Search

Background: Disparities persist in testing and treatment for hepatitis C virus (HCV), leaving socially marginalized populations, including people who inject drugs (PWID), less likely to benefit from curative treatment. Linkage services are often insufficient to overcome barriers to navigating the medical system and contextual factors. Methods: The You're Empowered for Treatment Initiation (YETI) Partner trial is a single-site randomized controlled trial evaluating the efficacy of a two-session behavioral intervention that engages injecting partners as peer navigators for HCV treatment. We aim to recruit 250 PWID and their primary injecting partners in San Francisco, California, randomizing them 1:1 to either a control or intervention group. The primary outcome is the initiation of HCV treatment, with secondary outcomes including treatment completion and sustained virologic response 12 weeks post-treatment. Data will be collected through questionnaires and electronic health records and analyzed using intention-to-treat and mixed-effects models. Discussion: This trial will provide evidence of a new HCV treatment linkage intervention leveraging the support of primary injecting partners to initiate HCV treatment. If successful, the intervention could inform public health strategies and policies to address HCV in marginalized populations. Trial registration: ClinicalTrials.gov NCT06179498. Registered on December 22, 2023. [ABSTRACT FROM AUTHOR]

Background: Mentorship and research experiences are crucial for STEMM career entry and advancement. However, systemic barriers have excluded people from historically underrepresented groups. Methods: In 2021, a virtual "matchmaking event" was held to connect NIH-funded research mentors with historically underrepresented trainees and initiate mentored research experiences. Survey data collected over 12 months was analyzed to evaluate the program's success considering the number of mentor-trainee connections, mentor-trainee research experience matches, and NIH diversity supplement application status. Statistical tests, including student's t-test, ANCOVAs, and chi-square tests, evaluated differences between attendee groups and survey time points. Results: Out of 314 mentors contacted and 99 registered trainees, 113 mentors and 92 trainees participated. Among mentors (n = 73), 53% identified as women, 56% as non-Hispanic white, and a majority (81%) reported being the first in their family to attend college. Among trainees (n = 79), about two-thirds (67%) identified as women, 47% identified as Hispanic/Latinx, and 15% identified as Black/African American. Both mentors and trainees were extremely satisfied with the overall event (57% and 69%, respectively) and would recommend it to others (74% and 90%, respectively). Most mentor participants established at least one mentor-trainee connection after the event (n = 64, 57%), a mentor-trainee research experience match (n = 40, 35%), and planned to submit an NIH diversity supplement (n = 31, 27%). Many trainees obtained paid positions through the mentor-trainee research experience. One year after the event, 11 trainees secured NIH diversity supplement funding with their mentors. Conclusions: The matchmaking event began bridging a much-needed gap in the research pathway by creating opportunities for trainees to connect with mentors and obtain funded research opportunities. [ABSTRACT FROM AUTHOR]