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Your search keyword '"Nir Hacohen"' showing total 7 results
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7 results on '"Nir Hacohen"'

1. The commitment of the human cell atlas to humanity

Author

Ido Amit, Kristin Ardlie, Fabiana Arzuaga, Gordon Awandare, Gary Bader, Alexander Bernier, Piero Carninci, Stacey Donnelly, Roland Eils, Alistair R. R. Forrest, Henry T. Greely, Roderic Guigo, Nir Hacohen, Muzlifah Haniffa, Emily Sarah Kirby, Bartha Maria Knoppers, Arnold Kriegstein, Ed S. Lein, Sten Linnarsson, Partha P. Majumder, Miriam Merad, Kerstin Meyer, Musa M. Mhlanga, Garry Nolan, Ntobeko A. B. Ntusi, Dana Pe’er, Shyam Prabhakar, Maili Raven-Adams, Aviv Regev, Orit Rozenblatt-Rosen, Senjuti Saha, Andrea Saltzman, Alex K. Shalek, Jay W. Shin, Henk Stunnenberg, Sarah A. Teichmann, Timothy Tickle, Alexandra-Chloe Villani, Christine Wells, Barbara Wold, Huanming Yang, and Xiaowei Zhuang

Subjects
Science
Abstract

Abstract The Human Cell Atlas (HCA) is a global partnership “to create comprehensive reference maps of all human cells—the fundamental units of life – as a basis for both understanding human health and diagnosing, monitoring, and treating disease.” ( https://www.humancellatlas.org/ ) The atlas shall characterize cells from diverse individuals across the globe to better understand human biology. HCA proactively considers the priorities of, and benefits accrued to, contributing communities. Here, we lay out principles and action items that have been adopted to affirm HCA’s commitment to equity so that the atlas is beneficial to all of humanity.

Published
2024
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2. Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial

Author

Meghan J. Mooradian, Florian J. Fintelmann, Thomas J. LaSalle, Judit Simon, Alexander Graur, Alona Muzikansky, Mari Mino-Kenudson, Sophia Shalhout, Howard L. Kaufman, Russell W. Jenkins, Donald Lawrence, Aleigha Lawless, Tatyana Sharova, Raul N. Uppot, Jacy Fang, Emily M. Blaum, Anna L. K. Gonye, Irena Gushterova, Genevieve M. Boland, Christopher Azzoli, Nir Hacohen, Moshe Sade-Feldman, and Ryan J. Sullivan

Subjects
Science
Abstract

Abstract Image-guided percutaneous cryoablation is an established minimally invasive oncologic treatment. We hypothesized that cryoablation may modify the immune microenvironment through direct modulation of the tumor, thereby generating an anti-tumor response in tumors refractory to immune checkpoint inhibition (ICI). In this non-randomized phase II single-center study (NCT03290677), subjects with unresectable melanoma progressing on ICI underwent cryoablation of an enlarging metastasis, and ICI was continued for a minimum of two additional cycles. The primary endpoints were safety, feasibility and tumor response in non-ablated lesions. From May 2018 through July 2020, 17 patients were treated on study. The study met its primary endpoints with the combination strategy found to be safe and feasible with an objective response rate of 23.5% and disease control rate of 41% (4 partial response, 3 stable disease). Our data support further study of this synergistic therapeutic approach.

Published
2024
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3. SARS-CoV-2 infection elucidates features of pregnancy-specific immunity

Author

Dong Sun Oh, Eunha Kim, Rachelly Normand, Guangqing Lu, Lydia L. Shook, Amanda Lyall, Olyvia Jasset, Stepan Demidkin, Emily Gilbert, Joon Kim, Babatunde Akinwunmi, Jessica Tantivit, Alice Tirard, Benjamin Y. Arnold, Kamil Slowikowski, Marcia B. Goldberg, Michael R. Filbin, Nir Hacohen, Long H. Nguyen, Andrew T. Chan, Xu G. Yu, Jonathan Z. Li, Lael Yonker, Alessio Fasano, Roy H. Perlis, Ofer Pasternak, Kathryn J. Gray, Gloria B. Choi, David A. Drew, Pritha Sen, Alexandra-Chloé Villani, Andrea G. Edlow, and Jun R. Huh

Subjects
CP: Immunology, Biology (General), QH301-705.5
Abstract

Summary: Pregnancy is a risk factor for increased severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory infections, but the mechanisms underlying this risk are poorly understood. To gain insight into the role of pregnancy in modulating immune responses at baseline and upon SARS-CoV-2 infection, we collected peripheral blood mononuclear cells and plasma from 226 women, including 152 pregnant individuals and 74 non-pregnant women. We find that SARS-CoV-2 infection is associated with altered T cell responses in pregnant women, including a clonal expansion of CD4-expressing CD8+ T cells, diminished interferon responses, and profound suppression of monocyte function. We also identify shifts in cytokine and chemokine levels in the sera of pregnant individuals, including a robust increase of interleukin-27, known to drive T cell exhaustion. Our findings reveal nuanced pregnancy-associated immune responses, which may contribute to the increased susceptibility of pregnant individuals to viral respiratory infection.

Published
2024
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4. 1002 Single cell transcriptomics in kidney tissue from African American patients enrolled in the accelerating medicines partnership (AMP) implicates tubular cells in the pathogenesis of APOL1 associated lupus nephritis

Author

Richard Furie, Brad Rovin, Michelle Petri, Judith A James, Kenneth Kalunian, Maria Dall’Era, Jill Buyon, Chaim Putterman, Peter Izmirly, Betty Diamond, David Wofsy, Ming Wu, Soumya Raychaudhuri, Philip M Carlucci, Qian Xiao, Nir Hacohen, Jennifer Anolik, H Michael Belmont, Robert Clancy, Kelly Ruggles, ANNE DAVIDSON, Deepak Rao, Celine C Berthier, Andrea Fava, Diane Kamen, Joel Guthridge, Arnon Arazi, Jose Monroy-Trujillo, Kristin Haag, William Apruzzese, Fernanda Payan-Schober, Kerry Cho, Joseph Mears, Wade DeJager, Paul Hoover, Kristina Deonaraine, Siddarth Gurajala, Derek Fine, Devyn Zaminski, Jasmine Shwetar, Katie Preisinger, and Sethu Madhavan

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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5. 1012 Deep peripheral blood immunophenotyping identifies a subgroup of lupus nephritis patients characterized by high type 1 interferon signaling, persistent activated immune cells and poor renal response to standard of care at 1 year

Author

Richard Furie, Judith A James, Maria Dall’Era, Michelle A Petri, Chaim Putterman, Peter Izmirly, Jill P Buyon, Diane L Kamen, Betty Diamond, David Wofsy, Soumya Raychaudhuri, Jennifer Grossman, Fan Zhang, Jun Inamo, Nir Hacohen, Alice Horisberger, Kenneth C Kalunian, Michael B Brenner, Mariko Ishimori, David Hildeman, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Michael Weisman, Celine C Berthier, Andrea Fava, Takanori Sasaki, Jennifer L Barnas, Jennifer H Anolik, Paul J Hoover, Deepak A Rao, Joshua Keegan, James A Lederer, Joel Guthridge, Michael Belmont, Arnon Arazi, William Apruzzese, Fernanda Payan-Schober, Jeffrey Hodgin, Thomas M Eisenhaure, Steve Woodle, Maureen A McMahon, Ekaterina Murzin, Katie Preisinger, Alec Griffith, Kaitlyn Howard, Tusharkanti Ghosh, Rebecca Beuschel, John Pulford, Brandon Hancock, and Maria Gutierrez-Arcelus

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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6. 1009 In-depth analysis of myeloid cell subsets in lupus nephritis kidneys provides insights into disease mechanisms: lessons from the accelerating medicines partnership (AMP) in RA/SLE consortium

Author

Richard Furie, Joel M Guthridge, Judith A James, Maria Dall’Era, Michelle A Petri, Chaim Putterman, Jill P Buyon, Diane L Kamen, Betty Diamond, David Wofsy, Soumya Raychaudhuri, Thomas Tuschl, Jennifer Grossman, Peter M Izmirly, Qian Xiao, Nir Hacohen, Kenneth C Kalunian, Michael B Brenner, Mariko Ishimori, H Michael Belmont, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Michael Weisman, Celine C Berthier, Andrea Fava, Jennifer L Barnas, Jennifer H Anolik, Paul J Hoover, Deepak A Rao, Arnon Arazi, William Apruzzese, Fernanda Payan-Schober, Joseph Mears, Saori Sakaue, James Lederer, Michael Peters, Tony Jones, Thomas M Eisenhaure, Siddarth Gurajala, Derek Fine, David A Hildeman, Steve Woodle, Maureen A McMahon, and Jeffery Hodgin

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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7. The HLA-II immunopeptidome of SARS-CoV-2

Author

Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, and Pardis C. Sabeti

Subjects
CP: Microbiology, CP: Immunology, Biology (General), QH301-705.5
Abstract

Summary: Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides that are naturally processed and loaded onto human leukocyte antigen-II (HLA-II) complexes in infected cells. We identify over 500 unique viral peptides from canonical proteins as well as from overlapping internal open reading frames. Most HLA-II peptides colocalize with known CD4+ T cell epitopes in coronavirus disease 2019 patients, including 2 reported immunodominant regions in the SARS-CoV-2 membrane protein. Overall, our analyses show that HLA-I and HLA-II pathways target distinct viral proteins, with the structural proteins accounting for most of the HLA-II peptidome and nonstructural and noncanonical proteins accounting for the majority of the HLA-I peptidome. These findings highlight the need for a vaccine design that incorporates multiple viral elements harboring CD4+ and CD8+ T cell epitopes to maximize vaccine effectiveness.

Published
2024
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