1. Temporal trends in organ donation among cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation.
- Author
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Koukousaki D, Kosmopoulos M, Mallow J, Sebastian PS, Monti C, Gutierrez A, Elliott A, Kalra R, Gurevich S, Alexy T, Bruen C, Kirchner V, Bartos JA, and Yannopoulos D
- Subjects
- Humans, Male, Female, Middle Aged, Retrospective Studies, Adult, Tissue Donors statistics & numerical data, Aged, Tissue and Organ Procurement statistics & numerical data, Tissue and Organ Procurement methods, Tissue and Organ Procurement trends, Out-of-Hospital Cardiac Arrest therapy, Out-of-Hospital Cardiac Arrest mortality, Cardiopulmonary Resuscitation methods, Cardiopulmonary Resuscitation statistics & numerical data, Cardiopulmonary Resuscitation trends, Extracorporeal Membrane Oxygenation statistics & numerical data, Extracorporeal Membrane Oxygenation trends, Extracorporeal Membrane Oxygenation methods
- Abstract
Aims: This study explores the evolution of organ donation from patients treated with extracorporeal-cardiopulmonary-resuscitation (ECPR) for refractory out-of-hospital-cardiac-arrest (OHCA) and evaluates the public health benefits of a mature ECPR program., Methods: This retrospective, single-center study included OHCA patients (2016-2023) who had mostly initial shockable rhythms and were treated with ECPR. Organ donation rates from non-survivors through these years were analyzed. The public health benefit of ECPR was determined by the ratio of the sum of survivors with Cerebral Performance Category 1-2 and non-survivors who donated at least 1 solid organ, to the total ECPR patients. Temporal trends were analyzed yearly using linear regression., Results: Out of 419 ECPR patients presenting with refractory OHCA over the study period, 116 survived neurologically intact (27.7%). Among non-survivors (n = 303), families of 41 (13.5%) consented to organ donation (median age 51 years, 75.6% male) and organs from 38 patients were harvested, leading to 74 organ transplants to 73 recipients. The transplanted organs included 43 kidneys (58.1%), 27 livers (36.5%), 3 lungs (4%), and 1 heart (1.4%), averaging 2.4 ± 0.9 accepted organs/donor. The number of organ donors and successful transplants correlated positively with the years since the ECPR program's initiation (p
trend = 0.009, ptrend = 0.01). Overall, 189 patients (116 survivors, 73 organ recipients) benefited from ECPR, achieving organ-failure-free survival. The cumulative public health benefit of ECPR, considering the 116 survivors and 38 donors was 36.8%., Conclusion: The public health benefits of an established ECPR program extend beyond individual ECPR patient survival, forming a new, previously under-recognized source of transplant donors., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ‘This work was supported by a grant from the American Heart Association that was awarded to R.K. (AHA 23TPA1140962). There are no other known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.’., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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