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5 results on '"Muili, Fatima"'

1. List of contributors

Author

Achur, Rajeshwar, primary, Adhikary, Krishnendu, additional, Ahire, Eknath D., additional, Akhila, A., additional, Alekhya, Kella, additional, Anousakis, Ch., additional, Ansar, Waliza, additional, Aranha, Ivan, additional, Aravind, Vulli, additional, Arora, Naina, additional, Badgaiyan, Rajendra D., additional, Bagchi, Debasis, additional, Bahekar, Triveni Nilkanth, additional, Balekundri, Amruta, additional, Banerjee, Priyanka, additional, Banerjee, Ritam, additional, Banerjee, Pradipta, additional, Banik, Samudra P., additional, Bansal, Suraj, additional, Baral, Tejaswini, additional, Barh, Debmayla, additional, Baron, David, additional, Batabyal, Nandita, additional, Benson, Ruby, additional, Bhattacharya, Subhrajit, additional, Bhattacharyya, Jhimli, additional, Biswas, Ayan, additional, Biswas, Pallabi, additional, Blanco, Tracey, additional, Blum, Kenneth, additional, Bowirrat, Abdalla, additional, Braverman, Eric R., additional, Chatterjee, Ananya, additional, Chaudhry, Anubha, additional, Chaurasia, Rameshwar Nath, additional, Chowdhury, Sumana Roy, additional, Dakshayini, P.N., additional, Damarasingu, Prasanth, additional, Darshan, J.C., additional, Das, Siddhartha, additional, Das, Arpita, additional, Dasari, Rajasekhar, additional, De, Shaoli, additional, Debnath, Anirban, additional, Dennen, Catherine, additional, Dharmamoorthy, G., additional, Dhavale, Raiu K., additional, Dhingra, Sameer, additional, Downs, B. William, additional, Ejaz, Laila, additional, Ejaz, Haris, additional, Elman, Igor, additional, Evangelou, E., additional, Favas, T.T., additional, Garg, Ravindra K., additional, Giordano, John, additional, Gogoi, Maya, additional, Gold, Mark S., additional, Gupta, Munesh Kumar, additional, Gupta, Ashim, additional, Gupta, Abhishek Amod, additional, Han, David, additional, Hanumegowda, Sujatha M., additional, Hati, Subrota, additional, Helan, K.P., additional, Hemachudha, Pasin, additional, Hemachudha, Thiravat, additional, Hossain, Ashfaque, additional, Hostert, Alyssa, additional, Iorio, E.L., additional, Jain, Pushpendra Kumar, additional, Jana, Sudipta, additional, Jawed, Junaid Jibran, additional, Johnson, Aieshel Serafin, additional, Kachave, Ramanlal N., additional, Karati, Dipanjan, additional, Keceli, T.M., additional, Keservani, Raj K., additional, Kesharwani, Rajesh K., additional, Kesharwani, Anuradha, additional, Keshri, Anand Kumar, additional, Khalsa, Jag, additional, Khona, Dolly K., additional, Kiritsakis, Apostolos, additional, Krishnamani, Madhu, additional, Kumar, Anand, additional, Kumar, Podilapu Manoj, additional, Kumar, Neeraj, additional, Kumar, Shivam, additional, Kumar, Nitesh, additional, Kumari, Reena, additional, Kurian, Shilia Jacob, additional, Lall, Neha, additional, Llanos, Luis Gomez, additional, Mahajan, Sunil K., additional, Majumder, Rajib, additional, Makwana, Mitali, additional, Malhotra, Hardeep Singh, additional, Malhotra, Kiran Preet, additional, Mandal, Supriya, additional, McLaughlin, Thomas, additional, Meenakshi, Sarasa, additional, Mehra, Parul, additional, Mendes, Odete, additional, Metkus, Jarred D., additional, Mitra, Mousumi, additional, Mitra, Sudeep, additional, Mohan, Aishvaryaa, additional, Muili, Fatima, additional, Mukherjee, Swarupananda, additional, Mukherjee, Priyanka, additional, Murti, Krishna, additional, Nandi, Dilip Kumar, additional, Narapaka, Pavan Kumar, additional, Njie Mbye, Ya Fatou, additional, Oh, Angela, additional, Ohia, Sunny E., additional, Okolie, Anthonia, additional, Opere, Catherine A., additional, Paliwal, Vimal Kumar, additional, Panda, Satyajit, additional, Parihar, Vipan Kumar, additional, Patil, Dhananjay M., additional, Patil, Sharangouda J., additional, Pattanayak, Sudeepta, additional, Prabhu, Vikas Vittal, additional, Prasad, P. Dharani, additional, Prasad, Amit, additional, Preethi, Pakala, additional, Premalatha, S.J., additional, Raina, Hansika Sanjay, additional, Ramírez, Yael Quiles, additional, Rawat, Suraj Singh, additional, Renuka Jyothi, S., additional, Robinson, Conrad, additional, Roy, Uddappanda Bopaiah, additional, Rupreo, Vibeizonuo, additional, S., Theertha, additional, S.S., Kiron, additional, Saha, Rudra P., additional, Saifeddine, Mohamad, additional, Saini, Ankit Kumar, additional, Samanta, Saptadip, additional, Sannaningaiah, Devaraja, additional, Sanyal, Saptarshi, additional, Saranya, K., additional, Sarkar, Riya, additional, Sen, Amartya, additional, Sengar, Pratishtha, additional, Shahidi, F., additional, Sharma, Swati, additional, Shelke, Akshay, additional, Sheth, Meet, additional, Shibu, Shalmy M., additional, Shivaprasad, H.N., additional, Shukla, Kuldeep, additional, Simpatico, Thomas A., additional, Singh, Abhilasha, additional, Singh, Anshul, additional, Singh, Varun Kumar, additional, Singh, Abhishek Kumar, additional, Singh, Manoj Kumar, additional, Singh, Meghna, additional, Soman, Sauparnika, additional, Sonal Sekhar, M., additional, Sonawane, Deepak D., additional, Sonawane, Vijayraj N., additional, Soni, Gaurav, additional, Sravani, T., additional, Srivastava, Nimish, additional, Srivastava, Chhitij, additional, Surana, Khemchand R., additional, Tejan, Nidhi, additional, Thanos, Panayotis K., additional, Tom, Annmaria, additional, Tsitsipas, Ch., additional, Udaya Kumar, V., additional, Uniyal, Ravi, additional, Urs, Vijeth L., additional, Veeranna, S., additional, Venkatappa, Manjula M., additional, Ward, D. Isum, additional, Wozniak, Lucyna A., additional, Yadav, Latika, additional, and Manasa, Goudicherla, additional

Published
2024
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2. Ocular neurodegenerative disorders

Author

Muili, Fatima, primary, Okolie, Anthonia, additional, Hostert, Alyssa, additional, Opere, Catherine A., additional, Njie Mbye, Ya Fatou, additional, and Ohia, Sunny E., additional

Published
2024
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3. Neuroprotective Actions of Hydrogen Sulfide-Releasing Compounds in Isolated Bovine Retinae.

Author

Bush, Leah, Robinson, Jenaye, Okolie, Anthonia, Muili, Fatima, Opere, Catherine A., Whiteman, Matthew, Ohia, Sunny E., and Njie Mbye, Ya Fatou

Subjects
AQUEOUS humor, SODIUM compounds, INTRAOCULAR pressure, ENZYME-linked immunosorbent assay, OXIDATIVE stress, RETINAL ganglion cells, TRABECULAR meshwork (Eye)
Abstract

Background: We have evidence that hydrogen sulfide (H2S)-releasing compounds can reduce intraocular pressure in normotensive and glaucomatous rabbits by increasing the aqueous humor (AH) outflow through the trabecular meshwork. Since H2S has been reported to possess neuroprotective actions, the prevention of retinal ganglion cell loss is an important strategy in the pharmacotherapy of glaucoma. Consequently, the present study aimed to investigate the neuroprotective actions of H2S-releasing compounds against hydrogen peroxide (H2O2)-induced oxidative stress in an isolated bovine retina. Materials and Methods: The isolated neural retinae were pretreated with a substrate for H2S biosynthesis called L-cysteine, with the fast H2S-releasing compound sodium hydrosulfide, and with a mitochondrial-targeting H2S-releasing compound, AP123, for thirty minutes before a 30-min oxidative insult with H2O2 (100 µM). Lipid peroxidation was assessed via an enzyme immunoassay by measuring the stable oxidative stress marker, 8-epi PGF2α (8-isoprostane), levels in the retinal tissues. To determine the role of endogenous H2S, studies were performed using the following biosynthesis enzyme inhibitors: aminooxyacetic acid (AOAA, 30 µM); a cystathione-β-synthase/cystathionine-γ-lyase (CBS/CSE) inhibitor, α–ketobutyric acid (KBA, 1 mM); and a 3-mercaptopyruvate-s-sulfurtransferase (3-MST) inhibitor, in the absence and presence of H2S-releasing compounds. Results: Exposure of the isolated retinas to H2O2 produced a time-dependent (10–40 min) and concentration-dependent (30–300 µM) increase in the 8-isoprostane levels when compared to the untreated tissues. L-cysteine (10 nM–1 µM) and NaHS (30 –100 µM) significantly (p < 0.001; n = 12) prevented H2O2-induced oxidative damage in a concentration-dependent manner. Furthermore, AP123 (100 nM–1 µM) attenuated oxidative H2O2 damage resulted in an approximated 60% reduction in 8-isoprostane levels compared to the tissues treated with H2O2 alone. While AOAA (30 µM) and KBA (1 mM) did not affect the L-cysteine evoked attenuation of H2O2-induced oxidative stress, KBA reversed the antioxidant responses caused by AP123. Conclusions: In conclusion, various forms of H2S-releasing compounds and the substrate, L-cysteine, can prevent H2O2-induced lipid peroxidation in an isolated bovine retina. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Roles of Prostaglandins and Hydrogen Sulfide in an Outflow Model of the Porcine Ocular Anterior Segment Ex Vivo.

Author

Robinson, Jenaye, Bush, Leah, Okolie, Anthonia, Muili, Fatima, Ohia, Sunny, Opere, Catherine, and Mbye, Ya Fatou Njie

Subjects
INTRAOCULAR pressure, HYDROGEN sulfide, CYCLOOXYGENASE inhibitors, PROSTAGLANDINS, CYSTATHIONINE, AQUEOUS humor, TRABECULAR meshwork (Eye)
Abstract

Background: Hydrogen sulfide (H2S)-releasing compounds can reduce intraocular pressure in normotensive rabbits by increasing aqueous humor (AH) outflow through the trabecular meshwork. In the present study, we investigated the contribution of endogenous H2S and the role of intramurally generated prostaglandins in the observed increase in AH outflow facility in an ex vivo porcine ocular anterior segment model. Material and Methods: Porcine ocular anterior segment explants were perfused with Dulbecco's Modified Eagle's Medium maintained at 37 °C and gassed with 5% CO2 and 95% air under an elevated pressure of 15 mmHg for four hours. Perfusates from the anterior segment explants were collected and immediately assayed for their H2S and prostaglandin E2 content. Results: Elevating perfusion pressure from 7.35 to 15 mm Hg significantly (p < 0.001) increased H2S concentration in the perfusate from 0.4 ± 0.1 to 67.6 ± 3.6 nM/µg protein. In the presence of an inhibitor of cystathionine ß-synthase/cystathionine γ-lyase, aminooxyacetic acid (AOAA, 30 µM), or an inhibitor of 3-mercaptopyruvate sulfurtransferase, α-ketobutyric acid (KBA, 1 mM), the effects of elevated pressure on H2S levels in the perfusate was significant (p < 0.001). Furthermore, flurbiprofen (30 µM) and indomethacin (10 µM) attenuated the elevated pressure-induced increase in H2S levels in the perfusate. Interestingly, elevating perfusion pressure had no significant effect on PGE2 concentrations in the perfusate. While the inhibition of H2S biosynthesis by AOAA or KBA did not affect PGE2 levels in perfusate, flurbiprofen (30 µM) caused a significant (p < 0.05) decrease in the concentration of PGE2 under conditions of elevated perfusion pressure. Conclusions: We conclude that the elevated perfusion pressure-induced increase in H2S concentrations depends upon the endogenous biosynthesis of H2S and intramurally produced prostaglandins in the porcine anterior segment explants. While the concentration of PGE2 in the perfusate under elevated perfusion pressure was unaffected by pretreatment with inhibitors of H2S biosynthesis, it was reduced in the presence of an inhibitor of cyclooxygenase. [ABSTRACT FROM AUTHOR]

Published
2024
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