22 results on '"Park, Sophie"'
Search Results
2. Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms
- Author
-
Raskovalova, Tatiana, Jacob, Marie-Christine, and Park, Sophie
- Published
- 2024
- Full Text
- View/download PDF
3. Do Or Die. Understanding And Optimising The Learning Of Postgraduate Medical Trainees From Obstetric Emergencies – A Realist Review.
- Author
-
Stelling, Heidi, primary, Brown, Megan, primary, Bryan, Dr, primary, Park, Sophie, primary, and Vance, Gill, primary
- Published
- 2024
- Full Text
- View/download PDF
4. General practitioner workforce sustainability to maximise effective and equitable patient care: a realist review protocol
- Author
-
Park, Sophie, primary, Owen-Boukra, Emily, additional, Burford, Bryan, additional, Cohen, Tanya, additional, Duddy, Claire, additional, Dunn, Harry, additional, Fadia, Vacha, additional, Goodman, Claire, additional, Henry, Cecily, additional, Lamb, Elizabeth I, additional, Ogden, Margaret, additional, Rapley, Tim, additional, Rees, Eliot, additional, Vance, Gillian, additional, and Wong, Geoff, additional
- Published
- 2024
- Full Text
- View/download PDF
5. Generalism in Clinical Practice and Education
- Author
-
Park, Sophie and Leedham-Green, Kay
- Subjects
Generalism ,General Practice ,Person-Centred Healthcare ,Sustainable Healthcare ,Clinical Education ,Healthcare Equity and Inclusion ,Patient and Public Involvement ,Social Determinants of Health ,Healthcare Systems ,Complexity and Multi-Morbidity ,thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNH Personal and public health / health education ,thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPC General practice / Family medicine ,thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine - Abstract
Generalism is a key approach to healthcare organisation and delivery that enables person-centred, dynamic and cost-effective patient care. With its emphasis on adaptability, generalism requires expansive, nurturing and personalised approaches to clinical education in which a generalist attends to and explores patient priorities when problem-setting and co-creating management plans. Generalism in Clinical Practice and Education outlines a generalist philosophy of practice which is brought to life through interleaved examples. Written by a range of international clinicians, patients and academics, this book does not prescribe one ‘right’ way to do generalism. Rather, it seeks to inspire readers’ future engagement with generalism in practice and learning through sharing underpinning concepts, values and principles. This ‘big picture’ attention to generalism across public health, social determinants of health and clinical care is at the heart of sustainable and efficient use of resources to prioritise those in need. The book explores four key principles which in practice aim to achieve creative, inclusive and agile approaches to clinical care. The goal is to support generalism in clinical practice and education, and to produce clinical practitioners and learners that enjoy, embrace and enhance future clinical care. Praise for Generalism in Clinical Practice and Education As countries around the globe tackle meaningful reforms of their struggling health systems, a focus on the benefits of generalism in healthcare delivery is essential. This wonderful new book shares insights on how to strengthen generalism across all aspects of health care, to the benefit of individuals and communities (and health systems) everywhere.' Professor Michael Kidd, University New South Wales and University of Oxford and Past President of WONCA (World Organisation of Family Doctors). 'The clinical generalist is in danger of becoming extinct. This book explains, from both theoretical and practical perspectives, why we should not let that happen.' Professor Trisha Greenhalgh, University of Oxford 'This book extends the discourse about the importance of generalism in healthcare to a new depth and breadth. It is an extensive and scholarly application of the concept into practical action across the educational and healthcare system. Whether taking a formal academic approach to curriculum and outcomes of training, or flipping to the perspective of the community and its empowerment, this text has something new to offer. Its contents add impact to a crucial set of choices, and will help its application at many levels. Well done to all involved.' Professor Amanda Howe, University of East Anglia; Past President of the Royal College of General Practice; Past President WONCA (World Organisation of Family Doctors) 'This wonderful book is a veritable festival of generalism and education. The passion, principles and expertise of the authors radiates out from the pages. It is a perfect stimulus to enthuse and sustain a new generation of generalists, educators and scholars (ideally all three, together).' Karen Mattick, University of Exeter and President of the Association for the Study of Medical Education (ASME), as well as Deputy Editor for the Journal of Medical Education 'An authoritative and comprehensive guide to Generalism for clinicians and educators. This book will help the movement of Generalism into everyday clinical practice. The emphasis on Generalism being for all clinicians in all disciplines is well made throughout.' Professor Steve Turner, Royal Aberdeen Children’s Hospital 'This book is a celebration of generalism in medicine, a vitally important concept that the medical profession loses at its peril. The advances in specialty medicine have been spectacular over the years, but I, for one continue to be proud to call myself a general physician with a specialty interest. Most of the people we see and support have more than one condition, and benefit hugely from a generalist approach. Congratulations to Sophie Park and colleagues for reminding us'. Professor Dame Jane Dacre, General Physician and Rheumatologist and Past President of the Royal College of Physicians. 'To become a generalist doctor is to open yourself up to an endlessly fascinating and rewarding career. It's a privilege to get to know your patients whatever their problem, using medical science in the service of kindness, and understanding patients' social context. UK primary care manages 90% of NHS encounters with patients with only 9% of the funding – Generalism in Clinical Practice and Education shows that with just a little more funding, General Practice could transform the health of the nation.' Gavin Francis, GP and author
- Published
- 2024
- Full Text
- View/download PDF
6. Congratulations, You're the Oldest Person in Town! Please Accept This Cane
- Author
-
Russell, Jenna and Park, Sophie
- Subjects
Displays (Marketing) ,General interest - Abstract
Byline: Jenna Russell and Sophie Park Congratulations, You're the Oldest Person in Town! Please Accept This Cane. We're exploring how America defines itself one place at a time. In towns [...]
- Published
- 2024
7. To Town Elders, A Gift of a Cane Steeped in Lore
- Author
-
Russell, Jenna and Park, Sophie
- Subjects
Aged -- Appreciation ,Theft -- Investigations ,Staffs (Sticks, canes, etc.) -- Distribution ,Company legal issue ,Company distribution practices ,General interest ,News, opinion and commentary - Abstract
Congratulations, You're the Oldest Person in Town! Please Accept This Cane. We're exploring how America defines itself one place at a time. In towns across New England, antique canes or [...]
- Published
- 2024
8. Flow cytometric analysis of erythroid precursors and mutational signatures of lower risk myelodysplastic syndromes identify responders to erythroid stimulating agents.
- Author
-
Raddi, Marco G., Bencini, Sara, Peruzzi, Benedetta, Mattiuz, Giorgio, De Pourcq, Sven, Tanturli, Michele, Chapuis, Nicolas, Consagra, Angela, Rigodanza, Luca, Amato, Cristina, Sanna, Alessandro, Tofacchi, Elena, Attardi, Enrico, Park, Sophie, Kosmider, Olivier, Annunziato, Francesco, Fontenay, Michaela, and Santini, Valeria
- Subjects
NUCLEOTIDE sequencing ,SOMATIC mutation ,IRON overload ,IRON in the body ,ERYTHROCYTES ,PURE red cell aplasia - Abstract
This document discusses a study on the use of erythropoiesis stimulating agents (ESAs) as a treatment for anemia in low-risk myelodysplastic neoplasms (LR-MDS). The study used flow cytometry to analyze erythroid subpopulations in LR-MDS patients treated with ESAs and found that the response to ESAs was associated with an increase in certain bone marrow cells. However, this correlation was not seen in cases with a specific gene mutation. The study suggests that a combination of scoring and cell fraction analysis could predict ESA response in certain MDS cases. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
9. Impact of research activity on performance of general practices: a qualitative study.
- Author
-
Kenning, Cassandra, primary, Usher-Smith, Juliet A, additional, Jamison, James, additional, Jones, Jennifer, additional, Boaz, Annette, additional, Little, Paul, additional, Mallen, Christian, additional, Bower, Peter, additional, and Park, Sophie, additional
- Published
- 2024
- Full Text
- View/download PDF
10. The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses
- Author
-
Gibson, Jonathan, primary, Kontopantelis, Evangelos, additional, Sutton, Matthew, additional, Boaz, Annette, additional, Little, Paul, additional, Mallen, Christian, additional, McManus, Richard, additional, Park, Sophie, additional, Usher-Smith, Juliet, additional, and Bower, Peter, additional
- Published
- 2024
- Full Text
- View/download PDF
11. Integration of social determinants of health information within the primary care electronic health record: a systematic review of patient perspectives and experiences.
- Author
-
Caicedo, Nicolle Marianne Arroyave, Parry, Emma, Arslan, Nazan, and Park, Sophie
- Subjects
CLINICAL medicine ,MEDICAL information storage & retrieval systems ,SELF-evaluation ,SOCIAL determinants of health ,HUMAN services programs ,FAMILY medicine ,RESEARCH funding ,ACADEMIC medical centers ,HEALTH ,PRIMARY health care ,CINAHL database ,INFORMATION resources ,EXPERIENCE ,SYSTEMATIC reviews ,THEMATIC analysis ,MEDLINE ,ELECTRONIC health records ,CONCEPTUAL structures ,MEDICAL records ,ACQUISITION of data ,MEDICAL databases ,LITERATURE reviews ,PHYSICIAN-patient relations ,RESOURCE-limited settings ,MEDICAL screening ,PATIENTS' attitudes - Abstract
Background: Social determinants of health (SDOH) are the non-medical factors that impact health. Although geographical measures of deprivation are used, individual measures of social risk could identify those most at risk and generate more personalised care and targeted referrals to community resources. We know SDOH are important to health care, but it is not yet known whether their collection via the electronic health record (EHR) is acceptable and useful from the patient perspective. Aim: To synthesise relevant literature to explore patient perspectives on integrating information about SDOH into primary care EHRs, and the opportunities and challenges of its implementation in a general practice setting. Design & setting: Systematic review of primary care-based qualitative and mixed-method studies using thematic framework analysis. Method: Key databases were searched for articles reporting patient perspectives of SDOH collection within the primary care EHR. Qualitative and mixed-methods studies written in English were included. A framework analysis was conducted to identify themes. Results: From 14 included studies, the following five main themes were identified: rationale for SDOH screening and the anticipated outcomes; impact of the provider-patient relationship on patient perceptions; data, which included privacy concerns; screening process and referral; and recommendations for future research. Conclusion: Integration of information on SDOH into the EHR appears acceptable to patients. This review has added to the discussion of whether and how to implement SDOH screening and referral programmes into UK primary care systems. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Clinical impact of genetic alterations including germline DDX41mutations in MDS/low-blast count AML patients treated with azacitidine-based regimens
- Author
-
Sébert, Marie, Freiman, Lucie, Chaffaut, Cendrine, Guerci, Agnès, Peterlin, Pierre, Thépot, Sylvain, Beyne-Rauzy, Odile, Park, Sophie, Cluzeau, Thomas, Chermat, Fatiha, Fenaux, Pierre, Preudhomme, Claude, Clappier, Emmanuelle, Chevret, Sylvie, Adès, Lionel, Duployez, Nicolas, and Duchmann, Matthieu
- Published
- 2024
- Full Text
- View/download PDF
13. Becoming a member of a nursing community of practice: negotiating performance competence and identity.
- Author
-
Chen, Mary XiaoRong, Newman, Mark, and Park, Sophie
- Subjects
NURSING education ,UNDERGRADUATES ,NURSES' attitudes ,WORK environment ,ACQUISITION of data - Abstract
The challenge faced by newly graduated nurses from undergraduate study to practice is a persistent theme in nursing practice literatures. However, there is a lack of understanding about how this transition happens. This focused ethnographic study explored how newly graduated nurses (novices) interacted with experienced nurses and learnt in a hospital ward in Singapore. Using the 'Trajectory of identification framework' developed from Wenger's Community of Practice theory, data was collected through observation and focused group discussions. This research revealed the participating rules as the sociocultural characteristics of the nursing community, and how these characteristics are ongoingly negotiated among the nurses. The nurses' changing performative competence and identity in different situations are conceptualised as the 'Participation Space'. This study also showed how concepts of Community of Practice theory can be analytically applied and further developed in empirical study. Specifically, a conceptual 'Participation Matrix' is theorised which adds an additional tool to understand the nurses' dynamic participation and negotiation of membership in a Community of Practice. Novices' transition should be viewed as an ongoing dynamic workplace learning, through which negotiation of performative competence and identity among members take place. The soon to be novices and workplaces should be prepared with this understanding. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Access to Chronic Pain Services for Adults from Minority Ethnic Groups in the United Kingdom (UK): a Scoping Review
- Author
-
Leach, Emily, Ndosi, Mwidimi, Jones, Gareth T., Ambler, Helen, Park, Sophie, and Lewis, Jennifer S.
- Abstract
Background: Chronic pain services in the UK are required to provide services which meet the diverse needs of patients, but little is known about the access and use of these services by minority ethnic groups. Objective: To assess the available evidence regarding the ethnic profile of adults who access secondary and tertiary chronic pain services in the UK. Methods: A scoping review was conducted (August 2021–October 2021), comprising comprehensive literature searches using Embase, Medline and CINAHL databases and the grey literature. Studies were included if they reported on (i) access to chronic pain services in secondary and/or tertiary care in the UK, (ii) adults and (iii) stated the ethnicity of the involved participants. Studies were included if published between 2004 and 2021, as demographic data during this period would be broadly representative of the UK population, as per the 2021 UK census. A descriptive synthesis of the extracted data was performed. Results: The search yielded 124 records after duplicates were removed. Following title and abstract screening, 44 full texts were screened, ten of which were included in the review. Conclusions: This is the first review to explore access to chronic pain services for adults from minority ethnic groups in the UK. Given the limited number of studies that met the inclusion criteria, the review highlights the need for routine collection of ethnicity data using consistent ethnic categories within UK chronic pain services and increased involvement of minority ethnic groups within chronic pain research. Findings should inform future research that aims to improve access to UK chronic pain services for adults from minority ethnic groups.
- Published
- 2024
- Full Text
- View/download PDF
15. Faire vivre et grandir une communauté de chefs de service : Acte 2 en hématologie
- Author
-
Houot, Roch, Calmettes, Claire, Park, Sophie, Pascal, Laurent, Peffault de Latour, Regis, Pigneux, Arnaud, Quinquenel, Anne, Raffoux, Emmanuel, Thieblemont, Catherine, Touati, Mohamed, Trebouet, Adrien, Vaida, Ioana, Wémeau, Mathieu, Bastie, Jean-Noël, Bay, Jacques-Olivier, Cluzeau, Thomas, Cornillon, Jérôme, Damaj, Ghandi, Deconinck, Eric, Feugier, Pierre, Fornecker, Luc-Matthieu, Gay, Julie, Hermine, Olivier, Hospital, Marie Anne, Hunault, Mathilde, Jaccard, Arnaud, Jardin, Fabrice, Calloch, Ronan Le, Legros, Laurence, Leleu, Xavier, Lemonnier, François, Malfuson, Jean-Valere, Morel, Pierre, Ochmann, Marlene, Orsini-Piocelle, Frédérique, and Gyan, Emmanuel
- Abstract
Face à la crise de notre système hospitalier et aux défis que rencontrent les chefs de service, nous avons entrepris de créer une communauté de chefs de service d’hématologie prêts à s’entraider. Un premier séminaire a eu lieu en janvier 2023 : celui-ci a regroupé une quinzaine de chefs de service et permis de créer le premier « noyau » de la communauté. Cette communauté naissante a ensuite continué de vivre et de s’entraider tout au long de l’année 2023. En janvier 2024, nous avons élargi notre communauté à d’autres chefs de service à l’occasion d’un deuxième séminaire qui a réuni 36 participants. Au cours de cette rencontre, nous avons pris le temps de réfléchir et d’échanger ensemble sur nos missions. Nous nous sommes appuyés sur des intervenants extérieurs ainsi que sur des méthodes de co-développement et de co-construction au cours de sessions plénières, d’ateliers en petits groupes, et de temps de convivialité. Nous avons ainsi pu découvrir et expérimenter le pouvoir de l’intelligence collective, la créativité, la force, et le soutien émanant d’un tel groupe. Cette communauté de pairs, constituée de chefs de service, se révèle être un puissant outil de soutien au management. L’expérience des uns nourrit et enrichit celle des autres. Nous espérons que notre initiative inspirera des chefs de service d’autres spécialités afin qu’ensemble nous puissions mieux répondre à nos missions de chefs de service et participer à la reconstruction de l’hôpital « à partir du terrain ».
- Published
- 2024
- Full Text
- View/download PDF
16. Relationship between research activity and general practice performance: cross sectional and longitudinal analyses.
- Author
-
Gibson J, Kontopantelis E, Sutton M, Boaz A, Little P, Mallen CD, McManus R, Park S, Usher-Smith JA, and Bower P
- Abstract
Background: Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that these relationships represent a causal impact of research activity is less clear. Additionally, the bulk of the existing evidence relates to hospital settings, and it is not known if those relationships would also be found in general practice, where most patient contacts occur., Aim: We sought to (a) test whether there were significant relationships between research activity in general practice and organisational performance (b) test whether those relationships were plausibly causal., Design and Setting: We analysed national data between 2008 and 2019 using cross sectional and longitudinal analyses, on general practices in England., Methods: We used cross-sectional, panel and instrumental variable analyses to explore relationships between research activity (including measures from the NIHR Clinical Research Network and the Royal College of General Practitioners) and practice performance (including clinical quality of care, patient reported experience of care, prescribing quality and hospital admissions) Results: In cross-sectional analyses, research activity was positively associated with several measures of practice performance, including clinical quality of care, patient reported experience of care, and reduced hospital admissions. The associations were generally modest in magnitude. However, longitudinal analyses did not support a reliable causal relationship., Conclusion: Similar to findings from hospital settings, research activity in general practice is associated with practice performance. There is less evidence that research is causing those improvements, although this may reflect the limited level of research activity in most practices. We identified no negative impacts, suggesting that research activity is a potential marker of quality and something that high quality practices can deliver alongside their core responsibilities., (Copyright © 2024, The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
17. GP workforce sustainability to maximise effective and equitable patient care: a realist review of what works, for whom and in what circumstances?
- Author
-
Owen E, Burford B, Cohen T, Duddy C, Dunn H, Fadia V, Goodman C, Henry C, Lamb E, Ogden M, Rapley T, Rees E, Vance G, Wong G, and Park S
- Subjects
- Humans, United Kingdom, General Practitioners supply & distribution, General Practice organization & administration
- Abstract
Background: UK general practice has been described as being in crisis. A shortage and exodus of GPs is an urgent and challenging problem, attracting significant media attention, widespread public debate, and policy action., Aim: Our review aims to examine which aspects of the healthcare system affect GP workforce sustainability, how, why, and for whom., Method: A realist review is an interpretive, theory-driven approach to evidence synthesis, that brings together data from quantitative, qualitative, mixed methods research, and the wider grey literature (e.g., policy documentation). Using this data allows us to examine a diverse range of evidence with a clear focus on understanding factors which support (or hinder) GP workforce sustainability, how these are shaped by contexts, and the mechanisms that underpin them. We identify important individual and system-level contexts that may be amenable to change., Results: We present our emerging findings in the form of a programme theory which explores human connection with patients, colleagues, and across organisations, gaining intellectual enrichment and learning systems comprising socially-situated knowledge. Relational continuity is key across these, supporting GP workforce sustainability. Challenges include standardisation, alienation and professional loneliness, inflexible organisation, and restrictive technologies., Conclusion: Our research generates new knowledge about the interdependencies between contexts, mechanisms, and outcomes. The findings can inform strategies and interventions intended to support, facilitate, and assist the GP workforce in delivering equitable and effective patient care. We identify critical gaps in knowledge and prioritise the expectations for scope and nature of future GP work and retention strategies., (© British Journal of General Practice 2024.)
- Published
- 2024
- Full Text
- View/download PDF
18. Total triage model in general practice: a systematic review of the opportunities and challenges.
- Author
-
Rolfe S, Park S, Yurtoglu N, and Owen E
- Subjects
- Humans, Health Services Accessibility, Primary Health Care, Workload, United Kingdom, Triage, General Practice
- Abstract
Background: Total triage (TT) has the potential to achieve more equitable access to primary care, to improve the overall quality of care, and enhance health outcomes. TT has gained increasing attention from the public, policymakers, and academics., Aim: To examine relevant scientific literature regarding the implementation of TT, the reported opportunities and challenges for patients and staff, and implications for practice., Method: Medline, Embase, CINAHL, and Scopus were searched for articles and grey literature between 2013 and February 2023. Included documents described the implementation of TT during in-hours general practice and provided perspectives from patients/staff. Patients and stakeholders were involved throughout each stage of the review process. Findings were synthesised using a framework approach., Results: In total, 23 documents were included at full-text screening. Analysis highlights a range of TT approaches, sometimes conflating remote and TT systems. TT was seen to both increase and reduce workload. Consistently, patient and staff views worsened with TT use. TT can increase barriers to care access with potential to exacerbate inverse care laws across the UK. Critical knowledge gaps included patient co-production in TT systems and the role of reception teams to adapt systems to meet patients' needs., Conclusion: TT can influence patient access, safety, and equity. The approach may also generate profoundly different working styles for general practice. This review adds to current debates surrounding patient access and TT, and consequences for staff/patients. The findings can be used to aid practices when navigating the new GP contract and the implementation of new TT approaches., (© British Journal of General Practice 2024.)
- Published
- 2024
- Full Text
- View/download PDF
19. Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms (MPO-MDS-Valid): protocol for a multicentre diagnostic accuracy study.
- Author
-
Planta C, Bret C, Manzoni D, Lhoumeau AC, Mayeur Rousse C, Ticchioni M, Campos L, Eischen A, Gonnet N, Merle R, Seigneurin A, Paul F, Comte E, Allieri-Rosenthal A, Tondeur S, Regnart C, Jacob MC, Labarère J, Park S, and Raskovalova T
- Subjects
- Humans, Cross-Sectional Studies, Reproducibility of Results, France, Male, Multicenter Studies as Topic, Female, Sensitivity and Specificity, Adult, Flow Cytometry, Peroxidase blood, Peroxidase metabolism, Neutrophils metabolism, Myelodysplastic Syndromes diagnosis, Myelodysplastic Syndromes blood
- Abstract
Introduction: Many patients referred for suspicion of myelodysplastic neoplasm (MDS) are subjected to unnecessary discomfort from bone marrow aspiration, due to the low disease prevalence in this population. Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression could rule out MDS with sensitivity and negative predictive value estimates close to 100%, ultimately obviating the need for bone marrow aspiration in up to 35% of patients. However, the generalisability of these findings is uncertain due to the limited sample size, the enrolment of patients at a single study site, and the reliability issues associated with laboratory-developed tests and varying levels of operator experience. This study aims to validate the accuracy attributes of peripheral blood neutrophil myeloperoxidase expression quantified by flow cytometric analysis in an independent multicentre sample., Methods and Analysis: The MPO-MDS-Valid project is a cross-sectional diagnostic accuracy study comparing an index test to a reference standard. Consecutive adult patients referred for suspicion of MDS are being recruited at seven university hospitals and one cancer centre in France. At each site, flow cytometric analysis of peripheral blood samples is performed by operators who are blinded to the reference diagnosis. A central adjudication committee whose members are unaware of the index test results will determine the reference diagnosis of MDS, based on cytomorphological evaluation of bone marrow performed in duplicate by experienced hematopathologists. The target sample size is 400 patients and the anticipated study recruitment completion date is 31 December 2025., Ethics and Dissemination: An institutional review board (Comité de Protection des Personnes Nord-Ouest III, Caen, France) approved the protocol, prior to the start of the study. Participants are recruited using an opt-out approach. Efforts will be made to publish the primary results within 6 months after study completion., Trial Registration Number: NCT05175469., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
- Full Text
- View/download PDF
20. Integration of social determinants of health information within the primary care electronic health record: a systematic review of patient perspectives and experiences.
- Author
-
Arroyave Caicedo NM, Parry E, Arslan N, and Park S
- Abstract
Background: Social determinants of health (SDOH) are the non-medical factors that impact health. Although geographical measures of deprivation are used, individual measures of social risk could identify those most at risk and generate more personalised care and targeted referrals to community resources. We know SDOH are important to health care, but it is not yet known whether their collection via the electronic health record (EHR) is acceptable and useful from the patient perspective., Aim: To synthesise relevant literature to explore patient perspectives on integrating information about SDOH into primary care EHRs, and the opportunities and challenges of its implementation in a general practice setting., Design & Setting: Systematic review of primary care-based qualitative and mixed-method studies using thematic framework analysis., Method: Key databases were searched for articles reporting patient perspectives of SDOH collection within the primary care EHR. Qualitative and mixed-methods studies written in English were included. A framework analysis was conducted to identify themes., Results: From 14 included studies, the following five main themes were identified: rationale for SDOH screening and the anticipated outcomes; impact of the provider-patient relationship on patient perceptions; data, which included privacy concerns; screening process and referral; and recommendations for future research., Conclusion: Integration of information on SDOH into the EHR appears acceptable to patients. This review has added to the discussion of whether and how to implement SDOH screening and referral programmes into UK primary care systems., (Copyright © 2024, The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
21. Impact of research activity on performance of general practices: a qualitative study.
- Author
-
Kenning C, Usher-Smith JA, Jamison J, Jones J, Boaz A, Little P, Mallen C, Bower P, and Park S
- Abstract
Background: There is evidence that engaging in research is directly associated with better performance. If this relationship is to be strengthened, it is necessary to understand the mechanisms which might underlie that relationship., Aim: To explore the perspectives of staff and wider stakeholders about mechanisms by which research activity might impact on the performance of general practices., Design & Setting: Qualitative study using semi-structured interviews with general practice professionals and wider stakeholders in England., Method: Individual interviews with 41 purposively sampled staff in 'research ready' or 'research active' general practices and 21 other stakeholders. Interviews were independently coded by three researchers using a Framework approach., Results: Participants described potential 'direct' and 'indirect' impacts on their work. 'Direct' impacts included research changing practice work (eg, additional records searches for particular conditions), bringing in additional resources (eg, access to investigations or staff) and improving relationships with patients. 'Indirect' impacts included job satisfaction (eg, perception of practice as a centre of excellence and innovation, and the variety afforded by research activity reducing burnout) and staff recruitment (increasing the attractiveness of the practice as a place to work). Respondents identified few negative impacts., Conclusions: Staff and stakeholders identified a range of potential impacts of research activity on practice performance, with impacts on their working lives most salient. Negative impacts were not generally raised. Nevertheless, respondents generally discussed potential impacts rather than providing specific examples of those impacts. This may reflect the type of research activity conducted in general practice, often led by external collaborators., (Copyright © 2024, The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
22. Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation.
- Author
-
Rombaut D, Lefèvre C, Rached T, Bondu S, Letessier A, Mangione RM, Farhat B, Lesieur-Pasquier A, Castillo-Guzman D, Boussaid I, Friedrich C, Tourville A, De Carvalho M, Levavasseur F, Leduc M, Le Gall M, Battault S, Temple M, Houy A, Bouscary D, Willems L, Park S, Raynaud S, Cluzeau T, Clappier E, Fenaux P, Adès L, Margueron R, Wassef M, Alsafadi S, Chapuis N, Kosmider O, Solary E, Constantinou A, Stern MH, Droin N, Palancade B, Miotto B, Chédin F, and Fontenay M
- Subjects
- Humans, Splicing Factor U2AF genetics, Serine-Arginine Splicing Factors genetics, RNA Splicing Factors genetics, Mutation, Transcription Factors genetics, Phosphoproteins genetics, R-Loop Structures, Myelodysplastic Syndromes drug therapy, Myelodysplastic Syndromes genetics
- Abstract
Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood. Here we find that SF3B1-mutated MDS show reduced R-loop formation predominating in gene bodies associated with intron retention reduction, not found in U2AF1- or SRSF2-mutated MDS. Compared to erythroblasts from SRSF2- or U2AF1-mutated patients, SF3B1-mutated erythroblasts exhibit augmented DNA synthesis, accelerated replication forks, and single-stranded DNA exposure upon differentiation. Importantly, histone deacetylase inhibition using vorinostat restores R-loop formation, slows down DNA replication forks and improves SF3B1-mutated erythroblast differentiation. In conclusion, loss of R-loops with associated DNA replication stress represents a hallmark of SF3B1-mutated MDS ineffective erythropoiesis, which could be used as a therapeutic target., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.