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Sabia parviflora (SP, "xiao hua qing feng teng" in Chinese) was recorded as an important ethnic medicine to be used for treating viral hepatitis. The antiviral activity of four SP extracts and potent antiviral compounds evaluated with cathepsin L protease (Cat L PR) and HIV-1 protease (HIV-1 PR). UPLC-HRMS was used for identifying the bioactive components. In addition, the possible inhibitory mechanism of the identified compounds on viral protease was further discussed by molecular docking. As a result, four extracts of SP exhibited inhibitory activity of HIV-1 PR and Cat L PR with IC50 range from 0.015 to 0.80 mg/mL. Meanwhile, six compounds inhibited HIV-1 PR with IC50 range from 0.032 to 0.80 mg/mL. Moreover, procyanidin B2 had good affinity for HIV-1 PR and CatL PR protein, respectively. These findings suggest S. parviflora leaves can be used for treating HIV and procyanidin B2 may play a role in antiviral protease. [ABSTRACT FROM AUTHOR]

Studying the neural basis of human dynamic visual perception requires extensive experimental data to evaluate the large swathes of functionally diverse brain neural networks driven by perceiving visual events. Here, we introduce the BOLD Moments Dataset (BMD), a repository of whole-brain fMRI responses to over 1000 short (3 s) naturalistic video clips of visual events across ten human subjects. We use the videos’ extensive metadata to show how the brain represents word- and sentence-level descriptions of visual events and identify correlates of video memorability scores extending into the parietal cortex. Furthermore, we reveal a match in hierarchical processing between cortical regions of interest and video-computable deep neural networks, and we showcase that BMD successfully captures temporal dynamics of visual events at second resolution. With its rich metadata, BMD offers new perspectives and accelerates research on the human brain basis of visual event perception.There is a need for extensive neuroimaging datasets to facilitate the study of dynamic human visual perception. Here, the authors present a repository of whole-brain fMRI responses to over 1000 short naturalistic video clips across ten human subjects. [ABSTRACT FROM AUTHOR]

Saharan dust exerts profound impacts on the genesis and intensification of tropical cyclones (TCs). Such impacts on various stages of the TCs have yet to be explored. In this study, we utilize the Cloud‐Resolving weather research and forecasting model (WRF) to investigate the relative importance of the microphysical and radiative effects of dust on two hurricanes (Earl and Danielle) at different life stages under similar dynamical conditions in 2010. Both TCs were embedded in a dusty environment throughout their lifetime. A new dust ice nucleation scheme was implemented into the aerosol‐aware Texas A&M University two‐moment microphysical scheme in WRF. Moreover, the dust radiative effect was included in the Goddard Shortwave Scheme of WRF. Our sensitivity experiments show that the radiative effect of dust (DRAD) amplified the mid‐level ridge in the Central Atlantic Ocean through temperature perturbation, changing the tracks of Danielle and Earl. Further analyses reveal an early shift of Danielle's maximum intensity for 12 hours but a significantly suppressed Earl in DRAD. In addition, the microphysical effect of dust had little impact on the large‐scale dynamical fields and storm tracks. The inclusion of dust as ice nucleation particles results in more variations in the intensity of Danielle and Earl than in other scenarios. This is owing to the higher maximum diabatic heating rate in the rainband region that perturbs the size of the TC. This study shows the dominant dust radiative effects on both intensity and track of the storm. In addition, there is evidence that dust suppresses the early stage TC but provides favorable conditions for matured TC. Both findings have profound implications for hurricane forecast and address the importance of accounting for detailed cloud microphysics and aerosol‐TC interactions in the operational forecasting models. Plain Language Summary: This modeling study assesses how dust from the Saharan Desert affects tropical cyclones (TCs). Dust modifies the radiative transfer by reflecting and absorbing sunlight (the radiative effect) and hence the environmental temperature profile. In addition, dust also changes cloud processes (the dust microphysical effect) that perturbs the cloud distribution. A cloud‐resolving model was used to assess the dust impacts on two TCs at different development stages, that is, Danielle and Earl (2010). We found that the radiative effect of dust plays an important role in the intensity and path of both TCs. Specifically, the radiative effects of dust weakened the early stage TC Earl, resulted in an early shift of maximum intensity of the matured TC Danielle, and perturbed the path of both TCs. The dust microphysics effect, on the other hand, had little impact on the TC environment and its path but induced larger variations in the intensity of both TCs. This study reveals that dust exhibits distinct effects depending on the stage of the TC development, showing that dust suppresses the early stage TC but provides favorable conditions for the matured TC. Key Points: A dust‐related ice nucleating scheme and radiation parameterizations were implemented in the aerosol‐aware weather research and forecasting modelThe radiative effect of dust plays a larger role in the large‐scale environment and intensity of tropical cyclones (TCs) than the microphysical effectThe dust effect suppresses the early stage TC but provides favorable conditions for matured TC [ABSTRACT FROM AUTHOR]

Thirteen nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid were synthesised by introducing various amino acids and nitrogen-containing heterocyclic groups at the 30-carboxyl group, starting from 18 β -glycyrrhetinic acid. Among the 13 derivatives, 10 exhibited inhibitory activity against HIV-1 PR, with IC 50 values ranging from 0.19 to 0.94 mM. Notably, derivatives 2 , 3 and 5 displayed relatively moderate inhibitory activity, with IC 50 values below 0.24 mM. Molecular docking studies provided further insights into the interaction between derivatives ( 2 , 3 and 5 ) and the active sites of HIV-1 PR. The results revealed favourable hydrophobic-hydrophobic and hydrogen bonding interactions, with docking scores ranging from -6.22 to -7.00 and glide emodel values from -62.9 to -48.6 (kcal/mol). These findings underscore the potential of derivatives 2 , 3 and 5 as promising candidates for the development of HIV-1 PR inhibitors.