing in the South. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Sandwich structure silver nanowires transparent conductive films with improved photoelectronic performance.
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Yao, Wang, Yuxin, Tang, Meng, Lu, Hanming, Ding, Demei, Kong, and Dezeng, Li
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SANDWICH construction (Materials) , *NANOWIRES , *INDIUM tin oxide , *ANTIREFLECTIVE coatings , *CONTACT angle , *SILVER , *STRUCTURAL stability , *GRAPHENE oxide - Abstract
Silver nanowires (AgNWs) are a promising substitute for indium tin oxide (ITO) transparent conductive films (TCFs). However, AgNWs suffer the insufficiencies in contact resistance between the nanowires and light loss. Here, graphene oxide and moth-eye-like antireflection nanostructure have been introduced to physically "weld" the AgNWs junctions and modulate the AR properties, respectively. The sandwich structure AgNWs TCFs achieved resistance of 26.26 Ω sq−1 and transmittance of 98.67%, exhibiting promoted photoelectronic performance compared with the pure AgNWs films. The stability of sandwich structure AgNWs TCFs was improved, and their wettability was also discussed with water contact angle changed from 92.55° to 69.18°, switched from hydrophobic to hydrophilic. Though a simple solution process without mechanical or heat post-treatment, we proposed a stable sandwich structure to obviously improve the electrical and optical capabilities of AgNWs. The enhanced AgNWs TCFs with superior photoelectronic performance are believed to boost the practical applications and future development of AgNWs-based TCFs. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
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Rao, Dongning, Li, Jiaxin, Zhang, Mao, Huang, Siyuan, Meng, Lu, Song, Guohe, Ma, Jiaqiang, Wu, Yingcheng, Cheng, Yifei, Ji, Shuyi, Wu, Gaohua, Chen, Lv, Liu, Yuming, Shi, Yang, Zhou, Jian, Jia, Fan, Zhang, Xiaoming, Xi, Ruibin, and Gao, Qiang
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NEUTROPHILS , *BILIARY tract , *LIVER , *RNA sequencing , *GALLBLADDER cancer , *CYTOTOXINS - Abstract
Background: Gallbladder cancer (GBC) is the most common and lethal malignancy of the biliary tract that lacks effective therapy. In many GBC cases, infiltration into adjacent organs or distant metastasis happened long before the diagnosis, especially the direct liver invasion, which is the most common and unfavorable way of spreading. Methods: Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), proteomics, and multiplexed immunohistochemistry (mIHC) were performed on GBC across multiple tumor stages to characterize the tumor microenvironment (TME), focusing specifically on the preferential enrichment of neutrophils in GBC liver invasion (GBC-LI). Results: Multi-model Analysis reveals the immunosuppressive TME of GBC-LI that was characterized by the enrichment of neutrophils at the invasive front. We identified the context-dependent transcriptional states of neutrophils, with the Tumor-Modifying state being associated with oxidized low-density lipoprotein (oxLDL) metabolism. In vitro assays showed that the direct cell-cell contact between GBC cells and neutrophils led to the drastic increase in oxLDL uptake of neutrophils, which was primarily mediated by the elevated OLR1 on neutrophils. The oxLDL-absorbing neutrophils displayed a higher potential to promote tumor invasion while demonstrating lower cancer cytotoxicity. Finally, we identified a neutrophil-promoting niche at the invasive front of GBC-LI that constituted of KRT17+ GBC cells, neutrophils, and surrounding fibroblasts, which may help cultivate the oxLDL-absorbing neutrophils. Conclusions: Our study reveals the existence of a subset of pro-tumoral neutrophils with a unique ability to absorb oxLDL via OLR1, a phenomenon induced through cell-cell contact with KRT17+ GBC cells in GBC-LI. [ABSTRACT FROM AUTHOR]
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- 2024
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10. All in the Family? A Systematic Review and Meta-analysis of Parenting and Family Environment as Risk Factors for Attention-Deficit/Hyperactivity Disorder (ADHD) in Children.
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Claussen, Angelika H., Holbrook, Joseph R., Hutchins, Helena J., Robinson, Lara R., Bloomfield, Jeanette, Meng, Lu, Bitsko, Rebecca H., O'Masta, Brenna, Cerles, Audrey, Maher, Brion, Rush, Margaret, and Kaminski, Jennifer W.
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ATTENTION-deficit hyperactivity disorder , *HOME environment , *MEDIA exposure , *PARENTING , *PARENT imprisonment - Abstract
Parenting and family environment have significant impact on child development, including development of executive function, attention, and self-regulation, and may affect the risk of developmental disorders including attention-deficit/hyperactivity disorder (ADHD). This paper examines the relationship of parenting and family environment factors with ADHD. A systematic review of the literature was conducted in 2014 and identified 52 longitudinal studies. A follow-up search in 2021 identified 7 additional articles, for a total of 59 studies that examined the association of parenting factors with ADHD outcomes: ADHD overall (diagnosis or symptoms), ADHD diagnosis specifically, or presence of the specific ADHD symptoms of inattention and hyperactivity/impulsivity. For parenting factors that were present in three or more studies, pooled effect sizes were calculated separately for dichotomous or continuous ADHD outcomes, accounting for each study's conditional variance. Factors with sufficient information for analysis were parenting interaction quality (sensitivity/warmth, intrusiveness/reactivity, and negativity/harsh discipline), maltreatment (general maltreatment and physical abuse), parental relationship status (divorce, single parenting), parental incarceration, and child media exposure. All factors showed a significant direct association with ADHD outcomes, except sensitivity/warmth which had an inverse association. Parenting factors predicted diagnosis and overall symptoms as well as inattentive and hyperactive symptoms when measured, but multiple factors showed significant heterogeneity across studies. These findings support the possibility that parenting and family environment influences ADHD symptoms and may affect a child's likelihood of being diagnosed with ADHD. Prevention strategies that support parents, such as decreasing parenting challenges and increasing access to parent training in behavior management, may improve children's long-term developmental health. [ABSTRACT FROM AUTHOR]
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- 2024
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11. PD‐L1 inhibitors combined with whole brain radiotherapy in patients with small cell lung cancer brain metastases: Real‐world evidence.
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Huang, Litang, Chen, Shen, Liu, Hui, Meng, Lu, Liu, Chengxing, Wu, Xiaoting, Wang, Yingying, Luo, Shilan, Tu, Hongbin, Wang, Chunlei, Zhang, Ming, and Gong, Xiaomei
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SMALL cell lung cancer , *BRAIN cancer , *METASTASIS , *IMMUNE checkpoint inhibitors , *PROGRAMMED death-ligand 1 - Abstract
Background: Numerous studies have demonstrated that brain metastases patients may benefit from intracranial radiotherapy combined with immune checkpoint inhibitors (ICIs). However, it is unclear whether this treatment is effective for patients with small cell lung cancer brain metastases (SCLC‐BMs). Methods: We conducted a retrospective study by analyzing medical records of patients with SCLC‐BMs from January 1, 2017 to June 1, 2022. Data related to median overall survival (mOS), median progression‐free survival (mPFS), and intracranial progression‐free survival (iPFS) were analyzed. Results: A total of 109 patients were enrolled, of which 60 received WBRT and 49 received WBRT‐ICI. Compared to the WBRT alone cohort, the WBRT‐ICI cohort showed longer mOS (20.4 months vs. 29.3 months, p = 0.021), mPFS (7.9 months vs. 15.1 months, p < 0.001), and iPFS (8.3 months vs. 16.5 months, p < 0.001). Furthermore, WBRT‐ICI cohort had a better response rate for both BMs. (p = 0.035) and extracranial diseases (p < 0.001) compared to those receiving WBRT alone. Notably, the use of WBRT before ICI was associated with longer mOS compared to the use of WBRT after ICI (23.3 months for the ICI‐WBRT group vs. 34.8 months for the WBRT‐ICI group, p = 0.020). Conclusion: Our results indicated that WBRT combined with immunotherapy improved survival in SCLC‐BMs patients compared to WBRT monotherapy. Administering WBRT prior to ICI treatment is associated with improved survival outcomes compared to WBRT following ICI treatment, for patients with SCLC‐BMs. These findings highlight the significance of conducting further prospective researches on combination strategies of intracranial radiotherapy and ICI in SCLC‐BMs patients. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Molecular Insights into the Specific Targeting of c-MYC G-Quadruplex by Thiazole Peptides.
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Cao, Sen, Su, Qian, Chen, Yong-Hao, Wang, Meng-Lu, Xu, Yi, Wang, Li-Hui, Lu, Yan-Hua, Li, Jian-Feng, Liu, Jun, Hong, Xiao-Jing, Wang, Hong-Yan, Liu, Jun-Ping, and Wang, Zhi-Guo
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MOLECULAR docking , *MOLECULAR dynamics , *QUADRUPLEX nucleic acids , *GENE expression , *PEPTIDES , *MOLECULAR motor proteins , *THIAZOLES , *BINDING energy - Abstract
Stabilization of a G-quadruplex (G4) in the promotor of the c-MYC proto-oncogene leads to inhibition of gene expression, and it thus represents a potentially attractive new strategy for cancer treatment. However, most G4 stabilizers show little selectivity among the many G4s present in the cellular complement of DNA and RNA. Intriguingly, a crescent-shaped cell-penetrating thiazole peptide, TH3, preferentially stabilizes the c-MYC G4 over other promotor G4s, but the mechanisms leading to this selective binding remain obscure. To investigate these mechanisms at the atomic level, we performed an in silico comparative investigation of the binding of TH3 and its analogue TH1 to the G4s from the promotors of c-MYC, c-KIT1, c-KIT2, and BCL2. Molecular docking and molecular dynamics simulations, combined with in-depth analyses of non-covalent interactions and bulk and per-nucleotide binding free energies, revealed that both TH3 and TH1 can induce the formation of a sandwich-like framework through stacking with both the top and bottom G-tetrads of the c-MYC G4 and the adjacent terminal capping nucleotides. This framework produces enhanced binding affinities for c-MYC G4 relative to other promotor G4s, with TH3 exhibiting an outstanding binding priority. Van der Waals interactions were identified to be the key factor in complex formation in all cases. Collectively, our findings fully agree with available experimental data. Therefore, the identified mechanisms leading to specific binding of TH3 towards c-MYC G4 provide valuable information to guide the development of new selective G4 stabilizers. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Dendrobium officinale phenolic extract maintains proteostasis by regulating autophagy in a Caenorhabditis elegans model of Alzheimer's disease.
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Yu, Ying-Ting, Lin, Hong-Ru, Chen, Xin-Yan, Sun, Meng-Lu, Wei, Cong-Min, Xue, Meng-Fan, Gao, Yi-Huai, Tang, Wen-Bo, Zheng, Chun-Yuan, Li, Shan, and Wang, Hong-Bing
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CHINESE medicine , *PROTEINS , *TAU proteins , *ALZHEIMER'S disease , *HOMEOSTASIS , *AUTOPHAGY , *LIQUID chromatography-mass spectrometry , *HERBAL medicine , *CELLULAR signal transduction , *REVERSE transcriptase polymerase chain reaction , *PLANT extracts , *DOSE-effect relationship in pharmacology , *RNA , *PHENOLS , *ANIMAL experimentation , *CAENORHABDITIS elegans , *SEQUENCE analysis - Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and accumulating evidence suggested that proteostatic imbalance is a key feature of the disease. Traditional Chinese medicine exhibits a multi-target therapeutic effect, making it highly suitable for addressing protein homeostasis imbalance in AD. Dendrobium officinale is a traditional Chinese herbs commonly used as tonic agent in China. In this study, we investigated protection effects of D. officinale phenolic extract (SH-F) and examined its underlying mechanisms by using transgenic Caenorhabditis elegans models. We found that treatment with SH-F (50 μg/mL) alleviated Aβ and tau protein toxicity in worms, and also reduced aggregation of polyglutamine proteins to help maintain proteostasis. RNA sequencing results showed that SH-F treatment significantly affected the proteolytic process and autophagy–lysosomal pathway. Furthermore, we confirmed that SH-F showing maintainance of proteostasis was dependent on bec-1 by qRT-PCR analysis and RNAi methods. Finally, we identified active components of SH-F by LC-MS method, and found the five major compounds including koaburaside, tyramine dihydroferulate, N-p-trans-coumaroyltyramine, naringenin and isolariciresinol are the main bioactive components responsible for the anti-AD activity of SH-F. Our findings provide new insights to develop a treatment strategy for AD by targeting proteostasis, and SH-F could be an alternative drug for the treatment of AD. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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14. G-CSF improving combined whole brain radiotherapy and immunotherapy prognosis of non-small cell lung cancer brain metastases.
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Luo, Shilan, Li, Peng, Zhang, Anqi, Meng, Lu, Huang, Litang, Wu, Xiaoting, Cheng, Hongxia, Tu, Hongbin, and Gong, Xiaomei
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NON-small-cell lung carcinoma , *BRAIN cancer , *METASTASIS , *LUNGS , *PROGNOSIS , *IMMUNOTHERAPY - Abstract
• G-CSF to WBRT + ICIs as a first-line treatment prolonged OS of NSCLC brain metastases. • G-CSF may improve neurological symptoms in patients undergoing WBRT. • G-CSF effectively reduced the incidence of neutropenia after ICIs, further preventing severe infections. To evaluate the therapeutic advantage of G-CSF to whole brain radiotherapy (WBRT) in combination with immunotherapy as a first-line treatment for non-small cell lung cancer (NSCLC) brain metastases (BMs). In this retrospective study, 117 patients (37 in G-CSF group and 80 in no G-CSF group) who underwent first-line WBRT combined with immunotherapy were enrolled. Their survival, intracranial response, BM-related symptoms and toxicity were evaluated. The overall survival (OS) of patients in G-CSF group was significantly improved compared to patients no G-CSF group (median time: 14.8 vs 10.2 months; HR: 0.61, 95 % CI: 0.38–0.97, p = 0.035). However, there were no significant differences in intracranial responses between the two groups (p > 0.05). The G-CSF group exhibited a significantly higher rate of relief from BM-related symptoms compared to the no G-CSF group (91.7 % vs 59.5 %, p = 0.037). Cox proportional hazards regression analyses indicated that after-treatment ALC > 0.9 × 10^9/L (HR 0.57, 95 % CI 0.32–0.99, p = 0.046) and Hb > 110 g/dL (HR 0.41, 95 % CI 0.24–0.71, p = 0.001) were significant potential factors associated with extended OS. The addition of G-CSF was well tolerated and effectively reduced the incidence of neutropenia (0 % vs 5.0 %, p = 0.17). Integrating G-CSF with WBRT and immunotherapy as a first-line treatment for NSCLC-BMs has exhibited significant efficacy and favorable tolerability. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Inverse effects of aerosol radiative forcing on heavy PM2.5 pollution of local accumulation and regional transport over Central China.
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Sun, Xiaoyun, Zhao, Tianliang, Hu, Jun, Bai, Yongqing, Meng, Lu, Yang, Qingjian, Zhou, Yue, and Fu, Weikang
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- 2024
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16. Terrain effects of the Tibetan Plateau on dust aerosol distribution over the Tarim Basin, China.
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Zhou, Chenglong, Yang, Xinghua, Liu, Yuzhi, Zhu, Qingzhe, Xie, Yongkun, Yang, Fan, Ali, Mamtimn, Huo, Wen, He, Qing, and Meng, Lu
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DUST , *MINERAL dusts , *ATMOSPHERIC boundary layer , *AEROSOLS , *CHEMICAL models , *ATMOSPHERIC layers , *METEOROLOGICAL research - Abstract
Dust events are frequent in the Tarim Basin because of its underlying desert surface; moreover, meteorological conditions under the influence of the surrounding high terrains, especially the Tibetan Plateau, may also trigger dust events. However, the terrain effect of the Tibetan Plateau on the dust aerosol distribution over the Tarim Basin remains unclear. This study aimed to investigate the impact of the Tibetan Plateau terrain on the dust aerosol variations in three dust events over the Tarim Basin using the Weather Research and Forecasting Chemistry model. With decreasing altitude of the Tibetan Plateau, dust concentration (DC) decreased in the upper layers and increased in the low layers. The DC within the entire atmospheric layers increased by 8.52%, 24.03%, and 43.05% on average during three dust events at Tibetan Plateau altitudes of 3000 m, 2000 m, and 1000 m, respectively, thereby indicating that the DC in the lower layers increasingly dominated the entire atmospheric layers as the Tibetan Plateau altitude decreased. Low-elevation terrain enhanced the planetary boundary layer height, near-surface wind speed, and surface air temperature, but weakened atmospheric stratification stability, all of which are beneficial for strengthening dust emissions and vertical mixing in the lower layers of the Tarim Basin. Furthermore, a decrease in the Tibetan Plateau altitude led to forming a vertical circulation, with the south to rise and the north to sink over the Tarim Basin. Meteorological field and vertical circulation could adequately explain the changes in the distribution of dust aerosols over the Tarim Basin. Overall, this study enhances our understanding of the effect of the Tibetan Plateau terrain on changes in the dust aerosol in the Tarim Basin and surrounding central Asian regions. [Display omitted] • Tibetan Plateau altitude decreased leads to less DC of the upper layers and more DC in the low layers over the Tarim Basim; • DC in the lower layers increasingly dominated the entire atmospheric layers with the Tibetan Plateau altitude decreased. • Meteorological field and vertical circulation commonly cause the change of dust aerosols distribution over the Tarim Basim. [ABSTRACT FROM AUTHOR]
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- 2024
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17. A direct FE[formula omitted] method for concurrent multilevel modeling of piezoelectric materials and structures.
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Li, Haozhi, Chen, Leilei, Zhi, Geng, Meng, Lu, Lian, Haojie, Liu, Zhaowei, Yu, Tiantang, and Li, Pei
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PIEZOELECTRIC materials , *MULTILEVEL models , *ELECTRIC displacement , *HONEYCOMB structures , *MULTISCALE modeling , *PIEZOELECTRIC composites - Abstract
Multiscale piezoelectric materials and structures have shown their promising potential of applications in sensor, energy harvester, actuator and so on. However, the large complexity of such materials and structures poses a significant challenge to the accurate and efficient prediction of their piezoelectric behavior which is significant for guiding and optimizing their applications. In this paper, a Direct FE 2 method was proposed for concurrent multilevel modeling of the coupled electromechanical behavior of multiscale piezoelectric materials and structures. The energy equilibrium and kinematic constraints between macro- and meso-scales were satisfied by prescribing periodic boundary conditions for both displacement and electric potential, which were derived from the governing equation of FEM. Another boundary condition was prescribed to the center node of each RVE, to prevent rigid motion and shifting of electric potential of meso-scale RVEs. All these boundary conditions can be easily prescribed to the Direct FE 2 using multiple points constraints (MPCs), a commonly used feature in most commercial software. The accuracy, computational efficiency and ease of numerical implementation of the proposed Direct FE 2 method were validated using a series of multiscale simulations, including the quasi-static response of homogeneous piezoelectric panels, an arc honeycomb structure, a regular honeycomb structure and a piezoelectric composite panel, as well as the dynamic response of the piezoelectric composite panel. It shows that the proposed Direct FE 2 method will be valuable for large-scale simulations of complicated multiscale piezoelectric materials and structures. • A Direct FE 2 method is proposed for concurrent multilevel modeling of multiscale piezoelectric materials and structures. • The proposed methods can accurately capture the coupled electromechanical response of piezoelectric materials and structures. • The computational efficiency of the proposed method is 9 times higher than traditional FE simulations. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Observing a dust aerosol layer at a height of 3–4 km above the ground on the southern margin of the Tarim Basin.
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He, Qing, Li, Jinglong, Zhao, Tianliang, Zhang, Hailiang, and Meng, Lu
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DUST , *AEROSOLS , *GLOBAL environmental change , *PARTICULATE matter , *EVAPOTRANSPIRATION , *CHEMICAL models , *CLIMATE change - Abstract
The vertical distribution and transport properties of dust aerosols play a key role in regional and even global climate and environmental changes. However, there are still gaps in understanding the optical properties, transport mechanisms, and topographic effects on dust in the dust-prone area-southern margin of the Tarim Basin. In this study, we use the Ground-Based Aerosol Lidar (GBQL-01) installed in Hotan and Minfeng in cooperation with the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) to synthesize and analyze the dust formation process at the southern margin of the basin once, and to test the reliability of the ground-based aerosol lidar. The variability characteristics of meteorological elements during this dust process will be discussed. Furthermore, the Weather Research and Forecasting Model with Chemistry (WRF-Chem) was used to reproduce this dust process. The results show that the vertical transport of dust particles reaches about 4 km and 3 km in Hotan and Minfeng, respectively, and the dust aerosol stratification intensity is obvious within 1 km height in both places, and there is a dust aerosol layer at 3 km height in both places. The high winds are blocked by the large topography of the Tianshan Mountains and the northern slopes of the Tibet Plateau, and they change to northeasterly winds, triggering dusty weather outbreaks at the southern margin of the Tarim Basin. When the dusty weather subsided, dust aerosols with concentrations of 300–400 μg m−3 were still present at an altitude of 4 km, and a clear suspended dust phenomenon was formed. Meanwhile, the increase of wind speed and relative humidity, as well as the decrease of temperature, easily contribute to the occurrence of dusty weather and the transport of particulate matter. This work provides a useful reference for the study of regional climate change, topographic effects and "suspended dust". • The evaluation of the ground-based aerosol lidar's performance was conducted in an integrated manner using CALIPSO and particulate matter data. This assessment is essential for future studies. • Data on the height of dust stratification in the southern margin of the Tarim Basin (Hotan and Minfeng) was collected, confirming the presence of a stable aerosol layer at an altitude of 3 km. • The analysis using the WRF-Chem model clearly demonstrates the influence of topographic effects on dust aerosols. Additionally, this study confirms the occurrence of a unique phenomenon known as "suspended dust.". [ABSTRACT FROM AUTHOR]
- Published
- 2024
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