1. Human chorionic gonadotropin-secreting osteosarcoma.
- Author
-
Sanchez NG, Horvai AE, Zacco E, and Monga V
- Subjects
- Humans, Female, Adult, Bone Neoplasms diagnosis, Femoral Neoplasms diagnosis, Femoral Neoplasms genetics, Femoral Neoplasms diagnostic imaging, Paraneoplastic Syndromes diagnosis, Pregnancy, Osteosarcoma diagnosis, Chorionic Gonadotropin, beta Subunit, Human blood, Chorionic Gonadotropin, beta Subunit, Human metabolism
- Abstract
Secretion of beta human chorionic gonadotropin (β-hCG) is a rare, recently recognised paraneoplastic syndrome. Herein, we present a case of a woman in her 30s with right femur conventional high-grade osteosarcoma and a positive screening urine pregnancy test. Subsequent workup failed to reveal an intrauterine or extrauterine pregnancy. Rather, pathology and gene expression studies confirmed serum β-hCG production by osteosarcoma cells. Though the prognostic implications of β-hCG expression are unclear, β-hCG may be a useful surveillance marker to monitor disease progression or recurrence., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.)
- Published
- 2025
- Full Text
- View/download PDF