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Background: Patellar dislocation is a common knee injury and up to 35% of those who dislocate the patella can develop recurrent patellar instability. In the setting of recurrent instability, medial patellofemoral ligament (MPFL) reconstruction is often performed to restore knee stability. There has been recent interest in patient and surgical factors that influence outcomes of MPFL reconstruction. Much of the previous work has focused on influences of anatomic measures; however, patients and injury characteristics may also impact surgical outcomes. Hypothesis: Patients who experience >2 patellar dislocations before MPFL reconstruction would demonstrate poorer patient-reported outcomes (PROs) compared with those with ≤2 previous dislocations. Study design: Cohort study; Level of evidence, 3. Methods: Records were reviewed to identify patients who underwent MPFL reconstruction at a single institution between 2008 and 2016. Patients who underwent concomitant tibial tubercle osteotomy or fixation of an osteochondral fracture were excluded. Patient demographics (age, sex, body mass index [BMI]), number of previous patellar dislocations, and patient anatomic measures (Caton-Deschamps index (CDI), tibial tubercle-trochlear groove (TT-TG) distance, and trochlear sulcus angle) were collected. PROs were assessed with Norwich Patellar Instability score, Knee injury and Osteoarthritis Outcome Score (KOOS), and Marx activity score. Outcomes of patients with >2 patellar dislocations were compared with those with ≤2 dislocations using multiple linear regression analysis. Results: Medical record review revealed 160 patients who underwent isolated MPFL reconstruction (71 with ≥2 dislocations and 89 with >2 dislocations); 95 patients (59%) completed PROs at a median follow-up of 4.6 years postoperation (range, 1.0-12.6 years). Patients with ≥2 dislocations were younger (≥2 dislocations: 20.7 ± 7.3 years, >2 dislocations: 28.5 ± 10.0 years; P <.001), although there were no other differences in demographics or radiographic anatomic measures between groups. Adjusting for age, sex, BMI, CDI, TT-TG distance, and trochlear sulcus angle, patients with >2 dislocations had 13.7 points lower KOOS-Pain (P =.003), 8.3 points lower KOOS-Activities of Daily Living (P =.025), 18.2 points lower KOOS-Sports and Recreation (P =.009), and 19.8 points lower KOOS-Knee-Related Quality of Life (P =.008) subscale scores than patients with ≤2 dislocations. No significant differences in KOOS symptoms subscale, Norwich Patellar Instability, or Marx score were noted between groups. Conclusion: Patients with >2 patellar dislocations before MPFL reconstruction exhibited poorer PROs at a median of 4.8 years postoperation compared with those who had ≤2 dislocations before surgery, when adjusting for age, sex, BMI, CDI, TT-TG distance, and trochlear sulcus angle. [ABSTRACT FROM AUTHOR]

Introduction: Anterior cruciate ligament (ACL) rupture is a debilitating condition and often requires surgery to restore joint stability. Common autografts used for reconstruction include patella tendon and hamstring tendons. The primary aim of this study was to evaluate the early to mid-term clinical outcomes of ACL reconstruction using validated patient-reported outcome measures (PROMs). The secondary aim was to compare clinical outcomes between patella tendon and hamstring tendon autografts. The tertiary aim was to compare clinical outcomes between males and females. Methods: Patients with an ACL rupture were evaluated before and after surgery using PROM scores which included Lysholm, Tegner, International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Short Form-12 Item (SF-12) and EQ-5D-5L. Results: A total of 87 patients were included in the study. All PROM scores significantly improved following surgery (p < 0.001) at a mean follow-up time of 28 months (range 12 to 88 months). The patella tendon subgroup (n = 27) had superior post-operative results as compared to the hamstring tendon subgroup (n = 60) for KOOS sport and recreation (p = 0.005), KOOS quality of life (p = 0.025), KOOS overall (p = 0.026), Tegner (p = 0.046) and IKDC (p = 0.021) scores. There was no significant difference of PROM scores between males (n = 60) and females (n = 27) (p > 0.05). Conclusions: ACL reconstruction significantly improves clinical outcomes for patients with symptomatic instability consequent to ACL rupture. Overall, patella tendon autograft resulted in better clinical outcomes as compared to hamstring tendon autograft following surgery. Gender did not influence clinical outcome following ACL reconstruction. [ABSTRACT FROM AUTHOR]

A stress-avulsion fracture of the inferior pole of the patella is rare. We report a case of a 65-year-old woman who underwent open reduction and internal fixation for a transverse fracture of the patella using cannulated screws inserted from the inferior pole of the patella. Subsequently, the patient developed an avulsion fracture of the inferior pole of the patella due to a stress riser from the prominent screw head. The avulsion fracture was treated with open repair and augmentation using a cerclage wire, and the stress riser was eliminated by burying the screw head into the bone. The outcomes were satisfactory. Preventing implant-related stress risers during internal fixation of fractures requires diligent surgical techniques., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Rajeev et al.)

Objectives: Autologous tenocyte implantation (OrthoATI™) therapy has demonstrated efficacy in treating patients with tendinopathy at various anatomical sites. This study evaluates the effect of patient age, gender, and tendon biopsy site on morphology, growth, and gene expression of autologous tendon cells used to treat chronic tendinopathy., Methods: Patients undergoing OrthoATI™ for tendinopathies between 2020 and 2022 were initially treated by biopsies taken from patella tendon (PT) or palmaris longus tendon (PL). The biopsies were sent to a Good Manufacturing Practice (GMP) cell laboratory where tendon cells were isolated, cultured, and expanded for four to six weeks. Cell morphology was assessed using phase contrast microscopy. Droplet digital PCR (ddPCR) was utilized for gene expression analysis. Dichotomous results were compared between groups using x 2 or Fisher's exact tests with no adjustment for multiple comparisons. The nonparametric Mann-Whitney U and Kruskal-Wallis tests were utilized for the sex and age (<35y, 35-44y, 45-54y, >55y) analyses, respectively. All analyses were performed using IBM SPSS v27, and a two-tailed P-value of <0.05 was considered statistically significant., Results: 149 patients were included in the analysis. The PT was biopsied in 63 patients, and PL in 86 patients. There were no observer effects for age and gender between the PT and PL groups. There was no statistical significance between the PT and PL tendons for cell morphology, average cell population doubling time (PDT) (PT 83.9 vs PL 82.7 ​h, p ​= ​0.482), cellular yield (PT 16.2 vs PL 15.2 ​× ​10 6 , p ​= ​0.099), and cell viability (PT 98.7 vs PL 99.0%, p ​= ​0.277). Additionally, ddPCR analyses showed no statistical significance found in tenogenic gene expression, including collagen type I (COL1, p ​= ​0.86), tenomodulin (TNMD, p ​= ​0.837) and scleraxis (SCX, p ​= ​0.331) between PT- and PL-derived tendon cells. An age stratification analysis found no effect on growth and gene expression. COL1 was found to be higher in males when compared to females (P ​< ​0.001), but otherwise no difference was seen in growth and gene expression in the gender analysis. No postbiopsy clinical complications were reported for either group., Conclusion: This study has shown that the growth and bioactivities of tendon cells from tendon biopsies for OrthoATI™ are not affected by tendon donor site and age., Level of Evidence: IV., Competing Interests: Declaration of competing interest MHZ & AW hold shares of Orthocell Ltd., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Patellar tendinopathy (PT) is a chronic, degenerative form of tendinitis commonly affecting young, active individuals. Numerous nonsurgical treatments exist, of which platelet-rich plasma (PRP) is a frontrunner. However, heterogeneity among various PRP preparation techniques results in a large variation in treatment efficacy. This review and meta-analysis aims to investigate the effect of PRP centrifugation factors, specifically centrifuge speed and duration, on functional outcomes in patients with PT. A systematic search of the literature was performed in April 2024 on Medline and Embase. Articles involving the use of PRP in the treatment of PT were included. The risk of bias was assessed using the Risk of Bias 2 (RoB 2; the Cochrane Collaboration, England, UK) and Risk of Bias in Non-randomised Studies of Intervention (ROBINS-I; the Cochrane Collaboration, England, UK) tools. Comparative meta-analysis between the different centrifugation speeds and the different centrifugation durations was performed on articles reporting Victorian Institute of Sports Assessment - Patellar tendon (VISA-P) and visual analogue scale (VAS) scores for PT. Seventeen studies consisting of 360 participants were included in the analysis. The mean follow-up duration was 13.2 months (95% CI: 8.81 to 17.7). The mean VAS reduction was 3.85 (95% CI: -4.63 to -3.08; P < 0.01). VISA-P scores improved by 32.03 (95% CI: 24.29 to 39.78; P < 0.01). There were no significant differences between centrifuge speeds for VAS (P = 0.17) and VISA-P (P = 0.18) and between centrifuge durations for VAS (P = 0.25) and VISA-P (P = 0.27). Centrifuge speed and duration and number of centrifuge cycles did not show any significant differences in patient outcomes. There were no significant differences observed in outcomes for the different preparations of PRP. There remains a need for further high-quality RCTs using standardized PRP preparations with long-term follow-up for the development of a consensus method of PRP preparation for the treatment of PT., Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Zhang et al.)