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This paper presents an optimal active power dispatch (OAPD) problem that, unlike common economic dispatch problems, precludes unwanted mismatches on realistic power systems. The OAPD is formulated by considering the unified power flow controller (UPFC), a versatile device from the flexible AC transmission systems. However, the resultant turns into a highly nonlinear and complex optimization problem, which requires a powerful evolutionary algorithm to determine the optimal solutions. Toward this end, this paper explores the use of comprehensive learning particle swarm optimization and differential evolution as a hybrid configuration in a fuzzy framework, called hybrid fuzzy-based improved comprehensive learning particle swarm optimization-differential evolution, to address the proposed problem. To demonstrate the performance of the proposed algorithm, a set of benchmark problems, including real-world constrained optimization problems as well as a profound analysis of Schwefel problem 2.26 are provided. Moreover, to authenticate its effectiveness in solving power and energy-related problems with quite a few decision variables, four different power systems, 3-unit, 6-unit IEEE 30-bus, 10-unit, and 40-unit systems, are implemented. The IEEE 30-bus system is opted for profoundly analyzing the performance of the proposed algorithm in handling the optimal power dispatch problem considering security constraints and UPFC device, where an enhancement, at least $74,000 saving in a 365-day horizon, in total generation cost is obtained. Simulation results also validate that evolutionary algorithms need to be improved/hybridized to achieve better equilibrium between exploration and exploitation processes in a timely manner while solving power and energy-related problems. [ABSTRACT FROM AUTHOR]